A polarization property image measurement device includes: a first radiation unit that radiates light beams in different polarization conditions onto a target object after subjecting the light beams to intensity modulation at frequencies different from one another; a light receiving unit including first photoelectric conversion units that photoelectrically convert the light beams having been radiated from the first radiation unit and scattered at the target object in correspondence to each of the different polarization conditions, and second photoelectric conversion units that photoelectrically convert visible light from the target object; and a processor that detects signals individually output from the first photoelectric conversion units at the different frequencies and differentiates each signal from other signals so as to determine an origin of the signal as one of the light beams; and creates an image of the target object based upon signals individually output from the second photoelectric conversion units.

Embodiments of the present disclosure are directed to a compact, mobile, digital spatial profiling (DSP) system, and associated apparatuses, devices and methods, which are configured to image one or more regions-of-interest (ROIs), and then using UV light to cleave, for example, oligos off antibodies in one or more ROIs (“photocleaving”), and collect the photocleaved oligos for later hybridization and counting.

One illustrative device disclosed herein includes a semiconductor substrate, a channel that is at least partially defined by at least a portion of the semiconductor substrate, an input fluid reservoir and an output fluid reservoir, wherein the channel is in fluid communication with the input fluid reservoir and the output fluid reservoir. In this example, the device further includes a first radiation source operatively coupled to the substrate, wherein the first radiation source is adapted to generate radiation in a direction toward the channel, and at least one photodiode positioned adjacent the channel.

A light generator including a light source, an optical switch that controls ON/OFF of light from the light source, and a mirror that reflects light from the optical switch and sends the light back to the optical switch. A light generator less in residue in fitting of a ring-down signal, and a radioactive carbon dioxide isotope analysis device and a radioactive carbon dioxide isotope analysis method, by use of the light generator are provided.

A miniature full analysis device and a manufacturing method therefor are provided, the miniature full analysis device includes: a substrate; a main channel extending in a first direction; at least one secondary channel extending in a second direction intersecting the first direction, one end of the secondary channel is connected to the main channel, and the secondary channel is configured to be switched between a first state in which the detection light does not enter the secondary channel and a second state in which the detection light enters the secondary channel, and is transmitted in the second direction, the other end of the secondary channel has a reflective surface which is configured to reflect the detection light to a microfluidic sensing layer which is configured to carry a liquid to be analyzed and to detect the detection light passing through the liquid to be analyzed.

An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.

According to the present disclosure, an optical signal emitted from a single molecule is received to measure a central location of the single molecule while changing a phase of a structured illumination having a periodic pattern to measure a phase of a pattern in which a fluorescence intensity is periodically changed in accordance with a distance between the pattern and the single molecule while displacing the periodic pattern by a specific interval to measure the central location of the single molecule, thereby improving an accuracy of the central location of the single molecule with low photons and as a result, the resolution of the image may be enhanced.

A miniature full analysis device and a manufacturing method therefor are provided, the miniature full analysis device includes: a substrate; a main channel extending in a first direction; at least one secondary channel extending in a second direction intersecting the first direction, one end of the secondary channel is connected to the main channel, and the secondary channel is configured to be switched between a first state in which the detection light does not enter the secondary channel and a second state in which the detection light enters the secondary channel, and is transmitted in the second direction, the other end of the secondary channel has a reflective surface which is configured to reflect the detection light to a microfluidic sensing layer which is configured to carry a liquid to be analyzed and to detect the detection light passing through the liquid to be analyzed.

According to one embodiment, a particle measuring method is disclosed. The method includes irradiating a detection liquid with light. The detection liquid contains methyl salicylate. The method further includes converting scattered light from the detection liquid into an electric signal by using photoelectric conversion after irradiating the detection liquid with the light. The method further includes performing a particle measurement on the detection liquid by using the electric signal.

Disclosed are a femtosecond laser-based ultrasonic measuring apparatus for a 3D printing process, and a 3D printing system including the apparatus. The apparatus includes a femtosecond laser source for generating a femtosecond laser beam irradiated to inspect a state of a printing object formed by melting a base material by a printing laser beam irradiated from the laser source for 3D printing, a beam splitter for separating the femtosecond laser beam generated by the femtosecond laser source into a pump laser beam and a probe laser beam, an electric/acoustic optical modulator for modulating the pump laser beam, a time delay unit for delaying the probe laser beam, a photo detector for detecting the probe laser beam reflected by the printing object, and a lock-in amplifier for detect an amplitude and a phase of the output signal from the photo detector. The femtosecond laser source is disposed coaxially with a laser source for 3D printing.