A delta-relaxation magnetic resonance imaging (DREMR) system is provided. The system includes a main field magnet and field shifting coils. A main magnetic field with a strength B0 can be generated using the main filed magnet and the strength B0 of the main magnetic field can be varied through the use of the field-shifting coils. The DREMR system can be used to perform signal acquisition based on a pulse sequence for acquiring at least one of T2*-weighted signals imaging; MR spectroscopy signals; saturation imaging signals and MR signals for fingerprinting. The MR signal acquisition can be augmented by varying the strength B0 of the main magnetic field for at least a portion of the pulse sequence used to acquire the MR signal.

A delta-relaxation magnetic resonance imaging (DREMR) system is provided. The system includes a main field magnet and field shifting coils. A main magnetic field with a strength B0 can be generated using the main filed magnet and the strength B0 of the main magnetic field can be varied through the use of the field-shifting coils. The DREMR system can be used to perform signal acquisition based on a pulse sequence for acquiring at least one of T2*-weighted signals imaging; MR spectroscopy signals; saturation imaging signals and MR signals for fingerprinting. The MR signal acquisition can be augmented by varying the strength B0 of the main magnetic field for at least a portion of the pulse sequence used to acquire the MR signal.

A method for detecting tumor tissue boundaries or a tumor stromal cell distribution range, more specifically, a diagnostic or non-diagnostic method for determining the boundaries of a tumor tissue; the boundaries of the tumor tissue are determined by means of determining the boundaries of the tumor stromal cells in the tumor tissue. The present method can more accurately determine the boundaries of tumor tissue, which serves to more accurately instruct the treatment of tumors, especially with respect to surgical treatment.

A method for detecting tumor tissue boundaries or a tumor stromal cell distribution range, more specifically, a diagnostic or non-diagnostic method for determining the boundaries of a tumor tissue; the boundaries of the tumor tissue are determined by means of determining the boundaries of the tumor stromal cells in the tumor tissue. The present method can more accurately determine the boundaries of tumor tissue, which serves to more accurately instruct the treatment of tumors, especially with respect to surgical treatment.

According to an example aspect of the present invention, there is provided generating, Low-Field-Magnetic Resonance Imaging, LF-MRI, or Ultra-Low-Field Magnetic Resonance Imaging, ULF-MRI, data with respect to an image frame, determining a sensorwise agreement of the data with determined sensitivity profiles, and determining a mapping between the image frame and a sensor frame, such that the sensorwise agreement has been fulfilled.

Disclosed herein is a method of conducting direct detection .sup.1H solid state NMR (“ssNMR”) on a macromolecule-containing solid state formulation. The method includes conducting a .sup.1H spin-lattice relaxation time (“T.sub.1”) experiment on the solid state formulation at various temperatures to generate a T.sub.1 value at each temperature, converting the T.sub.1 values to .sup.1H spin-lattice relaxation rate (“R.sub.1”), and plotting R.sub.1 versus temperature to generate a relaxation rate curve for the solid state formulation. The relaxation rate curve can be analyzed to determine the molecular mobility of the macromolecule in the solid state formulation, the degree of aggregation in the solid state formulation, and/or the stability of the solid state formulation.

The current invention is based, at least in part, on the finding that the transverse nuclear magnetic spin relaxation time T2 and the transverse nuclear magnetic spin relaxation rate R2, respectively, of protons of water molecules in an aqueous solution comprising viral particles depends on the loading status (full vs. empty) of the viral particle. Thus, one aspect of the current invention is a method for determining the ratio of loaded viral particles to empty viral particles in a sample, comprising the steps of determining a nuclear magnetic resonance (NMR) parameter related to the protons of the water molecules present in an aqueous solution comprising a mixture of loaded and empty viral particles by applying an NMR measurement to the solution, and determining the ratio of loaded viral particles to empty viral particles with the NMR parameter determined in the previous step based on a calibration function.

The invention relates to a device for magnetic measurements and/or magnetic imaging such as an MRI device or a hybrid MEG-MRI device. The device comprises an array of one or more detectors for the magnetic signal and one or more coils for producing preparatory magnetic field pulses. The device further comprises means to drive current pulses through the said coils, wherein at least one of the coils comprises material that is Type-II superconducting at the operating temperature. The device is configured to cancel out at least part of the field generated by the remanent magnetization after a current pulse by the shape of the current pulse and/or the geometrically balanced design of the coil.

Disclosed is a quantitative susceptibility mapping image processing method using an unsupervised learning-based neural network and an apparatus therefor. The quantitative susceptibility mapping image processing method includes receiving a phase image and a magnitude image for reconstructing the quantitative susceptibility mapping image, and reconstructing the quantitative susceptibility mapping image corresponding to the received phase image and the received magnitude image using an unsupervised learning-based neural network, and the neural network may be generated based on an optimal transport theory.

An apparatus for providing a B.sub.0 magnetic field for a magnetic resonance imaging system. The apparatus includes at least one permanent B.sub.0 magnet to contribute a magnetic field to the Bo magnetic field for the MRI system and a ferromagnetic frame configured to capture and direct at least some of the magnetic field generated by the B.sub.0 magnet. The ferromagnetic frame includes a first post having a first end and a second end, a first multi-pronged member coupled to the first end, and a second multi-pronged member coupled to the second end, wherein the first and second multi-pronged members support the at least one permanent B.sub.0 magnet.