A Raman detecting chip for thin layer chromatography and a method for separating and detecting an analyte are provided. The Raman detecting chip for thin layer chromatography includes a silicon substrate. The silicon substrate includes a first portion, a second portion and a plurality of silicon nanowires disposed on the first portion, wherein each silicon nanowire has a top surface and a sidewall. A metal layer covers the top surface and at least a part of the sidewall of the silicon nanowire, wherein the silicon nanowire has a length L from 5 m to 15 m. The ratio between the length L1 of the side wall covered by the metal layer and the length L of the silicon nanowire is from 0.2 to 0.8.

A Raman detecting chip for thin layer chromatography and a method for separating and detecting an analyte are provided. The Raman detecting chip for thin layer chromatography includes a silicon substrate. The silicon substrate includes a first portion, a second portion and a plurality of silicon nanowires disposed on the first portion, wherein each silicon nanowire has a top surface and a sidewall. A metal layer covers the top surface and at least a part of the sidewall of the silicon nanowire, wherein the silicon nanowire has a length L from 5 m to 15 m. The ratio between the length L1 of the side wall covered by the metal layer and the length L of the silicon nanowire is from 0.2 to 0.8.

A microfluidic diagnostic device comprises a base and at least one switch coupled to a portion of the base, the switch comprising a flap that is pivotable with respect to the base from a first position spaced away from the base a first distance to a second position where the flap is spaced away from the base a second distance. Both the base and the switch comprise one or more channels that permit passive transportation of an aqueous solution. The switch may be formed by bending or deforming a strip to cause the flap to be in the first position when there is less than a predetermined amount of fluid within the channel of switch. When a predetermined amount of fluid is in the channel of the switch, the flap pivots to the second position, which may be achieved through power from gravity, capillarity, and/or inherent elastic energy.

A microfluidic diagnostic device comprises a base and at least one switch coupled to a portion of the base, the switch comprising a flap that is pivotable with respect to the base from a first position spaced away from the base a first distance to a second position where the flap is spaced away from the base a second distance. Both the base and the switch comprise one or more channels that permit passive transportation of an aqueous solution. The switch may be formed by bending or deforming a strip to cause the flap to be in the first position when there is less than a predetermined amount of fluid within the channel of switch. When a predetermined amount of fluid is in the channel of the switch, the flap pivots to the second position, which may be achieved through power from gravity, capillarity, and/or inherent elastic energy.

A microdevice for detecting aldehydes or ketones by utilizing a rotary platform, the microdevice comprising a disc-shaped rotary platform and a microfluidic structure disposed on the rotary platform, and the microfluidic structure comprising a sample storage part, an eluent storage part, a separation part, a first microfluid flow channel, a second microfluid flow channel, and an absorption pad.

A microdevice for detecting aldehydes or ketones by utilizing a rotary platform, the microdevice comprising a disc-shaped rotary platform and a microfluidic structure disposed on the rotary platform, and the microfluidic structure comprising a sample storage part, an eluent storage part, a separation part, a first microfluid flow channel, a second microfluid flow channel, and an absorption pad.

Thin layer chromatography (TEC) devices for the analysis of pico-scale samples, methods for using the devices, and methods for fabricating the devices.

A procedure for hydrogenation of alpha dimethyl styrene dimer that is scalable, economical, and safe is provided. These processes routinely provide greater than a 98% yield and require no purification step. The methods of producing hydrogenated alpha dimethyl styrene dimer comprising adding to a reactor under nitrogen a catalyst comprising Ru/C or Rh/C and an alpha dimethyl styrene dimer to form a catalyst and alpha dimethyl styrene dimer reaction mixture. The reaction mixture is then heated under pressure until hydrogenation of the alpha dimethyl styrene dimer is complete. To recover the hydrogenated alpha dimethyl styrene dimer, the reaction mixture is filtered through a celite bed under nitrogen.

A procedure for hydrogenation of alpha dimethyl styrene dimer that is scalable, economical, and safe is provided. These processes routinely provide greater than a 98% yield and require no purification step. The methods of producing hydrogenated alpha dimethyl styrene dimer comprising adding to a reactor under nitrogen a catalyst comprising Ru/C or Rh/C and an alpha dimethyl styrene dimer to form a catalyst and alpha dimethyl styrene dimer reaction mixture. The reaction mixture is then heated under pressure until hydrogenation of the alpha dimethyl styrene dimer is complete. To recover the hydrogenated alpha dimethyl styrene dimer, the reaction mixture is filtered through a celite bed under nitrogen.

A test device includes a housing and a lid. The housing encloses an internal space, has a hole supporting a container accommodating liquid, and includes a perforation/incision part. The lid covers a hole-formed part of the housing. The housing and/or the lid includes a guide that guides the housing and the lid, so that the lid can migrate from the first position to the second position while covering the hole-formed part of the housing. In the first position, the lid covers the hole-formed part of the housing and the container and the container is not incised. During the migration of the lid from the first position to the second position, the container is pushed toward the perforation/incision part by the lid, and the container is incised to leak liquid into the internal space.