According to one embodiment, a determination method is provided. The determination method determines progress of a treatment of a side-product produced in a process of reacting a substance containing a halogen and silicon or reacting a substance containing silicon and a substance containing a halogen. The treatment of the side-product includes bringing the side-product into contact with a treatment fluid containing water to obtain a first solid matter. The determination method includes determining the progress of the treatment of the side-product based on a signal according to a chemical analysis of at least one of an Si-α bond (α is at least one selected from the group consisting of F, Cl, Br, and I) and an Si—H bond, of the first solid matter.

Provided herein are structure-based screening platforms and methods to identify small molecules that can bind polynucleotides and/or complexes formed by polynucleotides and proteins. Structure-based screening platforms and methods to characterize interactions of small molecules with polynucleotides and/or with complexes formed by polynucleotides and proteins are also provided herein. Methods and compositions to identify small molecules that can bind polynucleotides and/or polynucleotide-protein complexes involved in RNA splicing are also provided herein.

A quartz crystal microbalance coated with functionalized nanoparticles used to detect molecule-nanoparticle interactions to assist with characterization of difficult to predict molecule-nanoparticle interactions for novel ligand chemistries and, particularly, mixed ligand nanoparticles exhibiting different ligand morphologies, in order to quantify nanoparticle-molecule interactions independently from more complex solvation requirements.

A thermal simulation experiment method for hydrocarbon-water-rock interactions based on isotope tracing is disclosed. N-eicosane, water and feldspar grains are first heated and reacted in a high temperature high pressure (HTHP) reactor. The reactor is quenched in water to room temperature and samples from the reaction are tested to obtain the composition and content of gas products, the isotopic compositions of gas products, the water solutions and authigenic clays, the nuclear magnetic resonance (NMR) spectra of the liquid hydrocarbons and water solutions, and textures and compositions of minerals. The genetic mechanisms of mass exchange and occurrence of hydrocarbon-water-rock interactions are analyzed. A thermal simulation experiment method using multiple isotope tracing, calibrates the exchange processes and paths for H and O between the hydrocarbons, water and minerals to provide evidence for deciphering the mechanism of the organic-inorganic interactions is disclosed.

The present disclosure relates to a method for analysis of a deuterium substitution rate of a deuterium-substituted sample according to substitution positions using information of a .sup.1H-NMR spectrum of the deuterium-substituted sample.

Apparatus and methods for the detection of proteins in biological fluids such as urine using a label-free assay is described. Specific proteins are detected by their binding to highly specific capture reagents such as SOMAmers that are attached to the surface of a substrate. Changes to these capture reagents and their local environment upon protein binding modify the behavior of color centers (e.g., fluorescence, ionization state, spin state, etc.) embedded in the substrate beneath the bound capture reagents. These changes can be read out, for example, optically or electrically, for an individual color center or as an average response of many color centers.

A method of predicting the responsiveness of a patient to a pharmaceutical drug by measuring metabolites in a biological sample from the patient is disclosed. Specific drug metabolites in blood from breast cancer patients are analyzed using NMR spectroscopy whereby responsiveness of the human cancer patients before, during and after treatment with a cancer drug is assessed by measuring the change in clinical outcomes. Data obtained is used to identify particular NMR resonances that are strongly correlated with whether the patient is responsive or resistant to each drug. As such, models for predicting the responsiveness of a patient to each drug based on metabolites from the patient are provided.

This disclosure relates to the identification of interactions between ligands and in-membrane proteins using nuclear magnetic resonance spectroscopy. Also provided are methods for high-throughput identification of in-membrane ligand-membrane protein interactions.

The invention relates to detecting coagulation and coagulation-related activities including agglutination and fibrinolysis of samples. More particularly the invention relates to methods and apparatus for monitoring coagulation and/or obtaining a coagulation time of a sample using NMR-based detectors.

This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.