Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

Exemplary apparatus and method can be provided for obtaining data regarding a plurality of samples. For example, using at least one arrangement, it is possible to receive interferometric information that is based on radiations provided from a reference and the samples that are provided in respective chambers. Alternatively and/or in addition, based on the interferometric information, it is possible to discriminate between agents to identify a particular agent that affects a particular function within at least one of the samples.

A system for optical coherence tomography includes a source of optical radiation, an optical fiber, and a graded index fiber attached to a distal end of the optical fiber. The optical fiber and the graded index fiber are together configured to provide a common path for optical radiation reflected from a reference interface at a distal end of the graded index fiber and from a target.

A forward looking MEMS based OCT probe (50) is provided that comprises an elongate probe housing (51) having at a first end a probe interface (54) for an optic fibre (56), and at a second opposite end a viewing window (58). The probe housing accommodates a MEMS mirror (10) for sweeping a hght beam (60) through the viewing window and for reflecting light received through the viewing window towards the probe interface, wherein a rotation axis (18) of the MEMS mirror extends transverse to a longitudinal axis (62) defined by the probe housing. The MEMS mirror (10) has a stator (12), a rotor (14), and an actuator (16) with at least one pair of mutually interdigitated comb elements including at least a first comb element fixed to the stator defining a reference plane and at least a second comb element fixed to the rotor and that is further coupled at mutually opposite sides via a respective torsion beam (20A, 20B) to the stator. The rotor has a rotor body (14RB) and a rotor support (14RS), fixed at a first face of the rotor body, that keeps the rotor body at a distance from the stator within said rotation range, the rotor body having a mirror surface (14MS) at a second face opposite the first face, the MEMS mirror comprising the stator (12) and the rotor support (14RS) at mutually opposite sides of the reference plane (RP).

An optical probe (2) for optically examining an object (1) is described, said optical probe having a first optical beam path for a scanning imaging method and a second optical beam path for a spectroscopic method. The optical probe comprises a first optical fibre (9) in the first optical beam path and a scanning apparatus (10) that is configured to laterally deflect the first optical fibre (9) or illumination light (31) emerging from the first optical fibre (9) for the purposes of scanning the object (1) during the scanning imaging method. The optical probe comprises a second optical fibre (11) in the second optical beam path, said second optical fibre being configured to guide excitation light or detected object light for the spectroscopic method, and a beam splitter filter (15), wherein the beam path of the scanning imaging method and the beam path of the spectroscopic method are brought into partial overlap in the probe (2) by means of the beam splitter filter (15). The optical probe (2) has a diameter of no more than 5 mm. Furthermore, a method for operating the optical probe (2) is specified.

Provided is a shape measurement system in order to perform three-dimensional measurement corresponding to a measurement object having various shapes, which includes a measurement probe, a probe tip unit, and a calculation unit. The probe tip unit includes an optical element that is configured to irradiate an object with measurement light, a fixing mechanism that is configured to fix to the measurement probe so as to be detachable and replaceable, and a cylindrical unit that is configured to lock the optical element and is provided with the fixing mechanism.

There are provided devices, systems and methods utilizing interferometric retro-reflection displacement/vibration meter. In particular, there are provided laser interferometer devices, systems and methods for measuring three-axis small angle displacements and vibrations of a body.

An intraoperative probe and a system for optically imaging a surgically significant volume of tissue or other scattering medium. An illumination source generates an illuminating beam that is conveyed to the vicinity of the tissue and a beam splitter, that may be no more than an optical phase reference, splits the illuminating beam into a sample beam along a sample beam path and a reference beam along a reference beam path. A scanning mechanism scans a portion of the sample beam across a section of the scattering medium, while a detector detects return beams from both the reference beam path and the sample beam path and generates an interference signal. A processor computationally moves an effective focus of the sample beam without physical variation of focus of the sample beam. The probe may have a sterilizable fairing that may be detachable.

Some embodiments of a device comprise a light-guiding component; an optical-focusing component, wherein the light-guiding component and the optical-focusing component are aligned on an optical axis; and an optical-correction component that includes a reflecting surface and a correction surface.

Angle multiplexed optical coherence tomography systems and methods can be used to evaluate ocular tissue and other anatomical structures or features of a patient. The angle multiplexed optical coherence tomography system includes a light source, an optical assembly for obtaining a plurality of sample beams corresponding to respective anatomical locations of the eye of the patient, where individual sample beams are associated with a respective non-zero angle relative to a reference beam, and a detection mechanism that detects individual unique interference patterns respectively provided by the plurality of sample beams, for simultaneous evaluation of the anatomical locations.