A composition and an assay solution for the determination of dissolved borate concentration comprising a catechol dye, a solubilizing agent, and a buffer are described. The composition and assay solution may further comprise a solubilizing agent. The catechol dye acts as a chemical borate sensor. The chemical borate sensor changes its optical properties upon binding to borate. The multivalent cation chelator binds multivalent cations present in a sample being analyzed. The buffer prevents changes in pH. The solubilizing agent aids in solubilizing the catechol dye, multivalent cation chelator, and/or the buffer.

The subject innovation relates to a device for determining the concentration of a base and here especially hydrogen carbonate, whereby the device contains at least one pH indicator, at least one solid acid, and a mixture of at least one anionic surfactant and one nonionic surfactant. In addition, the subject innovation relates to a method for measuring the base concentration using the device according the subject innovation and a method for increasing the sensitivity of a testing device.

Described herein are pH responsive compounds, micelles, and compositions useful for the detection of primary and metastatic tumor tissues. Compounds described herein are imaging agents useful for the detection of primary and metastatic tumor tissue (including lymph nodes). Real-time fluorescence imaging during surgery aids surgeon in the detection of metastatic lymph nodes or delineate tumor tissue versus normal tissue, with the goal of achieving negative margins and complete tumor resection.

The present disclosure is drawn to compositions and methods for loop-mediated isothermal amplification (LAMP) analysis utilizing a pH-dependent output signal. The composition can comprise a pH sensitive dye, and a plurality of non-interfering LAMP reagents. The method can comprise providing an assembly of a solid phase medium and a composition, depositing a biological sample onto the solid phase medium, and heating the assembly to an isothermal temperature sufficient to facilitate a LAMP reaction.

Disclosed herein are devices, wound dressings and methods for determining the pH of fluid or a wound exudate at a wound. Example devices include a device comprising a surface configured to contact the fluid or wound and a pH indicator covalently bound thereto or applied to the surface, wherein the pH indicator has a first colour prior to contact with the fluid or the wound exudate and changes colour as a function of the pH of the fluid or wound exudate. Example devices include a device which indicates wound exudate loading within a wound dressing and wound dressing comprising an absorbent layer and a moisture indicator which indicates would exudate loading within the dressing, wherein the visibility of the moisture indictor changes as a result of a physical transformation of a first material within the dressing. Systems, devices, and methods are provided for monitoring wound status and progression by measuring pH levels indicated by pH-sensitive wound dressings. In some implementations, a wound is monitored by capturing an image of the pH-sensitive wound dressing and processing the captured image to determine the color of a pH indicator included on the wound dressing. The color of the indicator is determined in terms of RGB values from the image, and a pH value for the wound dressing is calculated from the dressing RGB values. The calculated pH value is then relayed to a user to be used as an indicator of wound status or health.

Disclosed herein are immediate release oral dosage forms that comprising esketamine and one or more excipients that produce a visual indication of the presence of the dosage form within a vessel containing a liquid beverage. The visual indication can assist in thwarting an attempt to use the esketamine to render another individual more susceptible to criminal exploitation.

Embodiments of the present invention relate to microfluidic devices and systems comprising such devices for use in the determination of sample characteristics. Certain embodiments relate to methods for determining one or more characteristics of a sample comprising a compound for in vivo use. Aptly, certain embodiments of the present invention relate to devices and methods for assessing radiopharmaceuticals and their suitability for administration to a patient in need thereof.

A sensor comprising a randomly functionalised polyolefin having functional groups, a sensing compound and optionally a polar solvent, wherein the polyolefin has a crystallinity between 0 and 35%, as determined with DSC, and wherein the amount of monomeric moieties comprising functional groups is at least 0.1 mol %.

The present disclosure relates to an optochemical sensor element comprising: a substrate layer having a first substrate side facing toward a measurement medium and an opposite second substrate side; a functional layer, on the first substrate side and having a first reference dye, an indicator dye, and a second reference dye, wherein the first reference dye comprises an inorganic material, is insensitive to pH, and is suitable to emit a first luminescence signal upon stimulation, wherein the indicator dye comprises an organic material and is sensitive to pH, and is suitable to emit a third luminescence signal upon stimulation, wherein the second reference dye comprises an organic material, is insensitive to pH, and has a passivated functional group, and is suitable to emit a second luminescence signal upon stimulation, wherein the substrate layer is transparent to the stimulation signal and the luminescence signals.

A method for treating a plurality of indicator fields for determining the pH-value of an aqueous solution is provided. Each of the indicator fields contains at least one indicator dye, which is fixed in a non-bleeding manner, in particular on a layer including cellulose or regenerated cellulose, and changes its color within a pH-turning-range. The indicator fields having buffer capacities which differ from one another. All the indicator fields are impregnated from the outside with an impregnation which influences the buffer capacities of the indicator fields in such a way that the deviations are levelled.