Example embodiments provide digital holographic techniques and associated systems for imaging through scattering media in a strictly one-sided observation in which the observer (e.g. the controller of the camera) has no access to the object plane nor does the observer introduce a fluorescing agent to the object plane. An example imaging system comprises a laser source, a digital sensor array, and a processing system. The processing system transmits light from the laser source to a target object; detects interference formed on the digital sensor array by a reference beam from the transmitted light and reflected light from the target object, the reflected light either travelling through or being reflected by a scattering medium located between the target object and the digital sensor array; jointly estimating, based on the detected interference, parameters defining the scattering behavior of the particular scattering medium and an image of the target object; and outputting the jointly estimated scattering parameters and an image of the target object.

The present disclosure discloses an imaging system, method, and apparatus for identifying information of a hidden object. A light source generates a first beam of narrow-band light and a second beam of narrow-band light that has temporal fluctuations correlated with the first beam. The first beam is directed towards a first scattering surface and the second beam is directed towards a second scattering surface. The first scattering surface scatters the first beam to a scattered light that illuminates a hidden object, the hidden object reflects at least a portion of the scattered light towards the second scattering surface, the reflected light interferes with the second beam and produces an interference pattern on the second scattering surface. An image sensor detects irradiance of the interference pattern on the second scattering surface. An image processor calculates a complex-valued light field that represents information of the hidden object based on the detected irradiance of the interference pattern on the second scattering surface.

An infrared image is captured while an infrared reference wavefront and an infrared imaging signal are incident on an image pixel array. A frequency domain infrared image is generated by performing a transform operation on the infrared image. A filtered frequency domain infrared image is generated by applying a mask to the frequency domain infrared image to isolate a frequency representing the interference between the infrared reference beam and the incoming infrared image signal. Intensity data is generated from the filtered frequency domain infrared image. The intensity data is incorporated as a voxel value in a composite image.

An imaging device includes an image pixel array and a display pixel array. The image pixel array is configured to capture an infrared image of an interference between an infrared imaging signal and an infrared reference wavefront. The display pixel array is configured to generate an infrared holographic imaging signal according to a holographic pattern driven onto the display pixels. The holographic pattern is derived from the infrared image captured by the image pixel array.

An infrared image is captured by an image sensor and a frequency domain infrared image is generated by performing a Fourier transform operation on the infrared image. A filtered frequency domain infrared image is generated by applying a mask to the frequency domain infrared image. A spatial domain infrared image is generated by performing an inverse Fourier transform on the filtered frequency domain infrared image. Phase data is extracted from the spatial domain infrared image and a holographic pattern generated from the phase data is driven onto a display.

Systems and methods for sub-aperture correlation based wavefront measurement in a thick sample and correction as a post processing technique for interferometric imaging to achieve near diffraction limited resolution are described. Theory, simulation and experimental results are presented for the case of full field interference microscopy. The inventive technique can be applied to any coherent interferometric imaging technique and does not require knowledge of any system parameters. In one embodiment of the present application, a fast and simple way to correct for defocus aberration is described. A variety of applications for the method are presented.

A magnetic field controlled guidestar for focusing light deep inside scattering media using optical phase conjugation. Compared with the optical and ultrasonic field, the magnetic field has an exceptional penetration depth. The magnetic particle guidestar has a high light-tagging efficiency, good biocompatibility, and a small diameter which enables a sharp and bright focusing deep inside biological tissue. This new method can benefit a wide range of biomedical applications including deep-tissue imaging, neural modulation, and targeted photothermal and photodynamic therapies.

An image decoding system provides a phase pattern encoding a target image. A spatial light modulator is configured to emit a wavefront-shaped light signal based on the phase pattern. A first diffusive medium receives the wavefront-shaped light signal and emits a decoded scattered light signal of the target image. The target image is previously encoded in the phase pattern by transmitting another wavefront-shaped light signal shaped by a training phase pattern through a second diffusive medium to yield a scattered light signal encoding a test image. The second diffusive medium has the optical scattering characteristics of a first diffusive medium. The scattered light signal encoding the test image is emitted from the second diffusive medium and recorded. The training phase pattern is adjusted for successive iterations of the test image until the test image satisfies a compensation condition. The resulting training phase pattern yields the phase pattern.

Systems and methods for sub-aperture correlation based wavefront measurement in a thick sample and correction as a post processing technique for interferometric imaging to achieve near diffraction limited resolution are described. Theory, simulation and experimental results are presented for the case of full field interference microscopy. The inventive technique can be applied to any coherent interferometric imaging technique and does not require knowledge of any system parameters. In one embodiment of the present application, a fast and simple way to correct for defocus aberration is described. A variety of applications for the method are presented.

An image decoding system provides a phase pattern encoding a target image. A spatial light modulator is configured to emit a wavefront-shaped light signal based on the phase pattern. A first diffusive medium receives the wavefront-shaped light signal and to emit a decoded scattered light signal of the target image. The target image is previously encoded in the phase pattern by transmitting another wavefront-shaped light signal shaped by a training phase pattern through a second diffusive medium to yield a scattered light signal encoding a test image. The second diffusive medium has the optical scattering characteristics of a first diffusive medium. The scattered light signal encoding the test image is emitted from the second diffusive medium and recorded. The training phase pattern is adjusted for successive iterations of the test image until the test image satisfies a compensation condition. The resulting training phase pattern yields the phase pattern.