Various embodiments of a device for in-vivo measurements radiopharmaceuticals used for diagnosis and monitoring of radiotherapy are presented. In some embodiments, the present disclosure relates to a device having a cannula that may include a measurement chamber, a radiation detector and a delivery lumen, wherein the device may be used to both deliver material to the patient (e.g., radiotracers used in radiopharmaceuticals) and measure levels and concentrations of radioactive material in, for example, the patient's blood both during and after administration of the radioactive material. In some embodiments, particles emitted by the radioactive material interact with a scintillation material, resulting in the release of light that may be transmitted, via the scintillation material and/or fiber optic material, to an optical detectors or processor for processing. In some embodiments, particle absorbing materials may be used to limit measurements to materials within the measurement chamber or other area of interest.

Uptake of hypoxia-sensitive PET tracers is dependent on tissue transport properties, specifically, distribution volume. Variability in tissue transport properties reduces the sensitivity of static PET imaging to hypoxia. When tissue transport (v.sub.d) effects are substantial, correlations between the two methods of determining hypoxic fractions are greatly reduced—that is, trapping rates k.sub.3 are only modestly correlated with tumour-to-blood ratio (TBR). In other words, the usefulness of dynamic- and static-PET based hypoxia surrogates, trapping rate k.sub.3 and TBR, in determining hypoxic fractions is reduced in regions where diffusive equilibrium is achieved slowly. A process is provided for quantifying hypoxic fractions using a novel biomarker for hypoxia, hypoxia-sensitive tracer binding rate k.sub.b, based on PET imaging data. The same formalism can be applied to model the kinetics of non-binding CT and MT contrast agents, giving histopathological information about the imaged tissue.

A system (PP) and related methods for supporting nuclear imaging such as PET or other. The system comprises an input interface (IN) for receiving event data that represents an interaction event of gamma-radiation with a pixelated scintillator (SC) of a nuclear imaging apparatus (NIA). A pre-trained machine learning component (MLC) estimates a point spread function, PSF, for the said event. An output interface (OUT) outputs a representation of the PSF. The PSF may be used in emission image reconstruction for improved spatial resolution.

A system (PP) and related methods for supporting nuclear imaging such as PET or other. The system comprises an input interface (IN) for receiving event data that represents an interaction event of gamma-radiation with a pixelated scintillator (SC) of a nuclear imaging apparatus (NIA). A pre-trained machine learning component (MLC) estimates a point spread function, PSF, for the said event. An output interface (OUT) outputs a representation of the PSF. The PSF may be used in emission image reconstruction for improved spatial resolution.

A list mode image reconstruction method includes a step of dividing list mode data into a plurality of subsets and a step of acquiring a subset balance coefficient based on the number of events in the plurality of subsets.

A list mode image reconstruction method includes a step of dividing list mode data into a plurality of subsets and a step of acquiring a subset balance coefficient based on the number of events in the plurality of subsets.

A document creation support apparatus includes at least one processor, in which the processor is configured to derive properties for each of a plurality of predetermined property items in a structure of interest included in an image, generate a plurality of sentences describing the properties specified for at least one of the plurality of property items, and display each of the plurality of sentences, and display a described item, which is a property item of a property that is described in at least one of the plurality of sentences among the plurality of property items, on a display screen in an identifiable manner.

The present disclosure may provide a detector module of an imaging apparatus. The detector module may include a detector assembly configured to detect a signal associated with an object; a cover assembly configured to accommodate the detector assembly; and at least one cooling assembly operably coupled to the cover assembly. The at least one cooling assembly may be configured to cool the detector assembly by providing a cooling medium to the cover assembly.

A phantom, phantom system, and method of phantom identification include a first material that forms a phantom. A phantom identifier includes at least one unit marker. The at least one unit marker identifies a physical characteristic of the phantom. In a method of phantom identification, an image of the phantom is obtained that includes the phantom identifier. The at least one unit marker is identified, the at least one unit marker encodes a value representative of a physical characteristic of the phantom.

A phantom, phantom system, and method of phantom identification include a first material that forms a phantom. A phantom identifier includes at least one unit marker. The at least one unit marker identifies a physical characteristic of the phantom. In a method of phantom identification, an image of the phantom is obtained that includes the phantom identifier. The at least one unit marker is identified, the at least one unit marker encodes a value representative of a physical characteristic of the phantom.