A measurement system is provided with an array of laser diodes with one or more Bragg reflectors. At least a portion of the light generated by the array is configured to penetrate tissue comprising skin. A detection system configured to: measure a phase shift, and a time-of-flight, of at least a portion of the light from the array of laser diodes reflected from the tissue relative to the portion of the light generated by the array; generate one or more images of the tissue; detect oxy- or deoxy-hemoglobin in the tissue; non-invasively measure blood in blood vessels within or below a dermis layer within the skin; measure one or more physiological parameters based at least in part on the non-invasively measured blood; and measure a variation in the blood or physiological parameter over a period of time.

An active remote sensing system is provided with an array of laser diodes that generate light directed to an object having one or more optical wavelengths that include at least one near-infrared wavelength between 600 nanometers and 1000 nanometers. One of the laser diodes pulses at a modulation frequency between 10 Megahertz and 1 Gigahertz and has a phase associated with the modulation frequency. A detection system includes a photo-detector, a lens, a spectral filter at an input to the photo-detector, and a processor that processes digitized signals received from the photo-detector to generate an output signal. The detection system uses a lock-in technique that synchronizes pulsing the one laser diode. The active remote sensing system is configured to be mounted on a vehicle or an airborne platform to provide distance information based on a time-of-flight measurement.

Embodiments of the invention provide Raman spectroscopy methods and devices that exploit high quality factor (Q) resonators to enhance Raman signal by several orders of magnitude over the signal typically expected for Raman methods. Embodiments typically include one or more resonators, typically microtoroid microresonators. Embodiments also take advantage of Rayleigh scattering using these microresonators. Embodiments may be particularly useful for non-labeled nanoparticle sensing.

A microplate reader includes a pair of linear variable filters (LVFs) that together form a wavelength selector. Movement of one or both of the LVFs enables selection of the desired center wavelength and/or passband used to analyze a sample on a microplate inserted into the microplate reader. The microplate reader may also include a similar second wavelength selector. The LVFs are located on movable frames, with each frame also advantageously including least one of an aperture, a fixed optical filter, and an optical polarization filter. In some cases, different types of measurements may be taken without changing the geometry of the optical path between the wavelength selectors. The microplate reader may additionally use a LVF to form a continuously adjustable dichroic for sample analysis.

A noise reduction device capable of reducing noise over a wide frequency range and a detection apparatus including the same are provided. The noise reduction device includes a splitting unit configured to split pulsed light generated in a first period into three or more pulsed light beams, a delaying unit configured to provide the three or more pulsed light beams with different delay times, and a combining unit configured to combine the three or more pulsed light beams. Among the three or more pulsed light beams, two pulsed light beams whose delay times provided by the delaying unit are closest to each other are configured such that a difference between their delay times is equal to the first period.

An optical spectrum analyzer is provided that can separate measurement target light into orthogonal polarization components and perform measurement and enable optical spectrum measurement that does not depend on polarization of the measurement target light. Measurement target light is separated into two orthogonal polarization components, the two polarization components whose position is shifted in an engraved line direction of a diffraction grating are incident on the diffraction grating, diffracted light of the two polarization components emitted from the diffraction grating is condensed, and the condensed diffracted light is incident on an incident side end surface of a 2-core ferrule with the two polarization components adjacent to each other.

An optical assembly is disclosed including two laterally variable bandpass optical filters stacked at a fixed distance from each other, so that the upstream filter functions as a spatial filter for the downstream filter. The lateral displacement may cause a suppression of the oblique beam when transmission passbands at impinging locations of the oblique beam onto the upstream and downstream filters do not overlap. A photodetector array may be disposed downstream of the downstream filter. The optical assembly may be coupled via a variety of optical conduits or optical fibers for spectroscopic measurements of a flowing sample.

Methods, apparatus and systems that relate to a low-cost reconfigurable polarimetric imaging are described. One example polarization imaging system includes a lens positioned to receive light reflected from one or more objects, and a spectral-polarization filter positioned at an aperture plane of the lens to filter the light received by the lens. The polarization imaging system can further include a sensor positioned to detect the filtered light from the spectral-polarization filter to form a polarization image of the one or more objects. The spectral-polarization filter comprises a first array of multiple spectral filters and a second array of multiple polarizers.

The invention is directed to a hyperspectral/multispectral system referred to as the OxyVu-1 system. The hyperspectral imaging technology performs spectral analysis at each point in a two-dimensional scanned area producing an image displaying information derived from the analysis. For the OxyVu-1 system, the spectral analytical methods determined in superficial tissues approximate values of oxygen saturation (HT-Sat), oxyhemoglobin levels (HT-Oxy), and deoxyhemoglobin levels (HT-Deoxy). The OxyVu-1 system displays the tissue oxygenation in a two-dimensional, color-coded image. The system contains a system console, a cart, system electronics, CPU, monitor, keyboard, pointing device and printer. The hyperspectral instrument head with support arm contains broadband illuminator, camera and spectral filter for collecting hyperspectral imaging cube. The single use OxyVu Check Pads and Targets are used to perform an instrument check prior to patient measurements. The OxyVu Target is placed within the intended field of view and is used as a fiduciary mark for image registration and for focusing.

A spectroscope device is provided to maintain the uniformity of the central transmitting wavelength in the field of view and to minimize the broaden of the bandwidth of the transmitting wavelengths in an optical lens using an optical tunable filter (variable wavelength filter), even with a wide field of view and/or a large numerical aperture. A space is defined in which, when each beam that is incident from each off-axial object point on the object surface toward the optical lens that includes a plurality of lens elements between an object surface and a conjugate real image surface reaches the optical tunable filter, the chief ray is maintained parallel to the optical axis. Therefore, if an optical tunable filter is disposed in this space, each beam is always incident normal to the filter, so only the narrow band components at the specific central wavelength can be transmitted.