Systems based on atom and atom-like quantum emitters are promising platforms for quantum sensing, computing, and communications. State-of-the-art lasers and optical microscopy enable high-fidelity quantum control of the atomic quantum bits (qubits). However, it is challenging to scale up such individual quantum control to hundreds or thousands of atomic quantum nodes for implementing useful and practical quantum algorithms. Here, we introduce methods and systems to holographically implement large-scale quantum circuits that individually address atomic quantum nodes for various applications. These methods enable implementation of quantum circuits over large 2D and 3D arrays of atomic qubits at rates of thousands to millions of quantum circuit layers per second. The quantum circuit layers are encoded in multiplexed holograms displayed on a slow SLM and retrieved by fast interrogation to produce spatial distributions that operate on the qubit array. This technology can also be used for optically addressing objects such as biological cells and on-chip photonic components for optical tweezers, opto-genetics, optical computing, and optical neural networks.

Navigation applications may utilize various input data to determine various navigation routes. One example method of operating may include providing at least one navigation instruction to a navigation device via a navigation application, detecting the at least one instruction via a detection application, obtaining an image of a physical object, performing a holo-acoustic object manipulation of the physical object, and providing a visual display of the holo-acoustic manipulation as an additional navigation instruction.

Apparatus and methods for 3D-Scanless Holographic Optogenetics with Temporal focusing (3D-SHOT), which allows precise, simultaneous photo-activation of arbitrary sets of neurons anywhere within the addressable volume of the microscope. Soma-targeted (ST) optogenetic tools, ST-ChroME and IRES-ST-eGtACR 1, optimized for multiphoton activation and suppression are also provided. The methods use point-cloud holography to place multiple copies of a temporally focused disc matching the dimensions of a designated neuron's cell body. Experiments in cultured cells, brain slices, and in living mice demonstrate single-neuron spatial resolution even when optically targeting randomly distributed groups of neurons in 3D.

An example system includes a master oscillator that provides a master oscillator beam, a first fiber beam splitter that splits the master oscillator beam into a first branch and a second branch, a second fiber beam splitter that splits the first branch into an imaging branch and an amplified characteristic branch, and a compensation branch mixer that mixes the second branch and the amplified characteristic branch into a compensation branch. The example system includes transmission optics that direct the imaging branch to a target location, an imaging mixer that mixes the compensation branch and a reflected image from the target location into an imaging signal, and an acquisition device that receives the imaging signal as a final image. An example system optionally includes a mode matching lens that applies a selected wavefront characteristic to the compensation branch.

An optically trapped atom transfer tweezer includes an optical modulator which modulates incident light and generates a first hologram; a first lens which images the first hologram on an intermediate image plane and generates a first holographic image having any potential shape; a second lens which re-images the first holographic image on an entrance pupil of a third lens; the third lens which re-images a second hologram generated by the re-imaging of the second lens on a plane where an optically trapped atom array exists; a photographing device which captures optically trapped cold atoms from a second holographic image generated on the plane where an optically trapped atom array exists; and a controller which controls the optical modulator to adjust the second holographic image on the basis of the optically trapped atom image captured by the photographing device such that the optically trapped atom array is transferred to any spatial position.

Navigation applications may utilize various input data to offer route information and other suggested information. One example method may include initiating a navigation application on a first user device, identifying at least one destination of the navigation application, notifying a remote server of the at least one destination, receiving a first query from a second user device inquiring about the at least one destination, and transmitting a response comprising an identification of a first user profile associated with the first user device to the second user device.

Navigation applications may utilize various input data to determine various navigation routes. One example method of operating may include providing at least one navigation instruction to a navigation device via a navigation application, detecting the at least one instruction via a detection application, obtaining an image of a physical object, performing a holo-acoustic object manipulation of the physical object, and providing a visual display of the holo-acoustic manipulation as an additional navigation instruction.

Apparatus and methods for 3D-Scanless Holographic Optogenetics with Temporal focusing (3D-SHOT), which allows precise, simultaneous photo-activation of arbitrary sets of neurons anywhere within the addressable volume of the microscope. Soma-targeted (ST) optogenetic tools, ST-ChroME and IRES-ST-eGtACR 1, optimized for multiphoton activation and suppression are also provided. The methods use point-cloud holography to place multiple copies of a temporally focused disc matching the dimensions of a designated neuron's cell body. Experiments in cultured cells, brain slices, and in living mice demonstrate single-neuron spatial resolution even when optically targeting randomly distributed groups of neurons in 3D.

Navigation applications may utilize various input data to determine various navigation routes. One example method of operating may include providing at least one navigation instruction to a navigation device via a navigation application, detecting the at least one instruction via a detection application, obtaining an image of a physical object, performing a holo-acoustic object manipulation of the physical object, and providing a visual display of the holo-acoustic manipulation as an additional navigation instruction.

The invention, provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage,