Some embodiments of the present disclosure provide an optical sensor. The optical sensor includes a semiconductive substrate; a light sensing region on the semiconductive substrate; a waveguide region configured to guide light from a wave insert portion through a waveguide portion and to a sample holding portion; and an interconnect region below the waveguide region, and the interconnect region being disposed above the light sensing region. The waveguide portion includes a first dielectric layer comprising a first refractive index and at least one second dielectric layer comprising a second refractive index, wherein the second refractive index is smaller than the first refractive index.

Electronic test devices and methods include data transfer capabilities. In one implementation, an assay device includes wireless communication capabilities to send assay result decisions and/or values to a separate processing and display device such as a smartphone. In another implementation, light sources are modulated both for performing an assay and encoding and transmitting a result of an assay.

A chemigenetic calcium indicator and a method of measuring calcium are provided. The chemigenetic calcium indicator includes a calcium-binding protein domain attached to a ligand binding protein domain. The method of measuring calcium includes administering a chemigenetic calcium indicator to a subject and determining changes in fluorescence, the chemigenetic calcium indicator including a ligand binding protein domain having a calcium-binding protein domain and a dye-ligand conjugate attached thereto.

A chemigenetic calcium indicator and a method of measuring calcium are provided. The chemigenetic calcium indicator includes a calcium-binding protein domain attached to a ligand binding protein domain. The method of measuring calcium includes administering a chemigenetic calcium indicator to a subject and determining changes in fluorescence, the chemigenetic calcium indicator including a ligand binding protein domain having a calcium-binding protein domain and a dye-ligand conjugate attached thereto.

A gas sensing element that reflects light incoming along an optical path on a sensing face, where the light reflected by the gas sensing element changes depending on a quantity of a specific gas that is in contact with the gas sensing element, and where each of a first optical fiber and a second optical fiber bends the optical path. The gas sensing element, a light source, a photodetector, and a magnetic field applicator are disposed on a same side with respect to a virtual plane that is perpendicular to an incident plane of the incoming light to the sensing face of the gas sensing element and includes a point on the optical path where light goes out from the first optical fiber and a point on the optical path where light enters the second optical fiber.

A hydrogen sensor and preparation method therefor, and a method for implementing hydrogen detection based on the hydrogen sensor. The hydrogen sensor includes an elastomeric substrate and a hydrogen sensitive material-based nanostructure positioned on the elastomeric substrate, the surface of the elastomeric substrate close to the hydrogen sensitive material-based nanostructure has a nanoarray structure, and the hydrogen sensitive material-based nanostructure and the nanoarray structure are complementary to each other. In addition, the present disclosure provides a preparation method for the hydrogen sensor and a method for implementing hydrogen detection based on the hydrogen sensor.

A hydrogen sensor and preparation method therefor, and a method for implementing hydrogen detection based on the hydrogen sensor. The hydrogen sensor includes an elastomeric substrate and a hydrogen sensitive material-based nanostructure positioned on the elastomeric substrate, the surface of the elastomeric substrate close to the hydrogen sensitive material-based nanostructure has a nanoarray structure, and the hydrogen sensitive material-based nanostructure and the nanoarray structure are complementary to each other. In addition, the present disclosure provides a preparation method for the hydrogen sensor and a method for implementing hydrogen detection based on the hydrogen sensor.

The present invention relates to an improved abnormality determining method for an automatic analyzer and related automatic analyzer that detects abnormalities for a reaction process of a reaction solution. The method for determining the presence of absence of abnormalities in the reaction process and performs the determination by acquiring acquisition conditions for multiple items of measured data, acquiring the measured data detected by a spectral detector that match the acquisition conditions, calculating a feature quantity of the measured data, generating a determination criterion based on the feature quantity, and determining the presence or absence of abnormalities by comparing the feature quantity of the measured data subject to the determination with the determination criterion. The acquisition condition includes information relating to a number of a divisions of a measured value range and information relating to the number of items of data in each divided segment.

The present invention relates to an improved abnormality determining method for an automatic analyzer and related automatic analyzer that detects abnormalities for a reaction process of a reaction solution. The method for determining the presence of absence of abnormalities in the reaction process and performs the determination by acquiring acquisition conditions for multiple items of measured data, acquiring the measured data detected by a spectral detector that match the acquisition conditions, calculating a feature quantity of the measured data, generating a determination criterion based on the feature quantity, and determining the presence or absence of abnormalities by comparing the feature quantity of the measured data subject to the determination with the determination criterion. The acquisition condition includes information relating to a number of a divisions of a measured value range and information relating to the number of items of data in each divided segment.

This invention provides devices for use in various analytical applications including single-molecule analytical reactions. Methods for detecting analytes optically by propagating optical energy by waveguides within a substrate are provided. Analytical devices are provided which have both shallow and deep waveguides in which illumination light is transported through the deep waveguides and coupled into the shallow waveguides. The shallow waveguides provide evanescent field illumination to analytes, such as single-molecule analytes, within nanometer scale wells. Integrated devices including integrated detectors such as CMOS detectors are included.