The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. The HTP genomic engineering platform described herein is microbial strain host agnostic and therefore can be implemented across taxa. Furthermore, the disclosed platform can be implemented to modulate or improve any microbial host parameter of interest.

A transfer device (2) and a method for transferring at least one functional element (3) into a process chamber (4) are provided, wherein the at least one functional element (3) is arranged interchangeably on an element carrier (5) and the element carrier (5) is transferable from a starting position (6) into an end or working position (7), wherein, in the end or working position (7), the at least one functional element (3) is arranged partly in the process chamber (4) and partly outside the process chamber (4). The invention is therefore particularly suitable for aseptic processes in the pharmaceutical industry, but is not limited to this sphere.

Automated pipetting systems and methods are disclosed for aspirating and dispensing fluids, particularly biological samples. In one aspect, a liquid dispenser includes a manifold and one or more pipette channels. The manifold includes a vacuum channel, a pressure channel, and a plurality of lanes. Each lane includes an electrical connector, a port to the pressure channel, and a port to the vacuum channel. The pipette channels can be modular. Each pipette channel includes a single dispense head and can be selectively and independently coupled to any one lane of the plurality of lanes. In some aspects, a valve in the pipette channel is in simultaneous fluid communication with a pressure port and a vacuum port of the manifold. The valve selectively diverts gas under pressure and gas under vacuum to the dispense head in response to control signals received through the electrical connector of the manifold.

A sample analyzer includes a reaction wheel, a first reagent container storage mechanism, a second reagent container storage mechanism, a reagent container buffering mechanism, and a reagent container transfer mechanism. In the present disclosure, a center line is defined by extending from a first rotation center to a second rotation center, and the reagent container buffering mechanism and the reaction wheel are respectively located on two sides of the center line. The reagent container transfer mechanism is configured to transfer reagent containers between the first reagent container storage mechanism and the reagent container buffering mechanism, and/or between the second reagent container storage mechanism and the reagent container buffering mechanism.

A sample producing apparatus produces an observation sample by placing an observation target object on a surface of a liquid pool on an optically transparent plate and then removing the liquid pool. The sample producing apparatus comprises a holding means for holding the plate, and a tilting means for tilting the plate such that the liquid pool on the plate is flowed. According to the sample producing apparatus, the working efficiency when producing the observation sample is improved.

A device for dispensing fluid for testing including a tube having a proximal end and a distal end, a cylindrical holding mechanism, and a plunger. The cylindrical holding mechanism includes an outer holding part for holding the tube within the outer holding part, an inner holding part configured to engage with the outer holding part, wherein one end of the inner part holding part is connected to a handle assembly, and a circumferential grip ring disposed between the outer holding part and the inner holding part to provide a differential resistive force at each side of the circumferential grip ring, wherein the tube extends through the inner holding part and the outer holding part. The plunger is configured to dispense the fluid contained in the tube.

The present application discloses a method for controlling the liquid inflow of a liquid path system, a liquid path system, a sequencing apparatus, a computer device, and a computer storage medium. The method includes: using a pump valve assembly to aspirate a plurality of samples under test from a sample cartridge and pump each sample under test from an outlet of one corresponding fluid channel into the fluid channel; or using the pump valve assembly to aspirate a single sample under test from the sample cartridge and pump the single sample under test from an inlet of each fluid channel into the fluid channel. In this way, different sample loading modes can be selected according to the number of the samples under test, improving the loading flexibility of the samples under test. In addition, by allowing each of the plurality of samples under test to enter from the outlet of one corresponding fluid channel into the fluid channel, the cross-contamination among the plurality of samples under test is avoided, and the sequencing quality and the sequencing efficiency are improved.

A pipette includes a capillary, a pressure chamber, a drive unit, and a control unit. The capillary has a first end and a second end that are two ends in a length direction and that are open. The pressure chamber communicates with an inside of the capillary via the second end. The drive unit changes a volume of the pressure chamber. The control unit controls the drive unit. The control unit outputs a vibrational movement signal that drives the drive unit so that a liquid moves from a mid-position in the capillary to a finish position that is located closer to the second end than the mid-position. The vibrational movement signal has a waveform that drives the drive unit so that the volume of the pressure chamber alternately increases and decreases repeatedly.

An automatic sampling equipment includes a sampling bottle and an automatic sampling module. The sampling bottle includes a cap and a body. The automatic sampling module is utilized to hold the sampling bottle for sampling a chemical liquid. In addition, the automatic sampling module includes a sampling bottle holder and a cap rotating device. The sampling bottle holder is utilized to hold the body of the sampling bottle, and the cap rotating device is equipped above the sampling bottle holder to open or close the cap of the sampling bottle. Furthermore, an automatic sampling method is also disclosed herein.

A sample producing apparatus produces an observation sample by placing an observation target object on a surface of a liquid pool on an optically transparent plate and then removing the liquid pool. The sample producing apparatus comprises a holding means for holding the plate, and a tilting means for tilting the plate such that the liquid pool on the plate is flowed. According to the sample producing apparatus, the working efficiency when producing the observation sample is improved.