G01N27/74

MAGNETOELASTIC MICROCARRIERS AND MONITORING SYSTEM

Certain examples of the disclosure concern an apparatus including a microcarrier configured to receive and support attachment and growth of cells, and a magnetoelastic sensor enclosed by the microcarrier. The magnetoelastic sensor is configured to vibrate in response to an activation magnetic field, and the vibration can produce a return magnetic field having detectable field characteristics associated with the attachment or growth of the cells.

Devices and methods for molecule detection based on thermal stabilities of magnetic nanoparticles

Disclosed herein are detection devices, systems, and methods that use magnetic nanoparticles (MNPs) to allow molecules to be identified. Embodiments of this disclosure include magnetic sensors (e.g., magnetoresistive sensors) that can be used to detect temperature-dependent magnetic fields (or changes in magnetic fields) emitted by MNPs, and, specifically to distinguish between the presence and absence of magnetic fields emitted, or not emitted, by MNPs at different temperatures selected to take advantage of knowledge of how the MNPs' magnetic properties change with temperature. Embodiments disclosed herein may be used for nucleic acid sequencing, such as deoxyribonucleic acid (DNA) sequencing.

Cleaning of a 3D printed article
11633788 · 2023-04-25 · ·

The present disclosure relates to a method and apparatus for cleaning a 3D printed article, in particular a 3D printed heat exchanger. After 3D printing, an article may have internal passages formed from bonded powder and said passages may contain unbonded powder that needs to be removed before further use of/processing of the article. To remove this unbonded powder, the article is filled with a cleaning fluid and vibrated. The cleaning fluid is then pumped out of the article and past a sensor that generates a magnetic field. The sensor detects the presence of powder particles in the fluid by detecting a perturbation of the magnetic field caused by said particles. The fluid is then filtered and returned to a reservoir for use. The sensor may indicate the article is sufficiently clean when a detected concentration of particles in the fluid drops below a threshold.

Cleaning of a 3D printed article
11633788 · 2023-04-25 · ·

The present disclosure relates to a method and apparatus for cleaning a 3D printed article, in particular a 3D printed heat exchanger. After 3D printing, an article may have internal passages formed from bonded powder and said passages may contain unbonded powder that needs to be removed before further use of/processing of the article. To remove this unbonded powder, the article is filled with a cleaning fluid and vibrated. The cleaning fluid is then pumped out of the article and past a sensor that generates a magnetic field. The sensor detects the presence of powder particles in the fluid by detecting a perturbation of the magnetic field caused by said particles. The fluid is then filtered and returned to a reservoir for use. The sensor may indicate the article is sufficiently clean when a detected concentration of particles in the fluid drops below a threshold.

Systems and methods for measuring magnetic fields from solvated target molecules using a magnetoresistive sensor
11633619 · 2023-04-25 · ·

A measurement system includes a container configured to contain a solvated target molecule and at least one magnetoresistive (MR) sensor device including at least one MR sensor disposed near the container and configured to measure a magnetic field generated by the solvated target molecule, each of the at least one MR sensor including a pin layer having a pinned direction of magnetization, a free layer having a direction of magnetization that varies with an applied magnetic field, and a non-conductive layer separating the pin layer and the free layer.

Systems and methods for measuring magnetic fields from solvated target molecules using a magnetoresistive sensor
11633619 · 2023-04-25 · ·

A measurement system includes a container configured to contain a solvated target molecule and at least one magnetoresistive (MR) sensor device including at least one MR sensor disposed near the container and configured to measure a magnetic field generated by the solvated target molecule, each of the at least one MR sensor including a pin layer having a pinned direction of magnetization, a free layer having a direction of magnetization that varies with an applied magnetic field, and a non-conductive layer separating the pin layer and the free layer.

MAGNETIC SIGNAL DETECTION CHIP, DETECTION CARD, NUCLEIC ACID DETECTION DEVICE, AND METHOD OF DETECTING COMPOSITION CONTAINING TARGET DNA FRAGMENT IN CHEMICAL FLUID
20230113701 · 2023-04-13 · ·

Provided is a magnetic signal detection chip. Each flow sensing component thereof includes lead portions and notch portion(s) located between the adjacent lead portions, wherein the notch portion(s) is(are) located in the flow path and at least a part of each lead portion adjacent to the notch portion is exposed to the chemical fluid, so that the flow sensing component(s) is(are) conducted when the chemical fluid completely covers the notch portion(s). Thus one could regulate the processing steps according to the sensing results of the flow sensing component, which can avoid inaccurate detection results. Further provided is a detection card including the magnetic signal detection chip and further provided is a nucleic acid detection device including the detection card. Further provided is a method of detecting composition containing target DNA fragment in chemical fluid.

MEASURING SYSTEM FOR DETERMINING GAS CONCENTRATIONS

A measurement system (100) determines gas concentrations in a gas mixture of a gas sample by utilizing thermal conductivities and paramagnetic effects of thermal conductivities in the gas mixture involving data sets (203). A circuit arrangement provides measured values with an AC signal component and with a DC signal component to a calculation and control unit (200). An oxygen concentration in the gas mixture of the gas sample is determined based on the standardized AC signal components and a concentration of another gas in the gas mixture of the gas sample is determined based on the standardized DC voltage signal components. Output signals are generated by the calculation and control unit, which indicate the determined oxygen concentration and the determined concentration of another gas in the gas mixture of the gas sample.

MEASURING SYSTEM FOR DETERMINING GAS CONCENTRATIONS

A measurement system (100) determines gas concentrations in a gas mixture of a gas sample by utilizing thermal conductivities and paramagnetic effects of thermal conductivities in the gas mixture involving data sets (203). A circuit arrangement provides measured values with an AC signal component and with a DC signal component to a calculation and control unit (200). An oxygen concentration in the gas mixture of the gas sample is determined based on the standardized AC signal components and a concentration of another gas in the gas mixture of the gas sample is determined based on the standardized DC voltage signal components. Output signals are generated by the calculation and control unit, which indicate the determined oxygen concentration and the determined concentration of another gas in the gas mixture of the gas sample.

METHODS AND APPARATUS FOR MAGNETIC MULTI-BEAD ASSAYS
20230071162 · 2023-03-09 ·

The present application discloses methods and apparatus for detecting a complex including an analyte that include contacting a sample in a solution with a population of functionalized beads of a first type, which are magnetic functionalized beads and are functionalized to include a first moiety that associates with an analyte under suitable conditions, contacting the sample solution with a population of functionalized beads of a second type, which are functionalized to include a second moiety that associates with the analyte under suitable conditions, contact resulting in formation of a complex including one of the first type of functionalized bead, the analyte, and one of the second type of functionalized bead, and detecting the complex including the analyte by detecting magnetic fields produced by the magnetic functionalized bead and by detecting the functionalized bead of the second type associated with the analyte in the complex.