Provided herein are methods for capturing extracellular vesicles from a biological sample for quantification and/or characterization (e.g., size and/or shape discrimination) using an SP-IRIS system. Also provided herein are methods of detecting a biomarker on captured extracellular vesicles or inside the captured vesicles (e.g., intra-vesicular or intra-exosomal biomarkers).

One embodiment of the present invention provides an apparatus for analyzing substances included in a sample. The apparatus includes a physical enclosure for holding the sample and one or more sensors positioned on an inner surface of the physical enclosure. The sensors are configured to provide information associated with the substances included in the sample. The apparatus further includes electrical conductive traces positioned on the inner surface and coupled to the one or more sensors, thereby facilitating transmission of outputs of the sensors.

The present disclosure relates to probes for analyzing a chemical composition, and related methods of analyzing a chemical composition and of manufacturing probes for analyzing a chemical composition. A benefit of the disclosed probes and methods can include luminescent chemical sensor arrays for rapid, accurate, portable and economical qualitative and quantitative analysis of a broad range of chemical compositions. A benefit of the methods disclosed herein can include the rapid, simple, and accurate analysis of trace chemicals present in chemical compositions.

The present disclosure relates to probes for analyzing a chemical composition, and related methods of analyzing a chemical composition and of manufacturing probes for analyzing a chemical composition. A benefit of the disclosed probes and methods can include luminescent chemical sensor arrays for rapid, accurate, portable and economical qualitative and quantitative analysis of a broad range of chemical compositions. A benefit of the methods disclosed herein can include the rapid, simple, and accurate analysis of trace chemicals present in chemical compositions.

Disease infection in a plant can be detected at an early stage by utilizing a boron-oxygen compound having a specific structure that selectively recognizes and forms a complex with methyl salicylate, which is a plant hormone released when a plant is infected by a pathogen, as a receptor for sensing, and by utilizing a fluorescence emission phenomenon and a change in electrochemical behavior after the reaction with methyl salicylate.

Disclosed is a method for visually identifying quality of Lilii Bulbus, including: uniformly mixing an extracting solution of a Lilii Bulbus sample to be detected with gold-silver nanoclusters, standing the mixed extracting solution for reaction, and realizing visual identification of Lilii Bulbus quality according to information of color or information of fluorescence intensity of a detection system obtained after the reaction and response difference of the color or fluorescence of Lilii Bulbus samples with different quality. Compared with that existing detection method based on chromatography and the like, the method provided by the present application has the advantages of high stability, fast response, easy operation and portable devices in addition to a broad application prospect for industrial production.

A detection device according to an aspect of the present disclosure includes a detection portion that contains a substance that emits fluorescence in a case of being irradiated with light when reacting with a plant hormone.

An optofluidic diagnostic system and methods for rapid analyte detections. The system comprises an optofluidic sensor array, a test plate and an optical detection cartridge. The sensor array supports one or more distinct sensor units, each having a reactor section designed to temporarily enter a series of different kinds of wells in the test plate. One kind of well is a sample reservoir that holds reagent solution to be transferred into the reactor section. Another kind of well is a drainage chamber that removes reagent solution from the reactor section. A third kind of well is a colorant reservoir that holds a colorant reagent transferable into a reactor section. Finally, the sensor unit is transferred to the optical detection cartridge where it is placed into an isolation booth during the optical detection process so that its flat observation face is stationed in a viewing window opposite an optical detector lens.

An optofluidic diagnostic system and methods for rapid analyte detections. The system comprises an optofluidic sensor array, a test plate and an optical detection cartridge. The sensor array supports one or more distinct sensor units, each having a reactor section designed to temporarily enter a series of different kinds of wells in the test plate. One kind of well is a sample reservoir that holds reagent solution to be transferred into the reactor section. Another kind of well is a drainage chamber that removes reagent solution from the reactor section. A third kind of well is a colorant reservoir that holds a colorant reagent transferable into a reactor section. Finally, the sensor unit is transferred to the optical detection cartridge where it is placed into an isolation booth during the optical detection process so that its flat observation face is stationed in a viewing window opposite an optical detector lens.

The instant application pertains to a process for improving or managing the recycling of monoethylene glycol from an oil and gas operation with more efficient and cost-effective monitoring. The process comprises repeatedly testing an aqueous solution comprising monoethylene glycol using a test strip to obtain results for various known parameters. The results can be calibrated versus the known parameters to determine an adjustment to the test strip result.