A system and method are described that allow the autonomous collection of relevant data and samples from a patient during a clinical trial or during routine care. Sampling is accomplished by drawing multiple samples into tubing, such as microfluidic tubing, and using a pump to move the samples through the tubing. A spacer fluid is provided to separate each sample and to prevent contamination between each. A microcontroller is used to control the operation of the pump and to gather data about the patient from the electronic medical record or other alternative inputs, and the sampling, including data from onboard sensors.

To provide a sample analysis device for speedily and accurately analyzing a plurality of items for a fluid to be measured, a biochemical analysis device comprises: a measurement unit that captures images of and obtains image information about each reaction between a target fluid and a plurality of types of antigen; a storage unit that stores antigen position information for the plurality of types of antigen fixed in a microchannel; and a determination unit that determines a plurality of items for a specimen, based on the antigen position information and the image information. The storage unit stores arrangement state determination information for determining the arrangement state of analysis chips. The determination unit determines the arrangement state of the analysis chips during imaging, based on the arrangement state determination information and the image information, and analyses the specimen based on the antigen position information and the image information.

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

Dispersion injection methods for determining biomolecular interaction parameters in label-free biosensing systems are provided. The methods generally relate to the use of a single analyte injection that generates a smoothly-varying concentration gradient via dispersion en route to a sensing region possessing an immobilized binding partner. The present method incorporates the use of an internal standard which provides a reference as to the dispersion conditions present which can then be used to calculate an effective diffusion coefficient for the analyte of interest based on a universal calibration function. The effective diffusion coefficient can then be incorporated into the appropriate dispersion model to provide a calibrated dispersion model. The calibrated dispersion model can then be incorporated into the desired interaction model to provide a reliable representation of the analyte concentration at the sensing region at any time during the injection. The use of the internal standard and universal calibration function permit use of a wide range of injection conditions which may not otherwise be consistent with a particular dispersion model. Thus, the present methods allow for higher flow rates and lower sample volumes thereby increasing assay speed and decreasing sample consumption.

Disclosed is a method of processing a specimen in which a target component in a specimen is processed using a specimen processing chip provided with a flow-path, the method including: introducing a fluid into a flow-path to form an interface that divides the fluid from a process liquid used for the processing of the target component with a rim of the interface on an inner wall of the flow-path, the process liquid containing particles including the target component; and moving the formed interface along the flow-path with the rim of the interface on the inner wall so as to force out the particles retained in the process liquid by the fluid.

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization.