Provided is a signal processing apparatus including a first measurement unit which acquires a first time-series signal with a first time resolution; a second measurement unit which acquires a second time-series signal with a second time resolution higher than the first time resolution; and a determination unit which determines a measurement abnormality based on the second time-series signal. The normal measurement is performed based on the first time-series signal while the measurement abnormality determination is performed based on the acquired second time-series signal.

The present disclosure provides an automatic microfluidic system for rapid personalized drug screening including a microfluidic chip. The microfluidic chip includes a fluid storage unit, a fluid driving unit, a reaction unit and a plurality of valve units. The fluid driving unit includes two mixing pumps. Each of the mixing pumps includes two pneumatic micro-pumps, a mixing chamber and a blocking structure. The blocking structure is disposed in the mixing chamber and is connected between the two pneumatic micro-pumps. When the two pneumatic micro-pumps are started alternately, the blocking structure is deflected alone with the operation of the two pneumatic micro-pumps.

An ion mobility spectrometer analytical instrument, including an ion mobility spectrometer, a swab interface, and a desorber assembly. The desorber assembly includes a heat transfer device configured to heat a desorber, as well as a supply configured to direct gas through the desorber. The instrument further includes a drift tube, high voltage device arrayed, at least in part, proximate to the drift tube, wherein the high voltage device is configured to change a polarity of a voltage applied to the drift tube and have an absolute voltage of about 500 to 1500 volts. The instrument further includes a reactant supply unit adapted to supply reactant during a sample substance analysis, and a control unit.

The present disclosure relates to a method of operating an automatic analysis apparatus for determining a parameter of a sample liquid which depends on the concentration of an analyte in the sample liquid on the basis of a first measurement variable detected by the analysis apparatus, wherein the analysis apparatus comprises an optical measuring transducer with a measurement unit, the method including: a) providing a reaction mixture comprising the sample liquid in the measurement unit; b) detecting a first measurement variable for determining the parameter; c) detecting a second measurement variable if step b) reveals that the concentration of the analyte in the reaction mixture is outside the measuring range of the analysis apparatus for detecting the first measurement variable; d) diluting the reaction mixture with dilution liquid as a function of the second measurement variable; and e) re-detecting the first measurement variable for determining the parameter.

When the automatic analyzer is installed in an environment with a high altitude and different external atmospheric pressures, there is a problem that an amount of vacuum suction decreases due to a decrease in suction performance of a vacuum pump and it is difficult to perform vacuum suction of an analyzed reaction liquid. In view of the above, by newly providing a pressure adjustment mechanism within a flow path connecting a vacuum tank to vacuum pump, it possible to control the pressure difference between a pressure in the vacuum tank and an external atmospheric pressure where the analyzer is installed to be constant regardless of the installation environment. Additionally, by providing a hole in communication with the outside in the vacuum tank or a vacuum bin, it possible to control the pressure difference between the pressure in the vacuum tank and the external atmospheric pressure where the analyzer is installed to be constant regardless of the installation environment.

A needle for forming a cut in a reagent bottle lid is shaped such that an expansion portion which pushes and opens a cut and a piercing portion which forms the cut are integrated with each other. Consequently, only a single operation for moving the needle downwardly will form a cut using the needle and expand the cut using the expansion portion. Further, the smaller diameter of the expansion portion than the diameter of a circumscribed circle of a cross section of the piercing portion but equal to or greater than the diameter of the reagent probe can form cuts uniformly.

The disclosed system discussed herein may include systems and methods for the automated intake and analysis of biological samples. The system may receive, by a drawer of a testing device, a sample holder comprising a biological sample. The system may transport, by a robotic manipulator, the sample holder from the sample drawer to a slot within a repository. The system may maintain a predefined temperature within the repository during a growth period of the biological sample. The system may move the sample holder to an optic assembly. The system may remove, by the robotic manipulator, a coverslip from the sample holder. The system may capture, an image of the biological sample. The system may determine one or more characteristics of the biological sample. The system may execute, based on the one or more characteristics, one or more actions.

A drawer apparatus for diagnostic devices can include a body configured to form a sample receiving compartment for housing a diagnostic sample. The drawer apparatus can further include a gear rack directly affixed to the body and meshing with a drive mechanism. The drawer apparatus can further include a constant force spring mechanism coupled with the gear rack. The drawer apparatus can further include a rotary damper. The drawer apparatus can further include a latch solenoid. The drawer apparatus can further include a drawer closed sensor.

The automatic analyzer includes: a sample dispensing unit that dispenses a sample into a reaction vessel; a reagent dispensing unit that dispenses a reagent into the reaction vessel; a control unit that controls the sample dispensing unit and the reagent dispensing unit; and a measurement unit that measures a mixed solution of the sample and the reagent mixed in the reaction vessel. The reagent includes three types of reagents of: a first reagent that specifically binds to an antigen in the sample; a second reagent that specifically binds to a site different from that to which the first reagent binds with respect to the antigen and has a label to be detected by the measurement unit; and a third reagent that specifically binds to a site different from the binding site of the first reagent and the antigen and contains insoluble carriers.

The present disclosure provides an automatic microfluidic system for rapid personalized drug screening including a microfluidic chip. The microfluidic chip includes a fluid storage unit, a fluid driving unit, a reaction unit and a plurality of valve units. The fluid driving unit includes two mixing pumps. Each of the mixing pumps includes two pneumatic micro-pumps, a mixing chamber and a blocking structure. The blocking structure is disposed in the mixing chamber and is connected between the two pneumatic micro-pumps. When the two pneumatic micro-pumps are started alternately, the blocking structure is deflected alone with the operation of the two pneumatic micro-pumps.