Systems and methods for handling storage device diagnostics in an Information Handling System (IHS) are described. In an illustrative, non-limiting embodiment, an IHS may include a processor and a memory coupled to the processor, the memory having program instructions stored thereon that, upon execution, cause the IHS to: transmit a request for a storage diagnostic to an engine configured to transform the request into a vendor library call, where the vendor library call is configured to communicate an indication of the request to a storage device driver of a storage device; and receive a response to the request.