The present disclosure concerns a method and apparatus for measuring a sensor (10) comprising multiple optical resonators (11, 12) optically connected to a single optical output interface (16). The optical resonators (11, 12) are interrogated with a light input signal (Si). A light output signal (So) is measured from the optic al output interface (16) to determine a combined spectral response (Sa) covering a wavelength range (W) including a plurality of resonance peaks (1,i, 2,j) for each of the optical resonators (11, 12). A Fourier transform spectrum (FT) of the combined spectral response (Sa) is calculated and a harmonic series of periodic peaks (n.Math.f1) is identified in the Fourier transform spectrum (FT). The harmonic series of periodic peaks is filtered to obtain a filtered Fourier transform spectrum (FT1) and a sensor signal is calculated (X1) based on the filtered Fourier transform spectrum (FT1).

An optical device including a waveguide microresonator, laid out to guide a light beam along a closed loop optical path; and at least one injection and/or extraction waveguide, optically coupled to the microresonator for injection and/or extraction of the light beam. The microresonator is composed of a plurality of elementary waveguides with a spacing between them, and located one after the other to form a loop-shaped layout. Among other things, the invention increases the sensitivity of the microresonator to the surrounding medium.

The present disclosure relates to a device for measuring an optical absorption property of a fluid as function of wavelength. The device comprises a broadband light source for emitting light, a plurality of integrated optical waveguides for guiding this light, and a light coupler for coupling the emitted light into the integrated optical waveguides such that the light coupled into each integrated optical waveguide has substantially the same spectral distribution. The device also comprises a microfluidic channel for containing the fluid, arranged such as to allow an interaction of the light propagating through each waveguide with the fluid in the microfluidic channel. Each integrated optical waveguide comprises an optical resonator for filtering the light guided by the waveguide according to a predetermined spectral component. The spectral component corresponding to each waveguide is substantially different from the spectral component corresponding to another of the waveguides.

Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.

A flexible waveguide structure including a waveguide on a flexible substrate, both having transparent windows in the mid-infrared range, may serve as a photonic chemical sensor for measuring characteristic absorptions of analytes brought in physical contact with the waveguide. Such a sensor may, in accordance with some embodiments, be formed by an aluminum-nitride waveguide on a borosilicate substrate.

Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.

A lab-on-a-chip system (100) comprises an optical detection waveguide (122) that has an at least partially periodic structure (123, 501, 502, 503, 504) that is configured to couple light (152) from surroundings of the optical detection waveguide (122) into the optical detection waveguide (122). The lab-on-a-chip system (100) furthermore also comprises a microfluidic network (212), wherein the microfluidic network (212) has multiple lines and at least one reaction chamber (211, 211-1, 211-2, 211-3).

The present disclosure describes a device for measuring an optical absorption property of a fluid as function of wavelength. The device comprises a broadband light source for emitting light, a plurality of integrated optical waveguides for guiding this light and a light coupler for coupling the emitted light into the integrated optical waveguides such that the light coupled into each integrated optical waveguide has substantially the same spectral distribution. The device also comprises a microfluidic channel for containing the fluid, arranged such as to allow an interaction of the light propagating through each waveguide with the fluid in the microfluidic channel, and a plurality of spectral analysis devices optically coupled to corresponding waveguidessuch as to receive the light after interaction with the fluid. The spectral analysis devices are adapted for generating a signal representative of a plurality of spectral components of the light.

Disclosed is a microfluidic detection device including a circuit substrate and a transparent substrate. The circuit substrate is provided with at least one first light-emitting device used to emit a detection beam, a photodetector used to receive the detection beam and send out a sensing signal, and a control circuit electrically connected to the first light-emitting device and the photodetector. The transparent substrate overlaps the circuit substrate and is provided with a microfluidic channel and a light guide structure. The light guide structure has a light incident surface disposed corresponding to the first light-emitting device and a light exiting surface disposed corresponding to the photodetector. The light guide structure extends from each of the light incident surface and the light exiting surface to the microfluidic channel and is adapted to transmit the detection beam into and out of the microfluidic channel.

A light guide device for conducting a light beam between a light source and a measuring unit for measuring a gas or substance concentration includes a light conductor and a holding apparatus. The conductor includes at least one coupling section, which faces, or can be arranged to be turned toward, the light source, for coupling the light beam, and a decoupling section, which faces, or can be arranged to be turned toward, the measuring unit, for decoupling the light beam. The conductor is configured to conduct the light beam between the coupling section and the decoupling section via total reflection on a boundary surface to a fluid or material that surrounds the conductor and has a smaller refractive index than the conductor. The holding apparatus is configured to hold the conductor in the fluid such that at least one primary portion of a surface of the conductor contacts the fluid.