Diffractive optical elements and methods for their fabrication are disclosed. In one aspect, a diffractive optical element is disclosed, which comprises a polymeric substrate substantially transparent to at least one electromagnetic radiation wavelength, and a plurality of metallic inclusions distributed in said polymeric substrate according to a predefined pattern such that said inclusions can collectively diffract at least a portion of incident radiation having said at least one radiation wavelength.

A miniaturized microscope having a tunable focal length provides for fluorescence measurements at an adjustable focus, providing for autofocus and/or depth adjustment of an image measurement without altering or adjusting a probe implanted in a sample and while providing collimated illumination of an area within the sample. The microscope includes an objective lens having a fixed position with respect to a second connector for receiving light returning from the sample and focusing it on an image sensor within the microscope that generates an image output, a beamsplitter for separating light returning from the sample, and an electrically-tunable lens positioned between the objective lens and the image sensor for adjusting an optical path length from the optical interface to the image sensor. The illumination is focused at or near a back focal plane of the objective lens to the sample, providing collimated or quasi-collimated illumination on or within the sample.

It is possible to observe imaging subjects, such as cells or the like, without causing an increase in the apparatus size. Provided is an observation apparatus including: a flat-plate-like stage formed of an optically transparent material on which a container accommodating a sample is placed; a deflecting member that is disposed below the stage and that deflects light coming from the sample on the stage into a substantially horizontal direction; an objective lens that collects the light deflected by the deflecting member; and an image-acquisition device that captures the light collected by the objective lens.

A lightweight 3D stereoscopic surgical microscope has a body, a robot set, an image set, and an operating set. The body has a wheel seat, a housing mounted on the wheel seat, and a host computer mounted in the housing. The robot set is connected to the body and has a base mounted on the housing, a transversal lever mounted on the base, a lifting arm connected to the transversal lever, and a rotating arm connected to the lifting arm. The image set is connected to the robot set and has an outer casing connected to the rotating arm, at least one objective lens mounted in the outer casing, a main display screen mounted on the outer casing, an auxiliary display screen mounted beside the body. The operating set is connected to the robot set, is connected to the body and the image set and has two operating bars.

An interface facility has a first facility element connected to an ocular, a device case configured to connect to a smart device, a second facility element connected to the device case, the first and second facility elements being configured to connect to each other in a connected condition and to detach from each other, the first facility element being registered with a first optical axis associated with the ocular, the second facility element being registered with a second optical axis associated with the camera, the first and second optical axes being registered with each other when the first and second facility elements are in the connected condition, such that the camera records images generated by the ocular. The first and second facility elements may comprise a bayonet mount.

An imaging sensing system containing: i) a fibre optic plate (FOP) having a proximal end, a distal end and a body situated between the proximal and distal ends; ii) at least one illumination component, and ii) an image sensor proximate the FOP.

A large-field-of-view, high-throughput and high-resolution pathological section analyzer includes an image collector for collecting a set of computing microscopic images of a pathological section sample; a data preprocessing circuit for iteratively updating the set of computing microscopic images by a multi-height phase recovery algorithm to obtain a low-resolution reconstructed image; an image super-resolution circuit for super-resolving the low-resolution reconstructed image according to a pre-trained super-resolution model to obtain a high-resolution reconstructed image; and an image analysis circuit for automatically analyzing the high-resolution reconstructed image according to different tasks, and specifically selecting different analysis models according to the different tasks to obtain corresponding auxiliary diagnosis results. Imaging visual field of the pathological section analyzer is hundreds of times that of the traditional optical microscope, a deep learning network is adopted to analyze pathological conditions of unstained pathological sections, so that the analysis process of pathological sections is simplified.

Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm.sup.2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 μm resolution for an image of the field of view.

A scanner for scanning a QA test slide as part of a stain QA method, and method of using the scanner are described. The scanner comprises a housing defining an interior of the scanner, a slide holder within the housing and configured to receive a QA test slide, a digital camera within the housing and arranged to capture an image of the QA test slide when located in the slide holder, and a light source within the housing and arranged to illuminate both a rear side and a front side of the QA test slide when located in the slide holder.

Embodiments disclose a device for testing biological specimen. The device includes a sample carrier and a detachable cover. The sample carrier includes a specimen holding area. The detachable cover is placed on top of the specimen holding area. The detachable cover includes a magnifying component configured to align with the specimen holding area. The focal length of the magnifying component is from 0.1 mm to 8.5 mm. The magnifying component has a linear magnification ratio of at least 1.