A method of detecting a particle comprises magnetizing a particle using an AC magnetic field; generating an AC voltage in a sensing device having a conductive substantially 2-dimensional lattice structure from the magnetized particle; superimposing a DC magnetic field on the generated AC voltage in the sensing device; and measuring an AC Hall voltage at the sensing device.

This invention relates to methods for diagnosing cancer, e.g., cancer of epithelial origin, by detecting the presence of tumor cells in a sample, based (at least in some embodiments) on the quantification of levels of four biomarkers, MUC1, EGFR, EpCAM, and HER2. In some embodiments, the methods are performed using diagnostic magnetic resonance (DMR), e.g., with a portable relaxometer or MR imager.

A method of detecting a particle comprises magnetizing a particle using an AC magnetic field; generating an AC voltage in a sensing device having a conductive substantially 2-dimensional lattice structure from the magnetized particle; superimposing a DC magnetic field on the generated AC voltage in the sensing device; and measuring an AC Hall voltage at the sensing device.

According to one embodiment, a sample analyzer includes a detector, a first generator and a second generator. The detector detects a target substance bonded to a magnetic particle collected to a sensing area in the cartridge. The first generator applies a magnetic field for releasing the magnetic particles from the sensing area. The second generator includes a permanent magnet configured to generate a magnetic field for attracting the magnetic particles to the sensing area, a first soft magnetic material, and a second magnetic material. The second generator switches application and shut-off of a magnetic field by moving the permanent magnet relative to the first soft magnetic material and the second soft magnetic material.

A biomolecular sensor system includes an array of magnetoresistive nanosensors designed for sensing biomolecule-conjugated superparamagnetic nanoparticles. Materials and geometry of each sensor element are designed for optimized sensitivity. The system includes magnetic field generators to apply forces to superparamagnetic nanoparticles for 1) nanoparticle manipulation, 2) sensor magnetic biasing, 3) magnetic pull-off measurement for differentiation against non-specific association, and 4) removal of all particles from the sensor array surface.

The present disclosure is directed towards characterizing liquids through the use of magnetic discs that rotate in response to dynamic magnetic fields. In some embodiments, a light beam is transmitted into the liquid while the magnetic discs rotate, and one or more parameters a light beam signal associated with the transmitted light beam are identified. Various characteristics of the liquid may be detected based on the one or more parameters of the light beam signal.

The present invention relates to a method for calculating the change of signals starting from the originally detected temporal signals (_102 ), comprising the following steps: (a) eliminating the drift in the originally detected temporal signals with time to get .sub.i signals; (b) removing the xi signals existing outside the range of 80% to 120% of the averaged value of all the .sub.i signals to get residual signals as x .sub.2 signals; (c) dividing the .sub.2 signals into 14-100 sections; (d) finding the averaged value of the .sub.2 signals in each section to get .sub.3 signals; (e) optionally neglecting one or two of the first .sub.3 signals and selecting six to nine .sub.3 signals with the smallest value of standard deviation in initial sections, wherein the initial sections are the first one-fourth part to half part of all sections; (f) eliminating the drift in the selected .sub.3 signals of step (e) with time to get .sub.4 signals; (g) selecting six to nine .sub.3 signals with the smallest value of standard deviation in terminal sections, wherein the terminal sections are the last one-fourth part to half part of all sections; (h) eliminating the drift in the selected .sub.3 signals of step (g) with time to get .sub.5 signals; and (i) finding the difference between the mean values of the .sub.4 and .sub.5 signals.

A signal processing system used for GMR-based detection of a target analyte in a sample under test, comprising: a measurement circuit configuration unit configured to build a GMR sensor measurement circuit by routing in at least one GMR sensor, and to build a reference resistor measurement circuit by routing in at least one reference resistor; a magnetic field excitation unit configured to apply an AC magnetic field of frequency .sub.2 to the at least one GMR sensor; a carrier signal applying unit configured to apply a carrier signal of frequency .sub.1 to the GMR sensor measurement circuit, and apply carrier signals of frequency .sub.1, .sub.1+.sub.2, and .sub.1.sub.2 to the reference resistor measurement circuit; a measurement signal pick-up unit coupled to the measurement circuits, configured to collect reference resistor measurement signals from the reference resistor measurement circuit and GMR sensor measurement signals from the GMR sensor measurement circuit; and a phase sensitive solution unit coupled to the measurement signal pick-up unit, configured to analytically solve for resistance change of the at least one GMR sensor based on both the reference resistor measurement signals from the reference resistor measurement circuit and the GMR sensor measurement signals from the GMR sensor measurement circuit.

A method of sensing molecules using a detection device, the detection device comprising a plurality of magnetoresistive (MR) sensors and at least one fluidic channel, comprising adding a plurality of molecules to be detected to the at least one fluidic channel, wherein at least some of the plurality of molecules to be detected are coupled to respective magnetic nanoparticles (MNPs), detecting a characteristic of a magnetic noise of a first MR sensor of the plurality of MR sensors, wherein the characteristic of the magnetic noise is influenced by a presence of one or more MNPs in a vicinity of the first MR sensor, and determining, based on the detected characteristic, whether the first MR sensor detected the presence of one or more MNPs in the vicinity of the first MR sensor.

The present invention relates to methods and (bio)sensor systems. Herein, magnetic fields are applied in order to transport magnetic particles laterally over a sensor surface with analyte specific probes. The methods of the invention allow the specific binding of magnetic particles to the sensor surface, while aspecific and unbound particles are removed.