G01J3/427

Dual-comb spectroscopy

A gain switched dual comb spectroscopy device for spectroscopically detecting a sample substance, comprising a first slave laser light source configured to generate a first frequency comb having a first comb free spectral range, and a second slave laser light source configured to generate a second frequency comb having a second comb free spectral range which is different from the first comb free spectral range. A master laser light source is configured to inject seed light in to both slave laser light sources therewith to injection lock the generation of both the first and the second frequency combs. A photodetector part is arranged to combine the first and the second frequency combs and to detect a beat signal the spectrum of which comprises a third frequency comb including beat tones produced by interference between the combined first and second frequency combs.

Dual-comb spectroscopy

A gain switched dual comb spectroscopy device for spectroscopically detecting a sample substance, comprising a first slave laser light source configured to generate a first frequency comb having a first comb free spectral range, and a second slave laser light source configured to generate a second frequency comb having a second comb free spectral range which is different from the first comb free spectral range. A master laser light source is configured to inject seed light in to both slave laser light sources therewith to injection lock the generation of both the first and the second frequency combs. A photodetector part is arranged to combine the first and the second frequency combs and to detect a beat signal the spectrum of which comprises a third frequency comb including beat tones produced by interference between the combined first and second frequency combs.

METHODS OF ASSESSING ANTIBODY-DRUG CONJUGATES
20210172866 · 2021-06-10 ·

The present disclosure provides methods of assessing DAR of ADC products that provide advantages over known methods. Specifically, methods of the disclosure can be used in high-throughput applications and/or without having to dilute ADC samples during the assessment.

METHODS OF ASSESSING ANTIBODY-DRUG CONJUGATES
20210172866 · 2021-06-10 ·

The present disclosure provides methods of assessing DAR of ADC products that provide advantages over known methods. Specifically, methods of the disclosure can be used in high-throughput applications and/or without having to dilute ADC samples during the assessment.

Method and Apparatus for Light-Weight, Non-Invasive, Point of Care Diabetes Screening Device
20210196155 · 2021-07-01 ·

A multi-channel measurement device for measuring properties of human tissue, may comprise a microcontroller and first and second source/sensor complexes. The first source/sensor complex may include a first housing having a first measurement portion, a first light sensor coupled to the microcontroller and exposed to the first measurement portion, and a first plurality of light sources coupled to the microcontroller and exposed to the first measurement portion. The second source/sensor complex may include a second housing having a second measurement portion, a second light sensor coupled to the microcontroller and exposed to the second measurement portion, and a second plurality of light sources coupled to the microcontroller and exposed to the second measurement portion. The first and second source/sensor complexes are coupled to each other such that the first measurement portion is opposite the second measurement portion and human tissue may be placed between the the first and second measurement portions. The microprocessor is configured with instructions stored in non-volatile memory to individually activate each of the light sources of the first and second pluralities of light sources and to record light intensity detected by the first and second light sources while an individual light source is activated. Each combination of an individually activated light source and one of the first and second light sensors provides a distinct measurement channel for measuring the absorption spectra of human blood and tissue.

Method and Apparatus for Light-Weight, Non-Invasive, Point of Care Diabetes Screening Device
20210196155 · 2021-07-01 ·

A multi-channel measurement device for measuring properties of human tissue, may comprise a microcontroller and first and second source/sensor complexes. The first source/sensor complex may include a first housing having a first measurement portion, a first light sensor coupled to the microcontroller and exposed to the first measurement portion, and a first plurality of light sources coupled to the microcontroller and exposed to the first measurement portion. The second source/sensor complex may include a second housing having a second measurement portion, a second light sensor coupled to the microcontroller and exposed to the second measurement portion, and a second plurality of light sources coupled to the microcontroller and exposed to the second measurement portion. The first and second source/sensor complexes are coupled to each other such that the first measurement portion is opposite the second measurement portion and human tissue may be placed between the the first and second measurement portions. The microprocessor is configured with instructions stored in non-volatile memory to individually activate each of the light sources of the first and second pluralities of light sources and to record light intensity detected by the first and second light sources while an individual light source is activated. Each combination of an individually activated light source and one of the first and second light sensors provides a distinct measurement channel for measuring the absorption spectra of human blood and tissue.

Method and System for Real-Time Web Manufacturing Supervision
20210164912 · 2021-06-03 · ·

A web manufacturing supervision system for monitoring properties of a web being transported in a moving direction during a web manufacturing process, includes: a) a radiation source for illuminating a first spot on the web; b) a tunable first detector for capturing signal radiation emanating from the first spot within a signal wavelength band; the signal wavelength band being adjustable to one of at least a first wavelength band and a second wavelength band; c) a second detector for capturing reference radiation emanating from the first spot within a reference wavelength band; d) control means for alternatingly tuning the signal wavelength band to the first wavelength band and the second wavelength band and measuring the signal at both wavelength bands simultaneously.

Method and System for Real-Time Web Manufacturing Supervision
20210164912 · 2021-06-03 · ·

A web manufacturing supervision system for monitoring properties of a web being transported in a moving direction during a web manufacturing process, includes: a) a radiation source for illuminating a first spot on the web; b) a tunable first detector for capturing signal radiation emanating from the first spot within a signal wavelength band; the signal wavelength band being adjustable to one of at least a first wavelength band and a second wavelength band; c) a second detector for capturing reference radiation emanating from the first spot within a reference wavelength band; d) control means for alternatingly tuning the signal wavelength band to the first wavelength band and the second wavelength band and measuring the signal at both wavelength bands simultaneously.

Optical gas sensor
11022547 · 2021-06-01 · ·

A gas sensor comprises a chamber configured to receive a gas; a light source configured to emit a light wave propagating through the chamber in an emission cone; a measurement photodetector and a reference photodetector, each configured to detect a light wave emitted by the light source and having passed through the chamber. The chamber extends between two transverse walls, arranged opposite one another and connected to one another by a peripheral wall extending therebetween, about a longitudinal axis (Z), and comprising a first reflective segment configured to receive a first portion of the emission cone to reflect it toward the measurement photodetector, thus forming a measurement cone converging toward the measurement photodetector. A second reflective segment of the peripheral wall is configured to receive a second portion of the emission cone to reflect it toward the reference photodetector, thus forming a reference cone converging toward the reference photodetector.

Optical gas sensor
11022547 · 2021-06-01 · ·

A gas sensor comprises a chamber configured to receive a gas; a light source configured to emit a light wave propagating through the chamber in an emission cone; a measurement photodetector and a reference photodetector, each configured to detect a light wave emitted by the light source and having passed through the chamber. The chamber extends between two transverse walls, arranged opposite one another and connected to one another by a peripheral wall extending therebetween, about a longitudinal axis (Z), and comprising a first reflective segment configured to receive a first portion of the emission cone to reflect it toward the measurement photodetector, thus forming a measurement cone converging toward the measurement photodetector. A second reflective segment of the peripheral wall is configured to receive a second portion of the emission cone to reflect it toward the reference photodetector, thus forming a reference cone converging toward the reference photodetector.