In this invention, chromatography is integrated on a centrifugal platform to enable low-cost automated purification. Differing from the traditional chromatography method, purification and separation of a centrifugal compound collecting platform disclosed in the present invention mainly uses a centrifugal force to drive the fluid to flow outward in the radial direction when the motor rotates. The compounds to be separated react with the column packing during the flow, and the compounds with different polarities in the sample are gradually separated. The flow of the fluid can be governed by the motor and the geometry of the fluidic design such that compounds with different characteristics can be separated and collected in different collecting chambers.

A mini point of care gas chromatographic test strip and method to measure analytes is disclosed. A system for determining the concentration of at least one analyte in a fluid sample having a plurality of analytes includes a base substrate, a first electrode pair disposed over the base substrate, and a first sensing chemistry responsive to at least one analyte in the sample. The first sensing chemistry is in electrical communication with the first electrode pair, and a first chromatographic layer is disposed over the at least one sensing chemistry. At least one analyte of the plurality of analytes moves through the first chromatographic layer at a different rate relative to the movement of other analytes of the plurality of analytes.

A mini point of care gas chromatographic test strip and method to measure analytes is disclosed. A system for determining the concentration of at least one analyte in a fluid sample having a plurality of analytes includes a base substrate, a first electrode pair disposed over the base substrate, and a first sensing chemistry responsive to at least one analyte in the sample. The first sensing chemistry is in electrical communication with the first electrode pair, and a first chromatographic layer is disposed over the at least one sensing chemistry. At least one analyte of the plurality of analytes moves through the first chromatographic layer at a different rate relative to the movement of other analytes of the plurality of analytes.

Development chambers suitable for use in thin layer chromatography are disclosed. Methods of making and using development chambers in thin layer chromatography are also disclosed.

Development chambers suitable for use in thin layer chromatography are disclosed. Methods of making and using development chambers in thin layer chromatography are also disclosed.

A microfluidic diagnostic device comprises a base and at least one switch coupled to a portion of the base, the switch comprising a flap that is pivotable with respect to the base from a first position spaced away from the base a first distance to a second position where the flap is spaced away from the base a second distance. Both the base and the switch comprise one or more channels that permit passive transportation of an aqueous solution. The switch may be formed by bending or deforming a strip to cause the flap to be in the first position when there is less than a predetermined amount of fluid within the channel of switch. When a predetermined amount of fluid is in the channel of the switch, the flap pivots to the second position, which may be achieved through power from gravity, capillarity, and/or inherent elastic energy.

A microfluidic diagnostic device comprises a base and at least one switch coupled to a portion of the base, the switch comprising a flap that is pivotable with respect to the base from a first position spaced away from the base a first distance to a second position where the flap is spaced away from the base a second distance. Both the base and the switch comprise one or more channels that permit passive transportation of an aqueous solution. The switch may be formed by bending or deforming a strip to cause the flap to be in the first position when there is less than a predetermined amount of fluid within the channel of switch. When a predetermined amount of fluid is in the channel of the switch, the flap pivots to the second position, which may be achieved through power from gravity, capillarity, and/or inherent elastic energy.

A test device includes a housing and a lid. The housing encloses an internal space, has a hole supporting a container accommodating liquid, and includes a perforation/incision part. The lid covers a hole-formed part of the housing. The housing and/or the lid includes a guide that guides the housing and the lid, so that the lid can migrate from the first position to the second position while covering the hole-formed part of the housing. In the first position, the lid covers the hole-formed part of the housing and the container and the container is not incised. During the migration of the lid from the first position to the second position, the container is pushed toward the perforation/incision part by the lid, and the container is incised to leak liquid into the internal space.

A test device includes a housing and a lid. The housing encloses an internal space, has a hole supporting a container accommodating liquid, and includes a perforation/incision part. The lid covers a hole-formed part of the housing. The housing and/or the lid includes a guide that guides the housing and the lid, so that the lid can migrate from the first position to the second position while covering the hole-formed part of the housing. In the first position, the lid covers the hole-formed part of the housing and the container and the container is not incised. During the migration of the lid from the first position to the second position, the container is pushed toward the perforation/incision part by the lid, and the container is incised to leak liquid into the internal space.

A mini point of care gas chromatographic test strip and method to measure analytes is disclosed. A system for determining the concentration of at least one analyte in a fluid sample having a plurality of analytes includes a base substrate, a first electrode pair disposed over the base substrate, and a first sensing chemistry responsive to at least one analyte in the sample. The first sensing chemistry is in electrical communication with the first electrode pair, and a first chromatographic layer is disposed over the at least one sensing chemistry. At least one analyte of the plurality of analytes moves through the first chromatographic layer at a different rate relative to the movement of other analytes of the plurality of analytes.