The present invention improves the technology for detecting the level of a reagent in a container using changes of the capacitance, for instance, of an aspiration tube for aspirating the reagent from the container. The present invention can eliminate noises to detection of the capacitance caused by metals surrounding the container and changes of the moving speed of aspiration tube. Changes of the capacitance are detected using an empty container and recorded. The recorded changes are subtracted from changes of the capacitance measured with a container containing a reagent to eliminate the noises to the detection of changes of the capacitance.

It is possible to maintain, in clean condition, a solenoid valve for discharge of cleaning fluid accumulated in a vacuum bottle in which the cleaning fluid adhering to a probe collects. An automatic analyzer includes: a cleaning bath that has a cleaning fluid outlet from which cleaning fluid is discharged for cleaning a probe, and a vacuum suction port into which the probe is inserted; a cleaning tank that stores the cleaning fluid; a vacuum tank; a vacuum pump that causes the vacuum tank to be placed under negative pressure with respect to atmospheric pressure; a vacuum bottle placed between the vacuum suction port and the vacuum tank; and, as channels through which the cleaning fluid flows into the vacuum bottle, a first channel connected to the vacuum suction port and a second channel connected to the cleaning tank.

An automatic analyzing apparatus capable of eliminating static electricity charged in a specimen container at a specimen dispensing position provided. The automatic analyzing apparatus includes a dispensing mechanism having a probe that aspirates a liquid and an arm that holds the probe, and a static eliminator having a generation source of neutralizing ions and a neutralizing ion blowing mechanism for blowing the neutralizing ions generated in the generation source to a target, which are provided in the dispensing mechanism.

An instrument for processing a biological sample includes a chassis. Connected to the chassis is a tape path along which a tape with a matrix of wells can be automatically advanced through the instrument, a dispensing assembly for dispensing the biological sample and a reagent into the matrix of wells of the tape to form a biological sample and reagent mixture, a sealing assembly for sealing the biological sample and reagent mixture in the tape, and an amplification and detection assembly for detecting a signal from the biological sample and reagent mixture in the matrix of wells in the tape.

To clean a reagent probe 7a, 8a or a sample probe 11a, 12a with a heated cleaning solution, after a first cleaning solution is caused to overflow from a first cleaning container 23 or a second cleaning container 24, the first cleaning solution is temporarily drawn back into the cleaning-solution heating passage 125 to be heated by the heating mechanism 123. After the heating, the first cleaning solution thus heated is re-supplied to the first cleaning container 23 or the second cleaning container 24. As a result, the cleaning solution heated to clean a dispensing probe can be supplied to a cleaning bath with efficiency.

Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement. Further, the automated analysis device 100 includes a controller 21 which controls the drive of the reaction disk 1 such that in one cycle the reaction vessels 2 move by an amount A in the circumferential direction in such a way that N and A are mutually prime, B and C are mutually prime, and the relationship A×B=N×C±1 holds, where N is the total number of reaction vessels 2 accommodated in the reaction disk 1, the reaction disk 1 moves through C (where C>1) rotations+an amount equivalent to one reaction vessel after B (where B>2) cycles, and the number of reaction vessels 2 moved in one cycle is A (where N>A>N/B+1).

The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.

A clinical diagnostic sample analyzer for analyzing a sample of a patient is disclosed. The analyzer includes a telescoping closed-tube sampling assembly with a sample probe concentrically housed within a piercing probe and a venting mechanism. The closed-tube sampling assembly is used for aspirating a sample from a sample tube for analysis by a clinical diagnostic sample analyzer.

An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.

A medical diagnostic system is provided to automate analysis of samples to predict a medical condition, such as pregnancy or chronic kidney disease. The system may provide test strip usage automation. The medical diagnostic system may include a sample collection component, collection cup contamination protection mechanism, sample volume control component, test strip reader component, which may be manifested as a lateral flow strip reader, flow reader, sample analytic component, data processing component, data communication component, networked data management component, and device cleaning mechanism. A method to automate analysis of samples to predict a medical condition using the medical diagnostic system is also provided.