A coupling device is provided for coupling microwave radiation from a first microwave structure, in particular a microwave waveguide, into a second microwave structure, in particular a microwave resonant cavity, wherein the first and second microwave structures share a common wall, through an iris opening in said wall in front of which the coupling device is positioned on the side of the first microwave structure, in particular wherein the coupling device is of a basically cylindrical shape, characterized in that the coupling device comprises N electrically conducting conductor loops, with N≥3, preferably 3≤N≤20, that the conductor loops are arranged coaxially in an array along a z-axis, and that axially neighboring conductor loops are separated by a dielectric. The inventive coupling device allows for a larger coupling coefficient, and in particular allows for a larger dynamic range.

The invention provides methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO2 to a subject to reach a predetermined PaCO2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. The invention also provides methods for increasing sensitivity and specificity of BOLD MRI.

The invention provides methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO2 to a subject to reach a predetermined PaCO2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. The invention also provides methods for increasing sensitivity and specificity of BOLD MRI.

An apparatus for increasing efficiency in the transmission phase and sensitivity in the reception phase, in specific regions of space, of magnetic resonance imaging technique by using at least one metamaterial or dielectric material is provided. Placing the metamaterial or dielectric material in a suitable geometry, in the space delimited by an RF coil and a sample, allows using the surface plasmonic resonances or equivalent dielectric resonances, induced in the metamaterial or dielectric material by the RF coil, to amplify the intensity of the magnetic field in the spatial region of the sample, improving the intensity of the signal transmission and/or the sensitivity of detection. The metamaterial or dielectric material is positioned outside the RF coil to maximize the amplification effect.

An apparatus for increasing efficiency in the transmission phase and sensitivity in the reception phase, in specific regions of space, of magnetic resonance imaging technique by using at least one metamaterial or dielectric material is provided. Placing the metamaterial or dielectric material in a suitable geometry, in the space delimited by an RF coil and a sample, allows using the surface plasmonic resonances or equivalent dielectric resonances, induced in the metamaterial or dielectric material by the RF coil, to amplify the intensity of the magnetic field in the spatial region of the sample, improving the intensity of the signal transmission and/or the sensitivity of detection. The metamaterial or dielectric material is positioned outside the RF coil to maximize the amplification effect.

A fibrosis measurement device that measures fibrosis of a biological tissue non-invasively includes: a sound wave emitter that performs scanning over a surface of a biological tissue as a measurement object to emit sound waves; an electromagnetic wave receiver that receives an electromagnetic wave generated at each location of a biological tissue irradiated with sound waves; a signal extractor that extracts a signal indicating physical property, based on at least one selected from a group including the amplitude, phase, and frequency of an electromagnetic wave received by the electromagnetic wave receiver; an imaging unit that images signals extracted by the signal extractor; and an area comparison unit that compares the area of a portion of the two-dimensional image in which signals indicating a property are displayed, with an area corresponding to a preset threshold of the strength of the signals.

An electron intrinsic spin analyzer measures the quantum states from a free-electron beam wherein the intrinsic-spin property of the electron's beam interacted with an inhomogeneous magnetic field. The generated beam from a hot tungsten wire paralleled after the initial deflecting and absorbing process by metal grids, and the paralleled beam travels without electrical or magnetic focusing through on a glass lamp. A graphite cover on both sides of the glass lamp and a gitter composed of cesium dioxide and barium absorbed other types of particles such as ions and atoms to do not hit the fluorescent plate. The free-electron beam interacted with independent assemblies of magnets on the moveable chassis, which produced from a homogeneous or inhomogeneous magnetic field and used for checking the rightness of the measured physics effects. The optically and electrically detections collected the data with a Langmuir probe and a charge-coupled device camera.

An electron intrinsic spin analyzer measures the quantum states from a free-electron beam wherein the intrinsic-spin property of the electron's beam interacted with an inhomogeneous magnetic field. The generated beam from a hot tungsten wire paralleled after the initial deflecting and absorbing process by metal grids, and the paralleled beam travels without electrical or magnetic focusing through on a glass lamp. A graphite cover on both sides of the glass lamp and a gitter composed of cesium dioxide and barium absorbed other types of particles such as ions and atoms to do not hit the fluorescent plate. The free-electron beam interacted with independent assemblies of magnets on the moveable chassis, which produced from a homogeneous or inhomogeneous magnetic field and used for checking the rightness of the measured physics effects. The optically and electrically detections collected the data with a Langmuir probe and a charge-coupled device camera.

By producing the proper wave interference using superimposed waves that overlap with the proper time-phase relationship (called “Time-Correlated Standing-wave Interference”), wave energy is amplified (by “Coherent Intensity Amplification”) and teleported to precise locations. For instance, in one application, energy is teleported to one or more areas within a living body for such therapeutic applications as destroying cancer cells or plaques within arteries. A system implementing this technique creates amplified constructive interference at one or more selected disease locations, while producing destructive interference at surrounding locations. In this application example, the technique allows energy to be “teleported” to tumor cells, plaques, or other diseased cells, for instance, to destroy them, while surrounding healthy cells receive virtually no energy, obviating collateral damage from the treatment. The same method can be used to diagnose disease by detecting energy teleported to different locations.

A magnetic field causing a difference of energy level between different spin states in the sample can be applied, a spin transition in the material can be triggered by exposing the sample to electromagnetic radiation of an energy level corresponding to the difference in energy level between the different spin states, a sensing surface of a superconducting element can be exposed to a magnetic field of the spins in the sample, the spin transition can cause, via kinetic inductance, a change in electromagnetic waves carried by the superconducting element which can be detected. A magnetic field component normal to the sensing surface, below a certain magnetic field threshold, can be applied to favor sensitivity.