A method for automated identification of a state of a sample such as, for example, for identifying whether or not the sample was centrifuged is presented. A device for analyzing samples and a laboratory automation system are also presented in which the method is applied.

The present invention utilizes a high throughput testing (HTT) method of high performance liquid chromatography (HPLC) to validate samples of pharmaceutical compositions. In one embodiment, improved sample preparation techniques comprise adding the entire vial of a sample to a wide mouth disposable bottle, adding diluent, shaking overnight, and centrifuging.

A method for measuring a concentration of molecules, characterized in that the method measures the concentration of molecules dissolved in a continuous phase of a colloid and includes obtaining a test sample by mixing a number of molecules with a volume of colloid, obtaining a control sample by mixing a number of molecules with a volume of a composition comprising a particle-free solution extracted from a fraction of the continuous phase of same colloid used in the obtaining the test sample, so that a value of the concentration of molecules in the mixture is equal to the value of the concentration of molecules in the test sample obtained in the obtaining the test sample, and submitting the test and the control samples obtained in the obtaining the test sample and obtaining the control sample to a process in order to concentrate the particles of the test sample.

Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

A substrate for sample analysis including: a substrate including a rotation axis; a first chamber, which includes a first space which retains the liquid; a second chamber, which includes a second space which retains the liquid discharged from the first chamber; and a first flow passage, which includes a path connecting the first chamber and the second chamber in which the first flow passage has a first opening and a second opening, the first opening and the second opening are connected to the first chamber and the second chamber, respectively, and the first opening is positioned on a side closer to the rotation axis than the second opening, in which the first space includes a first region, which includes a portion extending from the first opening and in which the first space of the first chamber has a capacity larger than a capacity of the first flow passage.

A rotor assembly includes a rotor plate to rotate around a first axis, a bucket attached to the rotor plate and to rotate around a second axis, and a stop plate to rotate around the first axis between an open position and a closed position. When in the closed position, the stop plate engages the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly. The rotor assembly further includes a housing for a sensor array component, the housing disposed in the bucket and including a solution inlet, a solution outlet, a transfer basin, a solution retainer disposed between the solution outlet and the transfer basin, and a collection reservoir in fluid communication with the transfer basin. The solution inlet and the solution outlet to engage ports of a flow cell of a sensor array.

The present invention discloses a kind of centrifugal detection channel, including: a first chamber, at least one inlet channel, at least one buffer valve, at least one outlet channel, and a second chamber. Specifically, at least one inlet channel is connected to the first chamber. At least one buffer valve is connected to the inlet channel, including: a valve body and a transient chamber. At least one outlet channel is connected to the buffer valve. At least one second chamber is connected to the outlet channel. In addition, the detection devices and the detection methods comprising the centrifugal detection channel have also been proposed.

A sample analysis substrate includes a substrate; a first holding chamber; a reaction chamber; a first flow path having a first opening and a second opening respectively connected with the first holding chamber and reaction chamber; a main chamber; a second flow path having a third opening and a fourth opening respectively connected with the reaction chamber and the main chamber; and a magnet accommodation chamber capable of accommodating a magnet. The first opening is located closer to a rotation shaft than the second opening. The second opening is located closer to the rotation shaft than the third opening. The magnet accommodation chamber is located at a position at which, in the case where the magnet is accommodated in the magnet accommodation chamber, the magnet captures magnetic particles in the main chamber. The sample analysis substrate is rotatable to transfer a liquid.

A pretreatment apparatus includes a sample dispensing part 240, a reagent dispensing part 280 for dispensing a labeling reagent, a first process part 210 having a centrifuge device for performing a centrifugation process, a second process part 220, and a control part for distributing the dispensing destination of the sample to either the first sample container 217 or the second sample container 227 according to whether centrifugation process is required for the sample.

A liquid analyzing device includes a carrier, a driving unit, a rotating plate and a transmission mechanism. The driving unit is adapted to drive the carrier to rotate. The rotating plate is rotatably disposed on the carrier and adapted to support an analyzing cassette. The transmission mechanism is connected between the carrier and the rotating plate. When the driving unit drives the carrier to rotate to enable a rotation speed of the carrier to be changed and cross a predetermined rotation speed, the rotating plate rotates relatively to the carrier.