A microscope comprises a housing having a receiving portion for receiving at least one biological sample, an optics module comprising several objectives and an illumination system for illuminating at least one biological sample and/or an acquiring system for acquiring light coming from at least one biological sample, wherein the optics module is arranged in an inner space of the housing. The microscope is characterized in that the microscope comprises a replacement system for replacing an objective by one of the other objectives wherein the replacement system is configured to replace the objective by means of moving the optics module relative to the housing and/or by means of moving the housing relative to the optics module.

It is possible to observe imaging subjects, such as cells or the like, without causing an increase in the apparatus size. Provided is an observation apparatus including: a flat-plate-like stage formed of an optically transparent material on which a container accommodating a sample is placed; a deflecting member that is disposed below the stage and that deflects light coming from the sample on the stage into a substantially horizontal direction; an objective lens that collects the light deflected by the deflecting member; and an image-acquisition device that captures the light collected by the objective lens.

A system having a macroscopic imager, a microscopic imager, and a stage for moving a substrate supporting ex-vivo tissue with respect to each of the imagers to enable the macroscopic imager to capture macroscopic images, and the microscopic imager to capture optically formed sectional microscopic images on or within the tissue, when presented to the tissue, via the optically transparent material of the substrate. A computer system controls movement of the stage, and receives the macroscopic and microscopic images. A display is provided for displaying the macroscopic and microscopic images when received by the computer system. The tissue is verified as being in an orientation at least substantially flush against the upper surface of the substrate by being in focus in displayed macroscopic images prior to imaging by the microscopic imager, and if needed, any portion of the tissue unfocused is manually positioned until desired tissue orientation is achieved.

An ergonomic digital imaging system obviates the need for, and replaces, the standard microscope with binoculars for viewing images, thereby freeing the user from using his or her hands to manipulate images seen through the binoculars of the microscope, whereby the user can use his or her hands for other tasks, such as dental or other surgery, from a position away from the exhaled breath of the patient being treated. The images are maintained focused, no matter how close or far the viewer is to the viewing display screen. The system is collapsible and portable, so that specialists can take the system from office to office, a plug and play work environment. The extended maneuverability of the camera head results in simple and fast patient positioning, and the camera and display module adjust for any comfortable sit or stand ergonomics of the practitioner.

In some implementations, an optical component of a microscope may capture an image of a profile of a ferrule and a connector of an optical fiber based on the ferrule being received by a first opening of a first connector adapter of the microscope. A mechanical axis of the ferrule may be orthogonal to an optical path from a camera of the microscope to the ferrule when the ferrule is received by the first opening. One or more processors associated with the microscope may process the image to determine a measurement of a chamfer of the ferrule. The optical component may capture an image of an endface of the ferrule based on the ferrule being received by a second opening of a second connector adapter. The mechanical axis of the ferrule may be axially aligned with the optical path when the ferrule is received by the second opening.

An imaging sensing system containing: i) a fibre optic plate (FOP) having a proximal end, a distal end and a body situated between the proximal and distal ends; ii) at least one illumination component, and ii) an image sensor proximate the FOP.

Methods and systems are provided for synchronizing image capture at a multi-detector imaging system. In one example, a method includes coordinating cycling of each microscope assembly of the multi-detector imaging system through a selection of illumination channels, each microscope assembly configured to obtain an image of a portion of one of more than one microplate wells simultaneously, to generate complete images of the more than one microplate wells concurrently.

A image acquisition device including a connection section having an opening; an optical-path switching unit that changes an optical path of light entering from the opening; and two image acquisition elements. The optical-path switching unit includes two parallel reflective surfaces disposed with a distance therebetween and is swivelable about a swivel axis such that the reflective surface is insertable into and withdrawable from an incident optical axis. The first image acquisition element is disposed on the incident optical axis at the opposite side of the opening with the optical-path switching unit interposed therebetween. The second image acquisition element is disposed at a position where the second image acquisition element acquires an image of the light that has been deflected by the two reflective surfaces and is tilted about central axes of the two image acquisition elements relative to a straight line extending orthogonally to the central axes.

The present invention relates to a device and a method for microscopy (100) of a plurality of samples (102), wherein the device comprises:—a first optical detector (106, 108), which is designed to consecutively adopt a plurality of measuring positions and to detect first image data (200) of a sample (104) with a first spatial resolution at each measuring position;—an image data analyser device which is designed to determine for each sample (202) a region (204) of the sample to be examined represented within the first image data (200) in each case;—a second optical detector (110, 112), which is coupled to the first optical detector (106, 108) in such a manner that the second optical detector (110, 112) tracks the first optical detector (106, 108) and therefore the second optical detector (110, 112) adopts measuring positions which the first optical detector (106, 108) had previously adopted. The second optical detector (110, 112) is designed to detect for each sample (202) respective second image data (300) from the region (204) to be examined in the sample (202) concerned, with a spatial resolution that is higher than the first spatial resolution.

A microscope system comprises a microscope body, an imaging unit connected to the microscope body and including an image sensor for capturing a microscopic image, and an XY stage configured to place a slide and move in an X direction and a Y direction. The microscope system changes an arrangement of the image sensor with respect to the microscope body so as to cause a direction defined by a pixel arrangement of the image sensor to align with one of the X direction and the Y direction of the XY stage.