A phase difference control device comprises: a splitting polarizer splitting a light incident from a light source into a measurement light and a reference light, both of which are linearly polarized; a PEM imparting a phase difference to the measurement and reference lights to correspond to the spectrometry; a PEM driver supplying a modulation voltage to the PEM; a PEM control circuit inputting the reference light as a feedback signal and outputting a modulation control quantity signal to the PEM driver; and a CPU circuit monitoring the wavelength of the light in the splitting polarizer to input a wavelength variation as a wavelength signal, wherein the CPU circuit converts the wavelength signal to a feedforward signal which is output to the PEM control circuit; and the PEM control circuit performs arithmetic processing by the feedback and feedforward signals to output the modulation control quantity signal to the PEM driver.

The present disclosure belongs to the field of application of protein, and relates to use of a protein in predicting properties of a drug. The drug comprises pesticides, human drugs and veterinary drugs, and the protein is applied in the following steps: preparing a 0.02 M phosphate buffer solution with pH value of 7.4; dissolving and diluting a protein solution with the prepared buffer solution according to a signal value to obtain a protein diluent; mixing the prepared protein diluent with the drug to be tested in a molar ratio of 1: (1-300) to obtain a mixed solution to be tested, and predicting the drug properties by using fluorescence spectrum, synchronous fluorescence, three-dimensional fluorescence, circular dichroism spectrum, UV-Vis absorption spectrum, linear spectrum or band spectrum.

The present invention relates to an analytical method that includes providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms, and providing a probe selected from the group consisting of metal salts. The sample is contacted with the probe under conditions that permit coordination of the probe to the analyte, if present in the sample; and, based on any coordination that occurs, the absolute configuration of the analyte in the sample, and/or the concentration of the analyte in the sample, and/or the enantiomeric composition of the analyte in the sample is/are determined.

The present invention relates to an analytical method that includes providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms, and providing a probe selected from the group consisting of metal salts. The sample is contacted with the probe under conditions that permit coordination of the probe to the analyte, if present in the sample; and, based on any coordination that occurs, the absolute configuration of the analyte in the sample, and/or the concentration of the analyte in the sample, and/or the enantiomeric composition of the analyte in the sample is/are determined.

According to the present invention there is provided a method for enantiomeric enrichment of a mixture of two enantiomers of a chiral compound, the method comprises the application of the mixture of two enantiomers of a chiral compound onto a surface of a support material for producing a coated support, the determination a first value of an optical activity (OA.sub.0) of the coated support, the irradiation of the coated support with a light beam having an intensity at least higher than a desorption threshold of one of the enantiomers from the coated support, wherein, if the support material is achiral, the light beam is circularly polarized and, if the support material is chiral, the light beam is unpolarized, linearly polarized or circularly polarized, and the determination of a second value of the optical activity (OA.sub.e) of the coated support after said irradiation, wherein the second value of the optical activity (OA.sub.e) differs from the first value of the optical activity (OA.sub.0).

A conformation analysis device and analysis method with which discrimination can be achieved even if there is a subtle difference in a conformational structure, a given molecule can be processed in a unified manner, and large-scale computer processing can be performed, and a conformational notation device and notation method with which even in the case where a conformation cannot be uniquely determined if a rule in accordance with the IUPAC Nomenclature is followed, the conformation can be uniquely notated, a given molecule can be processed in a unified manner, and large-scale computer processing can be performed, are provided. In one embodiment of the invention, a processing section receives an input of a chemical structural formula of a compound to be analyzed, puts a predetermined code indicating a dihedral angle to each chemical binding site based on the received chemical structural formula, extracts an encoded conformational notation of interest with respect to a structure capable of uniquely determining a conformation with one conformational notation, and stores the extracted encoded conformational notation in a storage section. Then, the processing section creates a molecular model based on the extracted encoded conformational notation, performs geometry optimization and frequency calculation for the created molecular model, determines a geometry optimized structure and a physical property value of the geometry optimized structure, extracts the encoded conformational notation from the storage section, and performs a homology analysis based on the notation.

A conformation analysis device and analysis method with which discrimination can be achieved even if there is a subtle difference in a conformational structure, a given molecule can be processed in a unified manner, and large-scale computer processing can be performed, and a conformational notation device and notation method with which even in the case where a conformation cannot be uniquely determined if a rule in accordance with the IUPAC Nomenclature is followed, the conformation can be uniquely notated, a given molecule can be processed in a unified manner, and large-scale computer processing can be performed, are provided. In one embodiment of the invention, a processing section receives an input of a chemical structural formula of a compound to be analyzed, puts a predetermined code indicating a dihedral angle to each chemical binding site based on the received chemical structural formula, extracts an encoded conformational notation of interest with respect to a structure capable of uniquely determining a conformation with one conformational notation, and stores the extracted encoded conformational notation in a storage section. Then, the processing section creates a molecular model based on the extracted encoded conformational notation, performs geometry optimization and frequency calculation for the created molecular model, determines a geometry optimized structure and a physical property value of the geometry optimized structure, extracts the encoded conformational notation from the storage section, and performs a homology analysis based on the notation.

This disclosure is applicable to the field of optical measurement technology, and provides a method and device for ultrasensitive displacement sensing based on local spin characteristics, the method comprises: using an excitation light to excite and generate a near-field optical vortex field, NF-OV in which a local spin state linearly changes with a position at a detection; coupling the local spin state of the NF-OV to a far-field by using a nanostructure, so as to obtain elliptically polarized light; and detecting the spin degree of elliptically polarized light to obtain displacement information of the position at the detection. The sensing method provided by the disclosure can obtain accurate displacement information, has high sensitivity, low cost and high practical value.

This disclosure is applicable to the field of optical measurement technology, and provides a method and device for ultrasensitive displacement sensing based on local spin characteristics, the method comprises: using an excitation light to excite and generate a near-field optical vortex field, NF-OV in which a local spin state linearly changes with a position at a detection; coupling the local spin state of the NF-OV to a far-field by using a nanostructure, so as to obtain elliptically polarized light; and detecting the spin degree of elliptically polarized light to obtain displacement information of the position at the detection. The sensing method provided by the disclosure can obtain accurate displacement information, has high sensitivity, low cost and high practical value.

A vibrational circular dichroism (VCD) spectroscopy method and apparatus that can significantly reduce the measurement time needed to acquire a differential absorption spectrum compared to known approaches. A dual-comb is generated by superimposing the outputs from two quantum cascade laser sources, thus providing a third comb interferogram with beat frequencies higher than the polarization modulation frequency. Consequently, for each of the left and right circularly polarized light, the measurement signal measures transmission through the sample across the full wavelength range of interest during each period of the polarization modulation. A complete vibrational spectrum is thus acquired in each modulation of a polarization modulator, instead of only acquiring data for a single wavelength during each modulation of the polarization, as in dispersive or tunable laser VCD, or only a single Fourier component of the spectrum, as in Fourier transform VCD.