A Raman spectrum inspection apparatus is provided, including: a exciting light source configured to emit an exciting light to a sample to be inspected; an optical device configured to collect an optical signal from a position, which is irradiated by the exciting light, of the sample to be inspected; and a spectrometer configured to generate a Raman spectrum of the sample to be inspected from the received optical signal, wherein an excitation optical path in which the exciting light passes from the exciting light device to the sample to be inspected and a detection optical path in which the optical signal received by the spectrometer passes from the sample to be inspected to the spectrometer are separated from each other.

Disclosed is an apparatus and method for processing a bio optical signal based on a spread spectrum scheme including a demodulator configured to collect a bio optical signal generated in response to an incident beam modulated based on a spreading code being scattered from a target analyte, and remove a noise from the bio optical signal by demodulating the bio optical signal based on the spreading code, wherein the bio optical signal has a correlation with the modulated incident beam.

Systems and methods for time-resolved spectroscopy. Exemplary methods include: providing first, second, and third light using an excitation source; receiving first scattered light from a material responsive to the providing the first light; signaling the detector, after a delay, to provide a first spectrum of the received first scattered light; receiving second scattered light from the material responsive to the providing the second light; signaling the detector, after the delay, to provide a second spectrum of the received second scattered light; receiving third scattered light from the material responsive to the providing the third light; signaling the detector, after the delay, to provide a third spectrum of the received third scattered light; recovering a spectrum of the material using the first spectrum, second spectrum, and third spectrum; and identifying at least one molecule of the material using the recovered spectrum and a database of identified spectra.

A spectroscopy system (10) for analyzing in-elastic scattered electromagnetic radiation from an object being irradiated by electromagnetic radiation is provided. The system comprises a tunable lens assembly (13) having a tunable lens provided in the beam path between an electromagnetic radiation source (11) and the object (0) and arranged to project a beam of electromagnetic radiation emitted from the electromagnetic radiation source onto an area of the object and receive and collimate the in-elastic scattered electromagnetic radiation from the object. Based on electromagnetic radiation detected by at least a first detector (121) a control unit (14) is capable making a decision to change the operational settings of the tunable lens.

Aspects of Raman spectrum plane imaging device(s), belonging to the technical field of Raman spectra, are disclosed. In one example, a Raman spectrum plane imaging device may comprise a laser generation apparatus capable of adjusting an output wavelength, a light filtering apparatus, and a planar array detector. Laser light beams emitted by such laser generation apparatus may irradiate on a surface of a sample in a planar illuminating manner. According to systems herein, Raman scattered light generated by the sample under the excitation of the laser light beams is incident on the light filtering apparatus and is imaged on the planar array detector after selectively passing through the light filtering apparatus, to be received by the planar array detector. In some implementations, the light filtering apparatus may comprise an F-P interference device and a band-pass light filter.

A method of achieving instrument independent measurements for quantitative analysis of fiber-optic Raman spectroscope system, the system comprising a laser source, a spectroscope and a fiber optic probe to transmit light from the laser source to a target and return scattered light to the spectroscope, the method comprising transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration system and generating a probe and/or probe-system transfer function, and storing the transfer function. Further provided is a method of performing real-time diagnostic Raman spectroscopy optionally in combination with the other disclosed methods.

A system, apparatus, and method for multiple wavelength Raman interrogation laser generation and Raman spectra acquisition. An intracavity laser tuning subsystem is integrated into the laser cavity. The tuning subsystem allows switching between at least two laser output frequencies in a manner effective for good identification and separation of Raman spectra from non-Raman spectra, including auto-fluorescence from the sample and background. The tuning subsystem can be implemented in different ways in the cavity. It does not require material alteration of the line-narrowing components. Also, processing of acquired raw signal from the multiple wavelength interrogation can further assist effective Raman spectra identification and separation.

A method of performing Raman spectroscopy comprising: generating wavelength shifted excitation light for exciting a Raman response from at least one sample, wherein the wavelength shifted excitation light comprises at least two excitation wavelengths; providing the wavelength shifted excitation light to the at least one sample and collecting signal light from the at least one sample; obtaining response signals from the collected signal light; processing the obtained response signals to determine a Raman response and a fluorescence response, wherein determining the Raman response uses at least one characteristic of an expected Raman response to the wavelength shifted excitation light and wherein determining the fluorescence response uses at least one characteristic of an expected fluorescence response to the shifted excitation light.

Optical data captured in an optical system may be distorted or otherwise affected by various factors, such as but not limited to physical interference, fluorescence, noise or other factors. The effects on the optical data may interfere with any number of uses of the optical data, such as identification, presentation, or the like. Although various embodiments are provided, such as but not limited to spectroscopy, chromatography, and image processing, these are merely example embodiments, and the processing and/or removal of one or more components within the optical data to account for the distortions or other effects. Other applications may include any x, y or x, y, z dataset of optical data.

A transient grating (TG) is used as an optical gating element with sub-picosecond time resolution for luminescence measurements from a photo-detector array. The transient grating is formed in a gate medium by one or more pulsed gate beams. For photoluminescence measurements such as photoluminescence spectroscopy or imaging, a source is excited by a pulsed excitation beam, and the pulsed gate beams are synchronized to the pulsed excitation beam with an adjustable delay between the excitation of the source and the formation of the TG. Moreover, a source or its spectra can be imaged at two different regions of the photo-detector array at two different times spaced in time by a selected duration of time with sub-picosecond resolution over a range of a nanosecond or more. A beam from the source is deflected to the different regions by changing the frequency or geometry of the pulsed gate beams.