A method and composition of matter for detecting and decontaminating hazardous chemicals, the composition of matter including: a magnetic material for any of chemisorbing, molecularly dissociating, or decomposing a hazardous chemical, wherein the magnetic material changes its magnetic moment upon any of chemisorption, decomposition, and molecular dissociation of the hazardous chemical and the change in magnetic moment is used to detect the presence of the hazardous chemical, and wherein the hazardous chemical includes any of toxic industrial chemicals, chemical warfare agents, and chemical warfare agent related compounds.

The present invention relates to real-time impedance spectroscopy using 2d transition metal dichalcogenide material-based chemical sensor systems and methods of making and using same. Impedance approach to breakdown the resistance into multiple, measureable resistance components is used in such system. Thus, a real time impedance can be used to measure the resistance of a flake network when exposed to a gas. This change in the resistance can now be used to determine the concentration of a gas of interest, in many cases, down to a parts per trillion level. Thus, gas concentrations can efficiently and effectively determined on a more accurate level and less expensively than before.

Described is a device for testing electrical and/or electrochemical properties for a 10 cubic centimeters (cc) test cell. The device is comprised of two opposing electrodes in a test cell, wherein one or both electrodes are elongated hollow cylindrical tube(s) such that the distance between the two electrodes is adjustable and measurable. Reagents including solid in powder form, liquid, and gas are optionally introduced into the test cell through the electrode(s) that are connected to a reagent container. The test cell is a transparent insulating material such as glass, quartz, plastic, or polymer; its configuration is selected from a group consisting of an open hemicylindrical channel, a sealable cylindrical tube, or a sealable box test cell. When electrical power and/or electrical measurement equipment is attached between the electrodes, electrical and electrochemical properties are measured whilst chemical reactions are observed.

A method of assessing cytolysis of cancer cells, the method including: providing a cell substrate impedance monitoring cartridge having a plurality of chambers, each chamber having an electrode array configured for measuring cell-substrate impedance, wherein different chambers are preloaded with different target cells embodied as cancer cells of different lineage, origin or stage; adding effector cells to the plurality chambers for interaction with the target cells, wherein the effector cells are immune cells; monitoring cell-substrate impedance of the plurality of chambers before and after adding the effector cells and optionally deriving an impedance-based parameter from the impedances; and determining effectiveness of effector cell killing of the different target cells by comparing the impedances or impedance-based parameters over time.

An electrochemical detection chip includes a first substrate and a second substrate opposite to each other, a plurality of driving electrodes, first detection electrodes and second detection electrodes. The plurality of driving electrodes are arranged on a side of the first substrate facing toward the second substrate and are arranged independently. The first detection electrodes and the second detection electrodes are arranged at a plurality of positions on a side of the second substrate facing toward the first substrate that are directly opposite at least a part of the plurality of driving electrodes, and are spaced apart from each other.

Disclosed is a digital PCR chip with on-chip micro-slot array based on impedance detection and its manufacturing method. The a digital PCR chip with on-chip micro-slot array based on impedance detection includes a micro-slot array, a power management unit, a clock generation module, a digital control logic module, a driver module, an analog-to-digital converter (ADC), a backscatter module and a power-on-reset module, where the power management unit generates a standard voltage and current. The clock generation module generates clocks required for the digital module, the ADC, and an excitation for impedance test. The power-on-reset module generates a reset signal for a digital circuit, and the backscatter module completes wireless transmission of an ADC output signal to an upper computer, and the digital control logic completes sequential gating and time-division measurement of micro-slot cells.

The present disclosure is directed to a gas sensor device that detects gases with large molecules (e.g., a gas with a molecular weight between 150 g/mol and 450 g/mol), such as siloxanes. The gas sensor device includes a thin film gas sensor and a bulk film gas sensor. The thin film gas sensor and the bulk film gas sensor each include a semiconductor metal oxide (SMO) film, a heater, and a temperature sensor. The SMO film of the thin film gas sensor is an thin film (e.g., between 90 nanometers and 110 nanometers thick), and the SMO film of the bulk film gas sensor is an thick film (e.g., between 5 micrometers and 20 micrometers thick). The gas sensor device detects gases with large molecules based on a variation between resistances of the SMO thin film and the SMO thick film.

Disclosed is a digital PCR chip with on-chip micro-slot array based on impedance detection and its manufacturing method. The a digital PCR chip with on-chip micro-slot array based on impedance detection includes a micro-slot array, a power management unit, a clock generation module, a digital control logic module, a driver module, an analog-to-digital converter (ADC), a backscatter module and a power-on-reset module, where the power management unit generates a standard voltage and current. The clock generation module generates clocks required for the digital module, the ADC, and an excitation for impedance test. The power-on-reset module generates a reset signal for a digital circuit, and the backscatter module completes wireless transmission of an ADC output signal to an upper computer, and the digital control logic completes sequential gating and time-division measurement of micro-slot cells.

A blood state analysis apparatus including at least an analysis unit that uses data related to the temporal change in electrical characteristics to analyze information related to fibrinogen in a blood sample, in which the analysis unit uses at least two predetermined time points derived from the data related to the temporal change on a basis of a predetermined mathematical definition to calculate a parameter R, and acquires at least two pieces of information related to the fibrinogen in the blood sample.

Embodiments herein include a kinetic response system for measuring analyte presence on a chemical sensor element. The chemical sensor element includes one or more discrete binding detectors, each discrete binding detector including a graphene varactor. The kinetic response system includes a measurement circuit having an excitation voltage generator for generating a series of excitation cycles over a time period. Each excitation cycle includes delivering a DC bias voltage to the discrete binding detectors at multiple discrete DC bias voltages across a range of DC bias voltages. The kinetic response system includes a capacitance sensor to measure capacitance of the discrete binding detectors resulting from the excitation cycles. The kinetic response system includes a controller circuit to determine the kinetics of change in at least one of a measured capacitance value and a calculated value based on the measured capacitance over the time period. Other embodiments are also included herein.