The present disclosure provides systems and methods that allow users to quickly determine titer and remove hold steps by determining a first concentration using slope spectroscopy, depleting the fluid of the expressed protein by selective adsorption, and determining a second concentration using slope spectroscopy. Further, the systems and methods of the present disclosure allows the user to forgo the use of a bioanalyzer or HPLC.

Interferometric speckle visibility spectroscopy methods, systems, and non-transitory computer readable media for recovering sample speckle field data or a speckle field pattern from an off-axis interferogram recorded by one or more sensors over an exposure time and determining sample dynamics of a sample being analyzed from speckle statistics of the speckle field data or the speckle field pattern.

A fiber optic sensor arrangement is disclosed that includes a plurality of optical fiber based sensor elements, the sensor elements configured to modify an associated optical carrier signal in accordance with changes in a sensed quantity at a location of the sensor element and a phase modulation arrangement for phase modulating each optical carrier signal in accordance with respective uncorrelated pseudorandom binary sequence signals. The sensor arrangement also includes an interferometer module for receiving each of the phase modulated optical carrier signals, the interferometer module operable to convert a change in the phase modulated optical carrier signals to a change in optical intensity of the corresponding optical carrier signal to generate a combined modulated optical intensity signal, an optical intensity detector for measuring the combined modulated optical intensity signal and generating a time varying electrical detector signal and an analog to digital convertor to convert the time varying electrical detector signal to a time varying digitized detector signal. Also included in the sensor arrangement is a decorrelator arrangement for decorrelating the time varying digitized detector signal against the respective uncorrelated pseudorandom binary sequence corresponding to each of the optical carrier signals to recover each of the modulated optical carrier signals and a demodulator for demodulating each of the modulated optical carrier signals to recover the respective optical carrier signal to determine the changes in the sensed quantity at the location of the sensor element.

An ultrasound generation member according to an aspect of the present invention includes an ultrasound generation element configured to emit ultrasound in a direction of a target object in one specific container of a plurality of containers. An ultrasound emission device according to an aspect of the present invention includes the ultrasound generation member, and a drive power supply configured to apply voltage across the ultrasound generation element of the ultrasound generation member. An ultrasound emission device according to an aspect of the present invention includes the ultrasound generation member that includes, as the ultrasound generation element, a plurality of ultrasound generation elements, and a drive power supply configured to apply voltage across the plurality of ultrasound generation elements of the ultrasound generation member.

The present invention relates to the phantom comprises water, an oil, an emulsifier and an oil coagulating agent.

There is presented an apparatus for determining one or more time response values of an analyte or a group of analytes (96) in a liquid (99) comprising a translucent element comprising pores (6), wherein the pores (6) are dead end pores (6) extending into the translucent element from respective openings (7) in the translucent element, wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris from entering the pores (6), while allowing the analyte or the group of analytes in the liquid (99) to enter the pores (6) via diffusion, one or more light sources (10) being adapted to illuminate at least the pores (6) in the translucent element (2), and a light detector (20) being adapted to at each of multiple points in time receive light (21) emerging from the pores (6) in response to illumination (11) by the one or more light sources, wherein the light detector is further adapted to generate one or more signals based on the received light, each of the one or more signals being temporally resolved and representative of at least a part of the received light, and wherein the apparatus is further comprising a data processing device comprising a processor configured to determine one or more time response values based on the one or more signals.

There is presented an apparatus for determining one or more time response values of an analyte or a group of analytes (96) in a liquid (99) comprising a translucent element comprising pores (6), wherein the pores (6) are dead end pores (6) extending into the translucent element from respective openings (7) in the translucent element, wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris from entering the pores (6), while allowing the analyte or the group of analytes in the liquid (99) to enter the pores (6) via diffusion, one or more light sources (10) being adapted to illuminate at least the pores (6) in the translucent element (2), and a light detector (20) being adapted to at each of multiple points in time receive light (21) emerging from the pores (6) in response to illumination (I I) by the one or more light sources, wherein the light detector is further adapted to generate one or more signals based on the received light, each of the one or more signals being temporally resolved and representative of at least a part of the received light, and wherein the apparatus is further comprising a data processing device comprising a processor configured to determine one or more time response values based on the one or more signals.

This disclosure provides systems, methods, and apparatus related to infrared spectroscopy. In one aspect, a device includes a first assembly, a porous membrane, and a second assembly. The first assembly defines a fluid distributor. The porous membrane overlies the fluid distributor and forms a surface of the fluid distributor. The second assembly is disposed on the first assembly. The second assembly defines a plurality of capillary arrays surrounding a window in the second assembly that exposes the porous membrane. Capillaries of each of the capillary arrays have openings on edges of the window of the second assembly and are operable to direct moisture across a surface of the porous membrane.

An apparatus for measuring through optical means temporally resolved, optical properties, and/or phenotypes, linked to cellular homeostasis. Those temporal measurements enable the detection of cell regulation through various channels linked to homeostasis, in order to assess cell viability or early cell death through rapid diagnostic.

A sample observation device includes a light source unit configured to output a pulse train in which multiple optical pulses with different center wavelengths are arranged at predetermined time intervals as excitation light; a measurement unit configured to perform time-resolved measurement on an optical response that is transmitted from the sample and corresponds to irradiation with the optical pulses included in the pulse train while scanning the sample with the excitation light, and to acquire measurement data with respect to the optical pulses; and a processing unit configured to perform linear unmixing processing on the measurement data with respect to the optical pulses on the basis of an excitation spectrum for every target included in the sample.