Biosensing platform for simultaneous, multiplexed, high throughput and ultra-sensitive optical detection of biomarkers labelled with plasmonic nanoparticles, the platform being provided with a biosensor, a broadband and continuous spectrum illumination source, an optical detector for simultaneously capturing spatially resolved and spectrally resolved the scattering signal of each individual nanoparticle, an autofocus system and an optical system adapted to collect the scattered signal of the biosensor's surface onto the optical detector, the platform being provided with translation means for the optical system and/or the biosensor, such that the optical system and the biosensor can be displaced relative to each other in the three dimensions, and wherein the processing means are adapted to: i) simultaneously capture spatially and spectrally resolved scattering signals from each nanoparticle individually, and ii) to analyze these signals simultaneously with the capture process.

A nano-structured optical wavelength transmission filter is provided. The optical filter includes a patterned substrate on which a high refractive index dielectric waveguide is arranged. A low index dielectric layer is arranged on the high refractive index dielectric waveguide, on which an array of metallic nanostructures is arranged. The layers of the optical filter have conformal shapes defined by a patterned surface of the substrate. An optical filter system includes the optical transmission filter and a detector array fixed to the substrate. A spectrometer includes at least one optical transmission filter and/or at least one said optical transmission filter system, and has a spectral resolution of lower than 30 nm for incident light having a wavelength between 300 nm and 790 nm. A method of fabrication of an optical filter, an optical filter system and a spectrometer is also described.

Disclosed herein are a detector array, a spectrometer system including the detector array and a method of using of the spectrometer system. The detector array includes a substrate; and a plurality of detector pixels applied to a surface of the substrate, where each detector pixel has a sensor region which is designated for receiving a partition of incident light, where each detector pixel is designated for generating a sensor signal depending on an intensity of the partition of the incident light received by the sensor region of the detector pixel, where at least two adjacent detector pixels share a single connection to a common electric potential, and where the sensor regions of at least two of the detector pixels differ with respect to each other by an area of the corresponding sensor region.

The present disclosure generally relates to hyperspectral spectroscopy, and in particular, to systems, methods and devices enabling a single-sensor hyperspectral imaging device. Hyperspectral (also known as “multispectral”) spectroscopy is an imaging technique that integrates multiples images of an object resolved at different narrow spectral bands (i.e., narrow ranges of wavelengths) into a single data structure, referred to as a three-dimensional hyperspectral data cube. Data provided by hyperspectral spectroscopy allow for the identification of individual components of a complex composition through the recognition of spectral signatures of individual components within the three-dimensional hyperspectral data cube.

Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.

A filter array includes optical filters that are disposed in a two-dimensional plane. At least one optical filter of the optical filters includes an interference layer having a first surface and a second surface opposite the first surface, and a reflective layer provided on the first surface. A transmission spectrum of the at least one optical filter has maximum values. The reflective layer is not provided on the second surface.

A handheld spectrometer can be configured with a visible aiming beam to allow the user to determine the measured region of the object. When the visible aiming beam comprises the spectrometer measurement beam, the spectrometer measurement beam comprises sufficient energy for the user to see the measurement beam illuminating the object. When the visible aiming beam comprises a separate beam, the visible aiming beam comprises sufficient energy for the user to see a portion of the aiming beam reflected from the object. The visible aiming beam and measurement beam can be arranged to at least partially overlap on the sample, such that the user has an indication of the area of the sample being measured.

A system includes a first spectral modulator, a second spectral modulator, a light guide optically, a photodetector, and an electronic control device. The first spectral modulator receives sample light, and modulates the sample light according to a first spectral response pattern to produce first modulated light. The second spectral modulator receives the first modulated light from the first spectral modulator via the light guide, modulates the first modulated light according to a second spectral response pattern to produce second modulated light, and transmits the second modulated light to the photodetector. The photodetector measures an intensity of the second modulated light incident on the photodetector, and generates one or more signals corresponding to the intensity of the second modulated light. The electronic control device determines a spectral distribution of the sample light based on the one or more signals.

A filter array includes filters disposed in a two-dimensional plane and having different transmission spectra. The filters include a first filter with a transmission spectrum having a first peak group including first and second peaks adjacent to each other, and at least one second filter with a transmission spectrum having a second peak group including third and fourth peaks adjacent to each other. Of peaks included in the second peak group, the third peak has a wavelength closest to a wavelength at the first peak. A first interval between the wavelength at the first peak and a wavelength at the second peak is different from a second interval between the wavelength at the third peak and a wavelength at the fourth peak. ΔFSR/σ≥0.25, where ΔFSR denotes an absolute value of a difference between the first and second intervals and σ denotes a half-width of the first peak.

An optical filter structure of an arbitrary combination of UV, R, G, B, and IR includes a substrate and a filter layer. The substrate is a wafer semiconductor sensor device and a product of light-transmitting device. The filter layer is formed on a surface of the substrate and is formed of a plurality of basic units arranged in an array. Each of the basic units includes a plurality of pixel filter films formed through vacuum coating, and the plurality of pixel filter films include an arbitrary combination of multiple ones of a UV pixel filter film, an R pixel filter film, a G pixel filter film, a B pixel filter film, and an IR pixel filter film, such that the plurality of pixel filter films allow light of corresponding wavelengths to pass therethrough.