A laser-induced plasma (LIP) sound generator comprising: a laser beam and a first beam splitter configured to split the laser into a plurality of sub-laser beams such that each sub-laser beam creates a LIP at a respective focal point, wherein each focal point lies within an imaginary sphere having a radius that is less than half of a desired sound wavelength such that acoustic fields of the LIPs add together as if from a single point source.

Disclosed is a system including a substrate having a first side and a second side and a layer of photoacoustic material disposed on the first side of the substrate. The layer of photoacoustic material is configured to generate a directional ultrasound wave in response to a laser beam impinging on the layer. A conduit may be coupled to the housing and have an opening adjacent to the layer of photoacoustic material; the directional ultrasound wave may be directed through fluid that is contained in the conduct to generate a liquid jet in a liquid.

A method for generating vapour bubbles in an object comprises introducing a composition into the object, the composition comprising carbon-based nano- or microparticles that can couple with a photon wave of electromagnetic radiation. The method also comprises irradiating said object using electromagnetic radiation. The irradiation thereby is adapted for using a set of carbon-based nano- or microparticles for subsequently forming first vapour bubbles and at least second vapour bubbles using the same carbon-based nano- or microparticles.

Disclosed herein is a photoacoustic tomography (PAT) probe to direct light to various regions within the tissue of interest to improve image quality and remove cumbersome artifacts at their source. Particularly, a rotating PAT probe and method of using thereof to improve the photoacoustic penetration depth and signal to noise ratio in biological samples. Signal intensity at region of interest is increased by fine-tuning the fiber orientation with respect to the ultrasound transducer. Additional PA filter is used to prevent in vivo probe-skin artifacts.

A system and an imaging method for using photoacoustic effect are provided in the present invention. The system includes a light source for generating a light beam, a wave-guide probe and an ultrasound receiving device. The wave-guide probe further has a reception portion and at least one transmission portion. The reception portion receives the light beam and then triggers a photoacoustic effect inside the reception portion so as thereby to generate at least one sound wave thereinside to be further transmitted to the at least one transmission portion. The transmission portion is merged into the organic medium. When the sound wave is transmitted to the transmission portion, an ultrasound area is generated inside the organic medium. The ultrasound receiving device is located adjacent to the organic medium, receives the ultrasound generated in the ultrasound area to form an ultrasound image of the organic medium, so as to achieve the imaging method.

Provided herein is a probe for ultrasound imaging of tissue. The probe comprises an optical relay having an optically absorbing coating at the distal end of the probe for generating ultrasound from excitation light via the photoacoustic effect, wherein the generated ultrasound propagates as an ultrasound beam into the tissue; and an ultrasound receiver separate from the optical relay. The optical relay is configured to receive as input a time-varying spatial pattern of excitation light at the proximal end of the probe and to transmit the excitation light to the distal end of the probe to illuminate the optically absorbing coating in accordance with said time-varying spatial pattern, thereby generating ultrasound from the excitation light via the photoacoustic effect to propagate as a scanning ultrasound beam into the tissue. The ultrasound receiver is configured to receive reflections of the ultrasound from tissue. Such an ultrasound probe may be incorporated, for example, into a transseptal puncture needle.

Provided are a laser-induced ultrasound generator and a method of manufacturing the laser-induced ultrasound generator. The laser-induced ultrasound generator includes: a substrate including a plurality of nanostructures provided on a first surface of the substrate; and a thermoelastic layer provided on the first surface of the substrate, the thermoelastic layer being configured to generate an ultrasound by absorbing a laser beam incident onto a second surface of the substrate, the second surface facing the first surface. The nanostructures may be cylinder-shaped nano-pillars.

This invention refers to a device capable of rapidly and efficiently converting the energy in a laser pulse into a high-impulse broadband pressure wave and to its applications in the transient permeabilization of a biological membrane, including the outer layers of the skin, without causing damage or discomfort. A method to deliver drugs and biologically active compounds to or through the skin, or biological barriers, with this device is also disclosed.

A method and apparatus for testing a composite structure. A pulsed laser beam having a number of properties is generated. Each of the number of properties is within a selected range. The pulsed laser beam generated by the generation laser system is directed towards a composite structure comprised of a number of composite materials. A number of ultrasonic waves are formed in the composite structure when the pulsed laser beam contacts the composite structure without causing any undesired inconsistencies in the composite structure outside of selected tolerances.

An object information acquiring apparatus includes: an acoustic wave generating member which absorbs light and generates an acoustic wave; an irradiating unit which irradiates an object or the acoustic wave generating member with light; a detector which detects an acoustic wave propagating from the object; a signal processing unit which generates object information that is information of the inside of the object, based on a signal output from the detector; and a switching unit which performs switching between a first mode in which a first acoustic wave generated inside the object due to irradiation of the light is detected by the detector and a second mode in which a second acoustic wave generated by the acoustic wave generating member due to irradiation of the light and having propagated inside the object is detected by the detector.