An acoustic sensor detects binding of a nucleic acid analyte in an impure liquid sample by measurement of the energy of the acoustic wave resulting from the binding of the nucleic acid target to the sensor surface. The analysis may be preceded by carrying out a nucleic acid amplification procedure in situ on a crude or impure biological sample and the analysis is tolerant of the presence of reagents or by-products of the amplification procedure, and also materials present from the initial biological sample.

An acoustic sensor detects binding of a nucleic acid analyte in an impure liquid sample by measurement of the energy of the acoustic wave resulting from the binding of the nucleic acid target to the sensor surface. The analysis may be preceded by carrying out a nucleic acid amplification procedure in situ on a crude or impure biological sample and the analysis is tolerant of the presence of reagents or by-products of the amplification procedure, and also materials present from the initial biological sample.

A system for measuring a rising velocity and a deformation of a bubble in a viscous fluid includes a sample cell configured to hold a viscous fluid, a variable-diameter syringe provided at a bottom of the sample cell and configured to generate a bubble in the viscous fluid, two ultrasonic transmitting and receiving transducers arranged at different heights of the sample cell and configured to transmit first ultrasonic signals to the viscous fluid and receive second ultrasonic signals reflected by the bubble, and a host computer configured to analyze time-domain information of the second ultrasonic signals received by the two ultrasonic transmitting and receiving transducers, calculate the rising velocity of the bubble, build a mathematical model about a bubble size and a reflected sound pressure, analyze frequency-domain information of the second ultrasonic signals received by the two ultrasonic transmitting and receiving transducers, and calculate the deformation of the bubble.

A method and system for cement evaluation. The method may include disposing an acoustic logging tool into a pipe string that is disposed in a first casing of a wellbore, transmitting an acoustic wave at a first location within the wellbore from an acoustic source disposed on the acoustic logging tool, and recording one or more acoustic signals with one or more receivers on the acoustic logging tool at the first location. The method may further include performing a multichannel multimode dispersion analysis of the one or more acoustic signals, extracting one or more fluid modes propagating in the first casing from the dispersion analysis, extracting one or more pseudo-lamb waves propagating in the first casing from the dispersion analysis, extracting one or more pseudo-SH-plate waves propagating in the first casing from the dispersion analysis, and identifying a bonding condition between the first casing and a cement.

A sample testing cartridge is usable to perform a variety of tests on a visco-elastic sample, such hemostasis testing on a whole blood or blood component sample. The cartridge includes a sample processing portion that is in fluid communication with a sample retention structure. A suspension, such as a beam, arm, cantilever or similar structure supports or suspends the sample retention portion relative to the sample processing portion in a unitary structure. In this manner, the sample retention portion may be placed into dynamic excitation responsive to excitation of the cartridge and correspondingly dynamic, resonant excitation of the sample contained within the sample retention portion, while the sample processing portion remains fixed. Observation of the excited sample yields data indicative of hemostasis. The data may correspond to hemostasis parameters such as time to initial clot formation, rate of clot formation, maximum clot strength and degree of clot lysis.

A sample testing cartridge is usable to perform a variety of tests on a visco-elastic sample, such hemostasis testing on a whole blood or blood component sample. The cartridge includes a sample processing portion that is in fluid communication with a sample retention structure. A suspension, such as a beam, arm, cantilever or similar structure supports or suspends the sample retention portion relative to the sample processing portion in a unitary structure. In this manner, the sample retention portion may be placed into dynamic excitation responsive to excitation of the cartridge and correspondingly dynamic, resonant excitation of the sample contained within the sample retention portion, while the sample processing portion remains fixed. Observation of the excited sample yields data indicative of hemostasis. The data may correspond to hemostasis parameters such as time to initial clot formation, rate of clot formation, maximum clot strength and degree of clot lysis.

A method of detecting at least a blockage status in a porous member separating a measurement chamber of a device including a gas sensor positioned within the measurement chamber which is responsive to an analyte in an ambient environment to be sampled, includes emitting pressure waves from a pressure wave source which travel within the measurement chamber, measuring a first response via a first sensor responsive to pressure waves positioned at a first position within the measurement chamber, measuring a second response via a second sensor at a second position, different from the first position, and in fluid connection with the pressure wave source, determining the blockage status of the porous member based upon a functional relation of the first response and the second response.

The method comprises the following steps: a) Providing a sonotrode (1) formed from an essentially inert material with respect to the liquid metal, such as a ceramic, and preferably a silicon nitride or a silicon oxynitride, such as SIALON, or a metal essentially inert to said liquid metal, b) Immersing at least partially the sonotrode (1) in a bath of said metal, c) Applying to the sonotrode (1) power ultrasounds, particularly ultrasounds having a power greater than 10 watts to obtain the wetting of said sonotrode by said metal, d) Applying continuously to the sonotrode (1) measurement ultrasounds, also known as testing ultrasounds, particularly ultrasounds wherein the frequency is between 1 and 25 MHz, e) Applying intermittently to the sonotrode (1) power ultrasounds, particularly ultrasounds having a power greater than 10 watts, to maintain said wetting.

The method comprising the following steps: a) Providing a first bath of a liquid metal (1) comprising aluminium with a content X and magnesium with a content Y, the magnesium content Y being different to zero, b) Immersing at least partially a sonotrode (3) formed from a material inert to liquid aluminium, in the first bath of liquid metal (1), and c) Applying power ultrasounds to the sonotrode (3) so as to excite the liquid metal (1) until wetting (5) of the sonotrode (3) by the liquid metal (1) is obtained. d) Cooling the first liquid metal (1) of the first bath until solidification of the first liquid metal (1) around the sonotrode (3) is obtained, generating an intimate bond (6) between the sonotrode (3) and the solidified first liquid metal (1) having a bonding strength substantially equal to that of brazing between two metals. e) Machining the solidified first metal (1) in the form of a flange (7) configured for the attachment of a mechanical amplifier and/or of a transducer (4).

A system for semiconductor manufacturing that uses ultrasonic waves for estimating and monitoring a remaining service lifetime of a consumable element is provided. A consumable element comprises a front side arranged inside a process chamber and a back side, opposite the front side, arranged outside the process chamber. An ultrasonic transducer is arranged on the back side of the consumable element, and directed towards the front side of the consumable element. A monitoring unit is configured to estimate and monitor a remaining service lifetime of the consumable element using the ultrasonic transducer. A method for estimating and monitoring the remaining service lifetime of the consumable element using ultrasonic waves is also provided.