An optical microscope according to one aspect of the present disclosure includes: a light source; a first scanner to scan a spot position of a light beam on a sample; an objective lens to focus the light beam deflected by the first scanner and cause the light beam to be made incident on the sample; a spectroscope including a slit on an incident side which an outgoing light emitted from an area on the sample onto which the light beam has been illuminated enters; a detector configured to detect an outgoing light from the spectroscope; and a first relay optical system including a first off-axis parabolic mirror that is arranged in an optical path from the first scanner to the objective lens and reflects the light beam deflected by the first scanner and a second off-axis parabolic mirror that reflects the light beam reflected in the first off-axis parabolic mirror.

A CubeSat compatible spectrometer including a slit having a first length and first width; a diffraction grating; and a two dimensional focal plane array electromagnetically coupled to the diffraction grating. The 2D focal plane array includes an array of pixels including a plurality of sets of pixels. Diffraction of electromagnetic radiation transmitted through the slit by the diffraction grating forms a plurality of beams, each of the beams comprising a different one of the bands of the wavelengths in the electromagnetic radiation, and each of the beams transmitted onto a different one of the sets of the pixels.

A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.

An optical system measures one or more physiological parameters with a wearable device that includes a light emitting diode (LED) source including a driver and a plurality of semiconductor sources that generate an output optical light. One or more lenses deliver a lens output light to tissue of a user. A detection system receives at least a portion of the lens output light reflected from the tissue and generates an output signal having a signal-to-noise ratio. The detection system comprises a plurality of spatially separated detectors and an analog to digital converter. The detection system increases the signal-to-noised ratio by comparing a first signal with the LEDs off to a second signal with the LEDs on. An imaging system including a Bragg reflector is pulsed and has a near infrared wavelength. A beam splitter splits the light into a sample arm and a reference arm to measure time-of-flight.

The present invention relates to a hyperspectral apparatus and method. One aspect of the invention provides an apparatus for analyzing a sample. The apparatus comprises a light source configured to generate a broadband input irradiance field. The apparatus also comprises a structured light generator for converting the input irradiance field into a structured illumination field including an array of beamlets. An optical system projects the structured illumination field onto a region of the sample such as the retina. A spectrometer is configured to spectrally analyze a portion of light that is reflected, backscattered or fluoresced from the region of the sample. A processor is operatively associated with the spectrometer and configured to generate a hyperspectral image comprising two or more en-face images of the region of the eye. The en-face images include spectral response information of the sample from each beamlet of the structured illumination field.

Provided is a single-axis rotary actuator that is suitable for rotationally driving an optical element, such as a diffraction grating, in a single-axis direction and that is suitable for forming light having a wide wavelength band. An actuator (500) includes a holder (550) having a mounting surface on which a diffraction grating (401) is attached and a rotary shaft (552); a fixed unit (520) having a bearing that holds the rotary shaft (552) of the holder (550); an elastic member (530) formed of an outer circumferential section fixed on the fixed unit (520), an inner circumferential section fixed on the holder (550), and an arm section interconnecting the outer circumferential section and the inner circumferential section and having elasticity; and a driving unit having a coil (540) provided on the holder (550) and a magnet (510) provided on the fixed unit (520).

A system and method for imaging a sample using Raman spectrometry. Optical fibers having opposite first ends and second ends are arranged with the first ends and second ends in respective two-dimensional arrays. The two-dimensional arrays maintain relative positions of the optical fibers to one another from the first ends to the second ends in a way that the first end of each optical fibers of the bundle can simultaneously collect a corresponding Raman signal portion scattered from specific spatial coordinates of the area of the sample. The so-collected Raman signal portions are propagated towards the corresponding second end, from which are outputted and detected simultaneously using an array of detectors.

A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.

The present disclosure provides Raman spectrum detection apparatus and method. The Raman spectrum detection apparatus includes: a laser configured for emitting excited light; an optics assembly configured to guide the excited light along a first light path to a sample to be detected and to collect a light signal from the sample along a second light path; and a spectrometer configured to process the light signal collected by the optics assembly so as to generate a Raman spectrum of the detected sample. The optics assembly includes a first optical element configured to move, during irradiation of the excited light onto the sample, so as to change a position of a light spot of the excited light on the sample.

A measurement system is provided with an array of laser diodes with one or more Bragg reflectors. At least a portion of the light generated by the array is configured to penetrate tissue comprising skin. A detection system configured to: measure a phase shift, and a time-of-flight, of at least a portion of the light from the array of laser diodes reflected from the tissue relative to the portion of the light generated by the array; generate one or more images of the tissue; detect oxy- or deoxy-hemoglobin in the tissue; non-invasively measure blood in blood vessels within or below a dermis layer within the skin; measure one or more physiological parameters based at least in part on the non-invasively measured blood; and measure a variation in the blood or physiological parameter over a period of time.