A microdevice includes: a microchannel to which a measurement target solution containing a measurement target substance is introduced; an antibody being fixed to at least one sidewall surface of the microchannel and specifically binding to the measurement target substance; a fluorescence-labeled derivative being specifically bound to the antibody and being acquired by fluorescence-labeling the measurement target substance; and a light blocker blocking excitation light exciting fluorescent light radiated by the fluorescence-labeled derivative. The measurement target substance and the fluorescence-labeled derivative specifically bind to the antibody in a competitive manner, and the antibody is fixed to the sidewall surface of the microchannel in a state of specifically binding to the fluorescence-labeled derivative. The light blocker blocks the excitation light entering the fluorescence-labeled derivative specifically binding to the antibody.

An integrated device and related instruments and systems for analyzing samples in parallel are described. The integrated device may include sample wells arranged on a surface of where individual sample wells are configured to receive a sample labeled with at least one fluorescent marker configured to emit emission light in response to excitation light. The integrated device may further include photodetectors positioned in a layer of the integrated device, where one or more photodetectors are positioned to receive a photon of emission light emitted from a sample well. The integrated device further includes one or more photonic structures positioned between the sample wells and the photodetectors, where the one or more photonic structures are configured to attenuate the excitation light relative to the emission light such that a signal generated by the one or more photodetectors indicates detection of photons of emission light.

Certain embodiments are directed to a low-cost battery-powered spectrophotometric system (BASS) coupled with a microfluidic chip for POC analysis, as well as methods of using the same.

Methods for detecting defects on the surface of a sheet of material include collimating a beam of light and intersecting the collimated beam of light with a beam splitter. The beam splitter directs a first portion of the intersected beam of collimated light to illuminate a first surface of the sheet, wherein a first portion of the light illuminating the first surface is reflected and a second portion of the illuminating light is scattered by a defect. The reflected and scattered light is received with a first lens element that directs the reflected and scattered light to an inverse aperture. The reflected light is blocked by the inverse aperture and the scattered light is transmitted by the inverse aperture. The scattered light transmitted by the inverse aperture is directed with a second lens element to an imaging device.

Improved colorimetric analysis of liquid samples is provided. A sample holder is used that delivers predetermined volumes of sample individually to each of several colorimetric test patches at the same time with a sliding action. An opaque housing is employed to prevent ambient light from reaching the test patches when color images of the test patches are acquired. Preferably, a mobile electronic device including a camera is attached to the opaque housing to acquire the images. Optical microscopy can be performed in addition to the colorimetric analysis.

The disclosure provides microstructured articles and methods useful for detecting an analyte in a sample. The articles include microwell arrays. The articles can be used with an optical system component in methods to detect or characterize an analyte.

An analyzer and a detection system are provided. The analyzer includes a chip placement structure and at least one detector unit. The chip placement structure is configured to place a detection chip, and the detection chip is provided with at least one detection area. The at least one detector unit is configured to detect one or more detection areas of the detection chip in a case where the detection chip is placed on the chip placement structure.

A test device includes a specimen having a circular cross section that accommodates a test target, a specimen holding part that holds a plurality of the specimens in a row, light emitting elements in which light is incident on two adjacent specimens among the plurality of specimens, a first light guide path 46 that guides light emitted by the light emitting elements, and a second light guide path that is formed to have a smaller diameter than a diameter of the first light guide path and that guides the light emitted by the light emitting elements from the first light guide path to the specimen.

In order to provide a biological sample analysis apparatus capable of preventing a container storing a sample from being charged and of measuring only a luminescence intensity of light emitted from the sample accurately, a biological sample analysis apparatus for rapid microbiological test analyzes light generated from a biological origin substance contained in a sample, and includes a holder that holds a plurality of containers storing the sample, a photodetector fixed at a predetermined position, a holder drive mechanism that drives the holder and sequentially positions each of the containers held by the holder at a detection position detected by the photodetector, and a neutralizer that neutralizes the containers held by the holder.

The present invention provides a far-infrared light source capable of reducing the shift in the location irradiated with far-infrared light even when the frequency of the far-infrared light changes. A far-infrared light source according to the present invention is configured so that the variation in the emission angle of far-infrared light in a nonlinear optical crystal when the frequency of the far-infrared light changes is substantially offset by the variation in the refractive angle of the far-infrared light at the interface between the nonlinear optical crystal and a prism when the frequency of the far-infrared light changes (see FIG. 8).