A coded mask apparatus is provided for gamma rays. The apparatus uses nested masks, at least one of which rotates relative to the other.

A coded mask apparatus is provided for gamma rays. The apparatus uses nested masks, at least one of which rotates relative to the other.

A radioisotope generator that releases a daughter radioisotope from radioactive decay of a corresponding parent isotope, such as a .sup.82Sr/.sup.82Rb radioisotope generator or .sup.68Ge/.sup.68Ga radioisotope generator, may be used to generate radioisotopes for medical imaging applications. In some examples, a gamma ray detector is positioned to detect gamma rays emanating from radioactive eluate flowing from the generator. Based on the detected gamma rays, an activity of the daughter radioisotope in the eluate and an activity of the parent radioisotope in the eluate may be determined. Depending on the application, the activity of the daughter radioisotope and the activity of the parent radioisotope may be determined in substantially real time, e.g., so that the eluate can be diverted from patient dosing based on determined activity information for the eluate.

A radioisotope generator that releases a daughter radioisotope from radioactive decay of a corresponding parent isotope, such as a .sup.82Sr/.sup.82Rb radioisotope generator or .sup.68Ge/.sup.68Ga radioisotope generator, may be used to generate radioisotopes for medical imaging applications. In some examples, a gamma ray detector is positioned to detect gamma rays emanating from radioactive eluate flowing from the generator. Based on the detected gamma rays, an activity of the daughter radioisotope in the eluate and an activity of the parent radioisotope in the eluate may be determined. Depending on the application, the activity of the daughter radioisotope and the activity of the parent radioisotope may be determined in substantially real time, e.g., so that the eluate can be diverted from patient dosing based on determined activity information for the eluate.

Focusing on a gamma ray detection phenomenon (event) in which a gamma ray from a gamma ray source is Compton scattered at a first-stage detector, the gamma ray is photoelectrically absorbed at a second-stage detector, the spatial distribution of the gamma ray source is imaged within a predetermined image space on the basis of measurement data for the interaction of the detectors and gamma rays. At this time, a probability parameter (v.sub.ij) indicating the probability that Compton-scattered gamma ray arrived from within the image space and a detection sensitivity parameter (s.sub.ij) indicating gamma ray detection sensitivity are set for each event and each pixel on the basis of the measurement data for each event, and these parameters are used to determine the pixel values (λ.sub.j) for each pixel.

Focusing on a gamma ray detection phenomenon (event) in which a gamma ray from a gamma ray source is Compton scattered at a first-stage detector, the gamma ray is photoelectrically absorbed at a second-stage detector, the spatial distribution of the gamma ray source is imaged within a predetermined image space on the basis of measurement data for the interaction of the detectors and gamma rays. At this time, a probability parameter (v.sub.ij) indicating the probability that Compton-scattered gamma ray arrived from within the image space and a detection sensitivity parameter (s.sub.ij) indicating gamma ray detection sensitivity are set for each event and each pixel on the basis of the measurement data for each event, and these parameters are used to determine the pixel values (λ.sub.j) for each pixel.

A bioimage acquiring device includes a first conversion unit that performs a first conversion process wherein a negative bioimage is converted using a first converter so as to acquire a converted bioimage which is the result of the conversion, and a classifying unit that performs a first classifying process wherein a determination is made as to whether the converted bioimage is a positive bioimage or a negative bioimage, using a classifier for determining whether an image is a negative bioimage or a positive bioimage, wherein the first conversion unit performs a learning process using the determination result obtained by the classifying unit and the converted bioimage, performs an update process for updating the first converter, and receives a new negative bioimage, and the first conversion unit converts the new negative bioimage using the updated first converter to acquire a converted bioimage which is the result of the conversion.

A bioimage acquiring device includes a first conversion unit that performs a first conversion process wherein a negative bioimage is converted using a first converter so as to acquire a converted bioimage which is the result of the conversion, and a classifying unit that performs a first classifying process wherein a determination is made as to whether the converted bioimage is a positive bioimage or a negative bioimage, using a classifier for determining whether an image is a negative bioimage or a positive bioimage, wherein the first conversion unit performs a learning process using the determination result obtained by the classifying unit and the converted bioimage, performs an update process for updating the first converter, and receives a new negative bioimage, and the first conversion unit converts the new negative bioimage using the updated first converter to acquire a converted bioimage which is the result of the conversion.

The purpose of the present invention is to provide a cyclic peptide having any unit structure selected from the structures represented by the following formula (1):

—X.sup.1—X.sup.2—X.sup.3—X.sup.4—X.sup.5—  (1) (in the formula (1), X.sup.1 is I, V or L, or an N-alkylamino acid thereof, X.sup.2 is S or T, or an N-alkylamino acid thereof, X.sup.3 is K or an N-alkylamino acid thereof, X.sup.4 is W or an N-alkylamino acid thereof, and X.sup.5 is W, Y, or H, or K or an N-alkylamino acid thereof), or a pharmaceutically acceptable salt of the cyclic peptide.

Apparatus, techniques and systems are described for facilitating identification of a target area during a probe-guided radio-localization surgical procedure. The described apparatus, techniques and systems can be used to implement a nuclear-uptake mode controller integrated into a probe to allow a user to instantly switch between multiple nuclear-uptake modes directly from the probe hand-piece. For example, a nuclear-uptake mode controller integrated into the probe can be used to instantly switch between a high-sensitivity nuclear-up-take mode and a high-resolution nuclear-uptake mode to effectively identify the target area in the presence of interfering nuclear signals by better matching the probe's nuclear detection parameters to a search task for that target area.