The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. The HTP genomic engineering platform described herein is microbial strain host agnostic and therefore can be implemented across taxa. Furthermore, the disclosed platform can be implemented to modulate or improve any microbial host parameter of interest.

Automated pipetting systems and methods are disclosed for aspirating and dispensing fluids, particularly biological samples. In one aspect, a liquid dispenser includes a manifold and one or more pipette channels. The manifold includes a vacuum channel, a pressure channel, and a plurality of lanes. Each lane includes an electrical connector, a port to the pressure channel, and a port to the vacuum channel. The pipette channels can be modular. Each pipette channel includes a single dispense head and can be selectively and independently coupled to any one lane of the plurality of lanes. In some aspects, a valve in the pipette channel is in simultaneous fluid communication with a pressure port and a vacuum port of the manifold. The valve selectively diverts gas under pressure and gas under vacuum to the dispense head in response to control signals received through the electrical connector of the manifold.

The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. The HTP genomic engineering platform described herein is microbial strain host agnostic and therefore can be implemented across taxa. Furthermore, the disclosed platform can be implemented to modulate or improve any microbial host parameter of interest.

A device and method for supplying multiple work-cell bound analyzers as well as multiple cores of a single analyzer with patient samples, reagents, consumables comprising a track device that are located in the middle between or at one side of analyzer and cores.

A liquid chromatography sample manager includes a thermal chamber, a sample platter mounted in the thermal chamber, and a needle drive including a base having a shaft configured to rotate about a vertical axis, the base attachable to an interior of a sample manager of a liquid chromatography system. The needle drive further includes a needle assembly attached to the base, the needle assembly including a sample needle, and a drive system attached to the base, the drive system including a sample needle motor configured to impart vertical movement of the sample needle. The liquid chromatography sample manager further includes a sample delivery system configured to transfer a first sample from a first sample vial carrier located in the sample platter into a chromatographic flow stream.

Automated pipetting systems and methods are disclosed for aspirating and dispensing fluids, particularly biological samples. In one aspect, a liquid dispenser includes a manifold and one or more pipette channels. The manifold includes a vacuum channel, a pressure channel, and a plurality of lanes. Each lane includes an electrical connector, a port to the pressure channel, and a port to the vacuum channel. The pipette channels can be modular. Each pipette channel includes a single dispense head and can be selectively and independently coupled to any one lane of the plurality of lanes. In some aspects, a valve in the pipette channel is in simultaneous fluid communication with a pressure port and a vacuum port of the manifold. The valve selectively diverts gas under pressure and gas under vacuum to the dispense head in response to control signals received through the electrical connector of the manifold.

Automated pipetting systems and methods are disclosed for aspirating and dispensing fluids, particularly biological samples. In one aspect, a liquid dispenser includes a manifold and one or more pipette channels. The manifold includes a vacuum channel, a pressure channel, and a plurality of lanes. Each lane includes an electrical connector, a port to the pressure channel, and a port to the vacuum channel. The pipette channels can be modular. Each pipette channel includes a single dispense head and can be selectively and independently coupled to any one lane of the plurality of lanes. In some aspects, a valve in the pipette channel is in simultaneous fluid communication with a pressure port and a vacuum port of the manifold. The valve selectively diverts gas under pressure and gas under vacuum to the dispense head in response to control signals received through the electrical connector of the manifold.

A laboratory system includes: at least one reactor; a sample extraction device for extracting a sample from the at least one reactor into a sampling space; a fluid supply system including a transportation fluid supply; at least one sample storage container; at least one fluid supply channel connecting the extraction device to the fluid supply system; at least one sample extraction channel connecting the extraction device to the sample storage container, where the fluid supply system is arranged to push the sample from the sampling space through the sample extraction channel to the at least one sample storage container using transportation fluid of the transportation fluid supply.

A dispensing device 400 includes a plurality of dispensing nozzles arranged at predetermined intervals in x and y directions, a dispensing body 430 configured to support the plurality of dispensing nozzles, a mounting body 144 configured to allow a plurality of dispensing tips 142 to be mounted on the mounting body 144 at the predetermined intervals in the x and y directions, an attaching mechanism 432, 144b configured to attach the mounting body 144, on which the plurality of dispensing tips 142 are mounted, to the plurality of dispensing nozzles to install the plurality of dispensing tips 142 on the plurality of dispensing nozzles, a removing mechanism configured to remove the plurality of dispensing tips and the mounting body 144 from the plurality of dispensing nozzles, and a control unit configured to control operations of the plurality of dispensing nozzles, the attaching mechanism, and the removing mechanism.

A positioning system for positioning a consumable rack in a diagnostic system is disclosed. The positioning system comprises a rack comprising an upper surface comprising holding positions and a receiving compartment comprising a rectangular chassis comprising front, rear, and two lateral sides. The receiving compartment comprises a holding structure coupled to the chassis to move between first and second positions. The rack comprises sidewalls. At least three sidewalls have a center alignment element. The chassis comprises three chassis alignment elements on the rear and two lateral sides. The holding structure comprises a corner push element between the chassis front and lateral sides to push against a side edge of the rack between two sidewalls when the holding structure is moved from the first position towards the second position forcing the three alignment elements against a chassis alignment element and laterally holding the rack in position by the chassis alignment elements.