Hyperspectral, fluorescence, and laser mapping imaging with reduced fixed pattern noise is disclosed. A method includes actuating an emitter to emit a plurality of pulses of electromagnetic radiation and sensing reflected electromagnetic radiation resulting from the plurality of pulses of electromagnetic radiation with a pixel array of an image sensor. The method includes reducing fixed pattern noise in an exposure frame by subtracting a reference frame from the exposure frame. The method is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises one or more of: electromagnetic radiation having a wavelength from about 513 nm to about 545 nm, from about 565 nm to about 585 nm, from about 900 nm to about 1000 nm, an excitation wavelength of electromagnetic radiation that causes a reagent to fluoresce, or a laser mapping pattern.

The present disclosure is directed to a method and apparatus for performing an assay on a dry slide or other solid media using a reduced reading window. In an embodiment, method of performing at least one assay comprises obtaining an image of a fluid sample located on a dry slide, positioning a reading window to correspond to an area of the fluid sample in the image, determining an interference area within the reading window based on light intensity, reducing the reading window to eliminate the interference area from the reading window, and performing at least one assay using the reduced reading window.

The present invention relates to a filter set, to a fluorescence observation system and to a method for simultaneously observing fluorescent and non-fluorescent regions of an object. The filter set comprises an illumination filter and an observation filter. The illumination filter is configured such that it efficiently transmits visible light having short wavelengths and efficiently blocks light having a long wavelength. The observation filter is configured such that it efficiently blocks visible light having short wavelengths and efficiently transmits light having a long wavelength. The illumination filter and the observation filter are configured such that the product of the transmittance of the illumination filter T.sup.I(λ) and the transmittance of the observation filter T.sup.O(λ) are very constant over a high proportion of the visible wavelength range.

A portable, modular handheld imaging system is disclosed. The modular system comprises a first housing portion and a second housing portion. The first housing portion includes at least one excitation light source. A first filter is configured to detect and permit passage of selected optical signals responsive to illumination with the excitation light to a first image sensor. A second filter is configured to detect and permit passage of selected optical signals responsive to illumination of the target surface with white light to a second image sensor. The second housing portion is configured to releasably receive the first housing portion. The second housing portion includes a display and a processor configured to receive the detected fluorescent and white light optical signals and to output a representation of the target surface to the display based on the detected optical signals.

A resolution measurement apparatus includes a stage configured to receive a display module including an optical part. The stage includes an opening that overlaps the optical part, when viewed in a plan view, when the display module is disposed on the stage. The resolution measuring apparatus further includes a plurality of cameras disposed above the stage, a light source disposed under the stage and overlapping the opening when viewed in the plan view, and a lens disposed between the light source and the stage. The lens overlaps the opening when viewed in the plan view, and the optical part overlaps the lens, when viewed in the plan view, when the display module is disposed on the stage.

Hyperspectral, fluorescence, and laser mapping imaging with reduced fixed pattern noise is disclosed. A method includes actuating an emitter to emit a plurality of pulses of electromagnetic radiation and sensing reflected electromagnetic radiation resulting from the plurality of pulses of electromagnetic radiation with a pixel array of an image sensor. The method includes reducing fixed pattern noise in an exposure frame by subtracting a reference frame from the exposure frame. The method is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises one or more of: electromagnetic radiation having a wavelength from about 513 nm to about 545 nm, from about 565 nm to about 585 nm, from about 900 nm to about 1000 nm, an excitation wavelength of electromagnetic radiation that causes a reagent to fluoresce, or a laser mapping pattern.

A laser gas detection system includes a laser gas detector and a near-eye display device. The laser gas detection system provided in the present disclosure incorporates modern display technologies and modern communication facilities to present detection results to a user of the laser gas detection system in various intuitive and highly readable forms. The laser gas detection system is further capable of projecting the detection results to a field of view of the user through the near-eye display device.

A laser gas detection system includes a laser gas detector and a near-eye display device. The laser gas detection system provided in the present disclosure incorporates modern display technologies and modern communication facilities to present detection results to a user of the laser gas detection system in various intuitive and highly readable forms. The laser gas detection system is further capable of projecting the detection results to a field of view of the user through the near-eye display device.

Provided herein are systems, devices and methods for the rapid and accurate measurement of analyte particles binding-induced aggregation of reporter particles. In the presence of analyte particles of interest, reporter particles form aggregates which increase in mean particle size as the concentration of analyte increases. From analysis of the mean particle size, determined from sample frames, the presence and/or concentration of analyte can be determined.

A data management terminal for a laser gas detector, and a data management method thereof are provided. The data management method includes: the data management terminal establishes a connection to a communication port of the laser gas detector, and obtains target gas concentration data in a target region through the connection; the data management terminal creates a target gas concentration log according to the target gas concentration data; and the data management terminal transmits the target gas concentration log to a server.