There is provided an image module package including a substrate, a photo sensor chip, a molded transparent layer and a glass filter. The substrate has an upper surface. The photo sensor chip is attached to the upper surface of the substrate and electrically connected to the substrate. The molded transparent layer covers the photo sensor chip and a part of the upper surface of the substrate, wherein a top surface of the molded transparent layer is formed with a receptacle opposite to the photo sensor chip. The glass filter is accommodated in the receptacle.

A method including generating integrated computational element (ICE) models and determining a sensor response as the projection of a convolved spectrum associated with a sample library with a plurality of transmission profiles determined from the ICE models. The method includes determining a regression vector based on a multilinear regression that targets a sample characteristic with the sensor response and the sample library and determine a plurality of regression coefficients in a linear combination of ICE transmission vectors that results in the regression vector. The method further includes determining a difference between the regression vector and an optimal regression vector. The method may also include modifying the ICE models when the difference is greater than a tolerance, and fabricating ICEs based on the ICE models when the difference is within the tolerance. A device and a system for optical analysis including multiple ICEs fabricated as above, are also provided.

An in-situ photocatalysis monitoring system based on surface-enhanced Raman Scattering (SERS) spectroscopy. The monitoring system may include a Raman excitation light source, a laser coupling lens, a narrow band filter, a total reflection mirror, a dichroic mirror, a focusing coupling lens, a SERS optical fiber probe, a liquid phase photocatalysis reactor, a photocatalytic light source, a Raman collection lens, and a spectrometer. A first furcation part and a second furcation part each extend from one end of a common detection part of the SERS optical fiber probe; an extending end of the first furcation part is coupled with the focusing coupling lens; an extending end of the second furcation part is coupled with the photocatalytic light source; and the other end of the common detection part is arranged inside the liquid phase photocatalysis reactor. Raman excitation light and photocatalytic light may be transmitted on a common channel.

An optical device may include an optical filter array comprising an array of bandpass filters, and a liquid-crystal (LC) panel comprising an array of LC regions. An aspect ratio of the LC panel may match an aspect ratio of the optical filter array such that each LC region, of the array of LC regions, is associated with a respective bandpass filter of the array of bandpass filters A LC region, of the array of LC regions, may selectively transmit light that is incident on the LC region.

A flow cytometry measurement system is disclosed which includes a flow chamber configured to flow particles of interest in a flow stream, one or more optical sources configured to excite the particles of interest by an excitation light activated and deactivated according to a pulse train thus causing particles of interest emitting emission light, one or more sensor packages each comprising a plurality of photodetectors configured to receive emission light from the particles of interest and, in response, provide an output voltage signal and an output current signal corresponding to photoelectron response of an incident photon on the one or more sensor packages, and a detector configured to determine successive single molecular decay of the particles of interest, generate an emission pulse associated with each incident photon on the one or more sensor packages, and count the number of emission pulses.

According to some embodiments, a Micro Wideband Spectroscopic Analysis Device (MWSAD) is designed to operate from the visible to the far infrared. The MWSAD is the first unified platform to implement nearly all kind of molecular spectroscopy. This design is based on combining/integrating Diffractive Focusing Element (DFE) such as Fresnel lens/Zone plate with wide and finite range tuning devices. The wide range tuning devices are tunable lenses and/or a long stroke linear motor. The finite tuning devices are micro pinhole controlled by MEMS/PZT actuator. The MEMS/PZT actuator is used for finite tuning the micro pinhole location across the chromatic focuses of the Fresnel lens/DFE. The long stroke linear motor is used for wide range tuning the pinhole location across the chromatics focuses. The tunable lens is used for wideband tuning the chromatics focuses locations within the micro pinhole.

A Raman spectroscopy system is provided. The spectroscopy system includes an optical switch including a first side having a pump inlet and a return outlet, and a second side having a plurality of pump outlets and a plurality of return inlets. The spectroscopy system includes at least one radiation source optically coupled to the pump inlet and a detector optically coupled to the return outlet. The spectroscopy system further includes a pump filter module optically coupled between the at least one radiation source and the pump outlets and a return filter module optically coupled between the detector and the return inlets. The spectroscopy system further includes a plurality of probes, each probe optically connected to at least one of the plurality of pump outlets by at least one excitation fiber and optically coupled to one of the return inlets by at least one emission fiber.

An apparatus may include an anti-color filter array proximate an array of optical sensor pixels. The anti-color filter array may include first anti-color filters. Each of the first anti-color filters may be located near a corresponding instance (or group of instances) of a first plurality of optical sensor pixels and may be configured to at least partially suppress transmission of light in a first optical wavelength range. In some examples, the first optical wavelength range may correspond to a first color. The anti-color filter array may include second anti-color filter regions, each of which may be located near a corresponding instance of a second plurality of optical sensor pixels. In some such examples, each of the second anti-color filter regions may be configured to at least partially suppress transmission of light in a second optical wavelength range.

A measurement system includes an optical source (e.g., laser) to irradiate a sample (e.g., a cell); a solid-state photon detector (SSPD) to receive resultant light from the sample; and a photon counter to count photons received by the SSPD. The photon counter can include a differentiator to provide a differentiated photon signal and a crossing detector configured to count photons based on a number of times the differentiated photon signal crosses a predetermined threshold level. In some examples, a pulse detector can provide a pulse-width signal from the SSPD output photon signal, and a pulse counter can count based on both a number of pulses and widths of the pulses. The SSPD can include a silicon photomultiplier (SiPM) array or a solid-state photomultiplier. Some examples use the measurement system to measure samples in fluids, e.g., in flow cytometers or multi-well plates.

An in-situ photocatalysis monitoring system based on surface-enhanced Raman Scattering (SERS) spectroscopy. The monitoring system may include a Raman excitation light source, a laser coupling lens, a narrow band filter, a total reflection mirror, a dichroic mirror, a focusing coupling lens, a SERS optical fiber probe, a liquid phase photocatalysis reactor, a photocatalytic light source, a Raman collection lens, and a spectrometer. A first furcation part and a second furcation part each extend from one end of a common detection part of the SERS optical fiber probe; an extending end of the first furcation part is coupled with the focusing coupling lens; an extending end of the second furcation part is coupled with the photocatalytic light source; and the other end of the common detection part is arranged inside the liquid phase photocatalysis reactor. Raman excitation light and photocatalytic light may be transmitted on a common channel.