An inhaler article includes a body (110) extending along a longitudinal axis from a mouthpiece (112) end to a distal end with an endpiece element at the distal end (114). A capsule cavity is defined within the body. An air inlet region is between the endpiece element (120) and the capsule cavity (116). A composite porous support element (140) defines a downstream end of the capsule cavity. The composite porous support element is formed of a first porous material concentrically disposed about a second porous material. The first porous material has a first resistance to draw and the second porous material having a second resistance to draw. The first resistance to draw is different than the second resistance to draw. A mouthpiece air channel (113) extends from the capsule cavity, through the composite porous element to the mouthpiece end.

An oral dispenser for discharging a liquid in atomized form. This oral dispenser has a liquid reservoir of variable internal volume for receiving the liquid prior to the discharge, and a spring mechanism. When the spring mechanism is loaded, the liquid in the liquid reservoir is placed lastingly under positive pressure. The oral dispenser moreover has an atomization nozzle unit with at least one nozzle opening, and an outlet channel connecting the liquid reservoir to the atomization nozzle unit. An outlet valve in the outlet channel can adopt an opened state and a closed state. A mouthpiece is provided for inhaling the liquid atomized by the atomization nozzle unit. A refill opening is separate from the atomization nozzle unit and connected to the liquid reservoir, wherein the spring mechanism is loaded by liquid fed through the refill opening into the liquid reservoir.

An oral dispenser for discharging a liquid in atomized form. This oral dispenser has a liquid reservoir of variable internal volume for receiving the liquid prior to the discharge, and a spring mechanism. When the spring mechanism is loaded, the liquid in the liquid reservoir is placed lastingly under positive pressure. The oral dispenser moreover has an atomization nozzle unit with at least one nozzle opening, and an outlet channel connecting the liquid reservoir to the atomization nozzle unit. An outlet valve in the outlet channel can adopt an opened state and a closed state. A mouthpiece is provided for inhaling the liquid atomized by the atomization nozzle unit. A refill opening is separate from the atomization nozzle unit and connected to the liquid reservoir, wherein the spring mechanism is loaded by liquid fed through the refill opening into the liquid reservoir.

The present invention provides a passive inhaler for use in treating a number of diseases. The inventor has shown that the compositions comprised in the inhaler can be delivered to the lungs and to the brain in pharmacological relevant dosages, to treat a number of diseases in the lungs and the brain. Further, the inhaler is also able to deliver substances to the brain which may enhance transport across the blood brain barrier.

The present invention provides a passive inhaler for use in treating a number of diseases. The inventor has shown that the compositions comprised in the inhaler can be delivered to the lungs and to the brain in pharmacological relevant dosages, to treat a number of diseases in the lungs and the brain. Further, the inhaler is also able to deliver substances to the brain which may enhance transport across the blood brain barrier.

A nicotine powder consumable article includes an elongated consumable body extending between a proximal end and a distal end. A capsule is fixed within the elongated consumable body. The elongated consumable body contacts the capsule. The capsule contains particles comprising nicotine or a pharmaceutically acceptable salt thereof. A first plug of material is disposed within the elongated consumable body and between the capsule and the proximal end. A second plug of air porous material is disposed within the elongated consumable body and between the capsule and the distal end. The second plug of air porous material is not in air-flow communication with the first plug of material.

A nicotine powder consumable article includes an elongated consumable body extending between a proximal end and a distal end. A capsule is fixed within the elongated consumable body. The elongated consumable body contacts the capsule. The capsule contains particles comprising nicotine or a pharmaceutically acceptable salt thereof. A first plug of material is disposed within the elongated consumable body and between the capsule and the proximal end. A second plug of air porous material is disposed within the elongated consumable body and between the capsule and the distal end. The second plug of air porous material is not in air-flow communication with the first plug of material.

A nicotine powder delivery system includes an inhaler article and a nicotine powder capsule disposed within the inhaler article. The nicotine powder capsule rotates about a longitudinal axis when air flows through the inhaler article.

A nicotine powder delivery system includes an inhaler article and a nicotine powder capsule disposed within the inhaler article. The nicotine powder capsule rotates about a longitudinal axis when air flows through the inhaler article.

An aerosol-generating apparatus includes a mouthpiece, an aerosolizing thermal reactor, and an air preheating passage. The aerosolizing thermal reactor has an air inlet upstream of an aerosol outlet, and includes an aerosolizable substance chamber and a thermal distribution casing. The thermal distribution casing surrounds the aerosolizable substance chamber and includes a laminate material with an at least three-layer construction including a metal middle layer between a metal outer layer and a metal inner layer. The thermal conductivity of the metal inner layer is at least double that of each of the metal outer and inner layers. The air preheating passage is located downstream of the air inlet and upstream of the aerosolizable substance chamber, and surrounds the aerosolizable substance chamber. The air preheating passage is defined by an air gap between the chamber outer wall and the metal inner layer.