A system, apparatus, and method for registering and interpreting the results of lateral flow assay determination by using electric, magnetic, and RF sensors incorporated within the test strip, attached to the inside of the enclosure for same and/or contained in a test fixture; instead of relying on optical inspection techniques. This method features high reliability, low cost, and ability for quantitative and dynamic measurements.

A significant enhancement of detection capabilities of the room temperature MPQ is seen using optical lithography-defined, ferromagnetic iron-nickel alloy microdisks. Irreversible transitions between strongly non-collinear (vortex) and a collinear single domain states, driven by an ac magnetic field, translate into a nonlinear magnetic response that enables ultrasensitive detection of material at relatively small magnetic fields.

A method and apparatus for the manipulation for an identification purpose of a microcarrier. The method comprising the steps of: (a) an identification purpose step of the microcarrier; and (b) a positioning and orientation step prior to or during the identification purpose step. The apparatus comprising means for identification purposes such as a microscope or labelling means such as a high spatial resolution light source, and means for the positioning and orientation of the microcarriers.

Embodiments are directed to a sensor having a first electrode, a second electrode and a detector region electrically coupled between the first electrode region and the second electrode region. The detector region includes a first layer having a topological insulator. The topological insulator includes a conducting path along a surface of the topological insulator, and the detector region further includes a second layer having a first insulating magnetic coupler, wherein a magnetic field applied to the detector region changes a resistance of the conducting path.

A method for detecting particles in a sample includes adding magnetic detection particles to the sample, the magnetic detection particles configured to bind to the particles for detection, and reading in a measurement signal from an interface to at least one magnetic field sensor. The measurement signal includes at least one acquired characteristic of a magnetic field extending at least through a partial quantity of the sample. The method further includes ascertaining a fluctuation intensity of the at least one characteristic of the magnetic field, the fluctuation intensity dependent on the detection particles. The method also further includes determining a state of binding of at least one detection particle as unbound or bound to a particle for detection based on the determined fluctuation intensity in order to detect the particles in the sample.

A magneto-optical bio-detection device including: a sample cell, a coil, a magnetic core, a light source and a light detection unit. The sample cell is filled with a solution containing a detection object and a magnetic biosensor capable of combining with the detection object to form a magnetic cluster. The coil is used for producing an oscillating magnetic field. The magnetic core has a guide portion, and an upper magnetic pole and a lower magnetic pole located at both ends of the guide portion; on a cross section orthogonal to the oscillating magnetic field, a cross-sectional area of the upper magnetic pole is less than a cross-sectional area of the guide portion. The light source is used for emitting light rays to penetrate the sample cell. The light detection unit is used for receiving the light rays that penetrated the sample cell to produce a detection signal.

Correlated double sampling (CDS) for magnetoresistive (MR) sensors is provided. Here the MR sensor output is sampled at two closely spaced times. The first sample is MR signal+baseline+noise and is sampled when the modulated magnetic field is non-zero. The second sample is baseline+noise only because it is sampled when the modulated magnetic field is zero. The difference between the first and second samples will have significantly reduced low frequency noise and baseline cancellation. Modulation of the electrical bias provided to the MR sensor can be used to provide a baseline signal for temperature compensation. In a second aspect, we provide MR sensor arrays having input and output multiplexing and demultiplexing for row and column line selection, in combination with a per-sensor switch to prevent noise accumulation and bandwidth reduction from idle MR sensors.

Disclosed is a magnetic sensor for measuring flux density. The sensor comprises at least one tunnelling magnetoresistor, supporting circuitry and an output for outputting a signal from the tunnelling magnetoresistor. In another aspect, there is also provided a sensor probe comprising at least one magnetic sensor. A magnetic probe system is also described, comprising the probe sensor and processing circuitry. Methods of processing the output signal from the magnetic sensor are also described. In one application, the system and method allow for detection of tissue such as lymph nodes that have taken up small quantities of magnetic particles upon injection of a magnetic tracer containing the magnetic particles into a patient, and can be used to identify such tissue that could be affected by certain forms of cancer.

Methods and compositions are provided for objectively characterizing a pathological lesion in a patient. The method comprises: introducing into the patient a contrast enhancing agent; subjecting the patient to magnetic resonance imaging to obtain an image; and applying a 3-D autocorrelation function to a subdomain of interest of the image to obtain at least one 3-D autocorrelation spectrum. The method may further comprise comparing the at least one 3-D autocorrelation spectrum to a pre-existing 3-D autocorrelation spectrum that is characteristic for the pathological lesion. In one example, the methods and compositions may be useful for identifying and objectively characterizing amyloid plaque deposits characteristic of Alzheimer's Disease.

Embodiments are directed to a sensor having a first electrode, a second electrode and a detector region electrically coupled between the first electrode region and the second electrode region. The detector region includes a first layer having a topological insulator. The topological insulator includes a conducting path along a surface of the topological insulator, and the detector region further includes a second layer having a first insulating magnetic coupler, wherein a magnetic field applied to the detector region changes a resistance of the conducting path.