The invention provides a biomolecular image sensor with a plurality of microstructures repeatedly arranged on a surface of an image sensing element, and method thereof for detecting biomolecule.

A method for measuring optical signal detector performance that includes directing light emitted from an optical signal detector onto a first non-fluorescent surface portion in a first detection zone of the optical signal detector. A first characteristic of light detected by a first sensor of the first optical signal detector is measured while the first non-fluorescent surface portion is in the first detection zone of the optical signal detector. Light emitted from the optical signal detector is directed into a first void in the first detection zone of the optical signal detector. A second characteristic of light detected by the first sensor of the optical signal detector is measured while the first void is in the first detection zone of the optical signal detector. And an operational performance status of the optical signal detector is determined based on at least one of the first characteristic and the second characteristic.

To reduce optical noise in fluorescence measurement. A biochip 110 for fluorescence measurement includes a transparent substrate 111, multiple microlenses 112 dispersively formed on a first surface 111a of the transparent substrate 111, multiple protruding portions 113 formed corresponding one-to-one with the microlenses 112 on a second surface 111b of the transparent substrate 111, and a fluorescence measurement site 114 formed at a top portion of each protruding portion 113.

To reduce optical noise in fluorescence measurement. A biochip 110 for fluorescence measurement includes a transparent substrate 111, multiple microlenses 112 dispersively formed on a first surface 111a of the transparent substrate 111, multiple protruding portions 113 formed corresponding one-to-one with the microlenses 112 on a second surface 111b of the transparent substrate 111, and a fluorescence measurement site 114 formed at a top portion of each protruding portion 113.

A plasmonic waveguide (10), a biosensor chip (100) and a system, wherein the plasmonic waveguide (10) is applied to the biosensor chip (100), and comprises a base (11) and a plasmonic structure (12) provided on the upper surface of the base (11); the plasmonic structure (12) comprises a plurality of plasmons (121) periodically arranged, the plasmons (121) being metal split rings, and the annular openings of the plasmons (121) being used for fixing antibody probes (122). The plasmon waveguide (10) is provided in the biosensor chip (100), the target biomolecules in the detection liquid flowing into a microfluidic channel (31) can be captured by means of the antibody probes (122), and the plasmonic waveguide (10) is used to enhance the signal strength of terahertz waves emitted to the biosensor chip (100), thereby enhancing the signal strength of the reflected terahertz waves detected by a terahertz analyzer (300), improving the detection sensitivity, the signal-to-noise ratio and the reliability.

The present invention provides a LAMP assay device comprising a heating chamber (5) adapted to receive a support rail (2) of at least one sample, in which the support rail (2) is inserted into it through a sample insertion opening (1), in addition, the heating chamber (5) comprises: at least one internal heating element (8a, 8b); a circuit of light-emitting elements (6) positioned on a front or rear wall; and a light sensor circuit (7) on a wall opposite the light emitting element circuit (6).

A plasmonic waveguide (10), a biosensor chip (100) and a system, wherein the plasmonic waveguide (10) is applied to the biosensor chip (100), and comprises a base (11) and a plasmonic structure (12) provided on the upper surface of the base (11); the plasmonic structure (12) comprises a plurality of plasmons (121) periodically arranged, the plasmons (121) being metal split rings, and the annular openings of the plasmons (121) being used for fixing antibody probes (122). The plasmon waveguide (10) is provided in the biosensor chip (100), the target biomolecules in the detection liquid flowing into a microfluidic channel (31) can be captured by means of the antibody probes (122), and the plasmonic waveguide (10) is used to enhance the signal strength of terahertz waves emitted to the biosensor chip (100), thereby enhancing the signal strength of the reflected terahertz waves detected by a terahertz analyzer (300), improving the detection sensitivity, the signal-to-noise ratio and the reliability.

A transmission device for examining at least one sample in a microtiter plate, the transmission device including: an illumination device; and a detection device, an intermediate space being formed between the illumination device and the detection device, the intermediate space being configured to receive a microtiter plate. The illumination device including at least one emission source, the illumination device being configured to guide emission light generated by the emission source through the intermediate space. The detection device including at least one detector configured to measure light signals received from the intermediate space; and the detection device includes an angle-dependent filter arranged between the illumination device and the at least one detector in a beam path of the emission light, the angle-dependent filter being configured to substantially only let through light beams having an angle of incidence smaller than a predetermined critical angle.

A system for conducting an assay comprises a power source (16), a controller (13) for controlling the assay and a plurality of assay units (14) operatively connected to one another such that the controller can communicate with the assay units and the system is capable of conducting the assay. An assay device comprises a substantially circular body (24) having a plurality of chambers in fluid connection such that fluid can pass between said chambers and a central hub (200) having a sample inlet (202) disposed therein for receiving a sample.

This application provides a tab image acquisition device, system, and method. The tab image acquisition device includes an image acquisition apparatus, where the image acquisition apparatus includes: a first mobile module movable in a first direction; a second mobile module movable in a second direction, where the second mobile module is installed on the first mobile module and the second direction intersects the first direction; an image acquisition module installed on the second mobile module; and a prism module installed on the first mobile module, where the prism module has a reflective surface, and the reflective surface is configured to change an angle of incident light on a tab whose image is to be acquired, so that the incident light enters the image acquisition module.