An object monitoring apparatus including sensors. The apparatus includes first and second sensors that measure mutually corresponding spatial areas; a first judging unit that judges whether an object is present in a predetermined monitored area, based on measurement data of the first sensor; a second judging unit that judges whether an object is present in an extended area extending toward an outside of the monitored area, based on measurement data of the second sensor; a first signal-output unit that outputs a first object-sensing signal, when the first judging unit judges that an object is present in the monitored area; and a second signal-output unit that outputs a second object-sensing signal, when the first judging unit judges that an object is present in the monitored area and in a case where the second judging unit judges that an object is present in the extended area.

According to embodiments of the present invention, an optical imaging device is provided. The optical imaging device includes an optics arrangement configured to generate an extended-source illumination pattern including a plurality of separate spectral bands, and to illuminate a respective section of a sample to be imaged with a respective spectral band of the plurality of separate spectral bands, wherein the optics arrangement is further configured to form an interference signal from a sample light comprising respective return lights from respective sections of the sample illuminated by respective spectral bands of the extended-source illumination pattern, and a reference light, and a detector configured to receive the interference signal for generating an image corresponding to the sections of the sample. According to further embodiments of the present invention, a method for imaging a sample and a method for generating an image are also provided.

A wearable device for high-density-diffuse optical tomography includes a plurality of source modules that include source housings containing a light source. The device also includes a plurality of detector modules that include detector housings, a photodiodes, transimpedance amplifiers operatively coupled to the photodiodes, and analog to digital converters operatively coupled to the transimpedance amplifier. Each detector housing contains at least one of the photodiode, the analog to digital converter, and the transimpedance amplifier. Each source and detector housing is configurable to contact a subject's scalp and deliver or receive light from the scalp at one position. The wearable device also includes a control circuit operatively coupled to the plurality of source modules and to the plurality of detector modules to operate the source and detector modules in a coordinated manner to acquire a plurality of diffuse optical tomography measurements.

The present disclosure provides an OCT imaging system having a variety of advantages. In particular, the OCT system of the present disclosure may provide a more intuitive interface, more efficient usage of controls, and a greater ability to view OCT imaging data.

Multichannel optical coherence systems are disclosed in which optical coherence tomography (OCT) subsystems are operably and respectively connected to optical fibers of a multichannel optical probe, such that each optical fiber forms at least a distal portion of a sample beam path of a respective OCT subsystem. The optical fibers are in optical communication with distal optical elements such that external beam paths associated therewith are directed towards a common spatial region external to the housing. Image processing computer hardware is employed to process OCT signals obtained from the plurality of OCT subsystems to generate an OCT image dataset comprising a plurality of OCT A-scans and process the OCT image dataset to generate volumetric image data based on known positions and orientations of the external beam paths associated with the OCT subsystems.

An object monitoring apparatus including sensors. The apparatus includes first and second sensors that measure mutually corresponding spatial areas; a first judging unit that judges whether an object is present in a predetermined monitored area, based on measurement data of the first sensor; a second judging unit that judges whether an object is present in an extended area extending toward an outside of the monitored area, based on measurement data of the second sensor; a first signal-output unit that outputs a first object-sensing signal, when the first judging unit judges that an object is present in the monitored area; and a second signal-output unit that outputs a second object-sensing signal, when the first judging unit judges that an object is present in the monitored area and in a case where the second judging unit judges that an object is present in the extended area.

A central question in cancer therapy is how individual cells within a population of tumor cells respond to drugs designed to arrest their growth. However, the absolute growth of cells, their change in physical mass, whether cancerous or physiologic, is difficult to measure directly with traditional techniques. Embodiments of the invention provide live cell interferometry (LCI) for rapid, realtime quantification of cell mass in cells exposed to a changing environment. Overall, LCI provides a conceptual advance for assessing cell populations to identify, monitor, and measure single cell responses, such as to therapeutic drugs.

A method for improving an OCT image of an object such as the retina of an eye, using optical coherence tomography by an imaging beam path. In order to suppress shadowing effects due to a surgical instrument moved in the imaging beam path, a time series of OCT images is produced. For an OCT image to be corrected, an area of the object lying in the image and shadowed by the instrument is determined. Another earlier OCT image in which the area of the object is not shadowed is searched in the time series. Image information for the area of the object is read from the earlier OCT image. A corrected OCT image is produced by inserting the read-image information into the OCT image to be corrected, wherein in the OCT image to be corrected, the image information replaces the area of the object which is shadowed by the instrument.

A phase-resolved heterodyne shearing interferometer has been developed for high-rate, whole field observations of transient surface motion. The sensor utilizes polarization multiplexing and multiple carrier frequencies to separate each segment of a shearing Mach-Zehnder interferometer. Post-processing routines have been developed to recombine the segments by extracting the scattered object phase from Doppler shifted intermediate carrier frequencies, providing quantitative relative phase changes and information to create variable shear, phase resolved shearographic fringe patterns without temporal or spatial phase shifting.

The present disclosure provides an OCT imaging system having a variety of advantages. In particular, the OCT system of the present disclosure may provide a more intuitive interface, more efficient usage of controls, and a greater ability to view OCT imaging data.