A trace evidence material (TEM) collection device is disclosed that enables crime scene investigators to quickly and easily collect, analyze, annotate, securely store and electronically distribute images of large amounts of trace evidence materials and related crime scene information while also helping to comply with required trace evidence recovery procedures and documentation requirements. The TEM collection device includes a reusable handle and cassette drive mechanism, which may be used with a plurality of single-use cassettes. Each cassette includes a TEM collection media (such as a collection tape or swabbing pads attached to a substrate) that when moved across a surface is capable of collecting TEMs located on the surface. Preferably, each cassette also includes a sealing assembly that seals the TEM collection media after collection of the TEMs so as to preserve the collected TEMs.

Systems and methods for selecting therapeutic agents for cancers using next generation sequencing, automated dissection, and/or automated slide stainers are disclosed. Non-responsive regions of a tumor sample having a heterogenous staining pattern for a predictive biomarker are excised using an automated dissection tool. Mutations linked to additional predictive biomarkers are identified in the excised portion of the sample by next generation sequencing. The relevance of the additional predictive biomarker(s) is confirmed by histochemical staining. Therapeutic courses may then be selected on the basis of the staining patterns of the predictive biomarkers.

A method for counting blood cells in a sample of whole blood. The method comprises the steps of: (a) providing a sample of whole blood; (b) depositing the sample of whole blood onto a slide, e.g., a microscope slide; (c) employing a spreader to create a blood smear; (d) allowing the blood smear to dry on the slide; (e) measuring absorption or reflectance of light attributable to the hemoglobin in the red blood cells in the blood smear on the slide; (f) recording a magnified two-dimensional digital image of the area of analysis identified by the measurement in step (e) as being of suitable thickness for analysis; and (g) collecting, analyzing, and storing data from the magnified two-dimensional digital image.
Optionally, steps of fixing and staining of blood cells on the slide can be employed in the method.

A device for cutting off one or more sample regions from a sample carrier that contains impregnated sample material, e.g. blood, is described. The device includes: a cutting unit (103) for cutting off the one or more sample regions from the sample carrier, an optical imaging unit (101) for producing an electronic image of the sample carrier, and a processor (102) for controlling a display screen (108) to display the image (104) and one or more indicators (105, 105) each expressing the location of one sample region to be cut off. Thus, an operator of the device is enabled to monitor, without direct visual communication to the sample carrier, what region or regions of the sample carrier is/are to be cut off. As no direct visual communication with the sample carrier is needed, the working ergonomics of the operator can be improved.

Provided is a method for selectively analyzing biological samples. The method includes: preparing a substrate on which biological samples are arranged; dividing the substrate into areas where one or more target specimens are located and areas where one or more non-target specimens are located; forming a masking structure to selectively mask the areas where the non-target specimens are located; introducing a biochemical reaction reagent into the areas where the target specimens are located, such that the biochemical reaction reagent reacts with the target specimens; and analyzing the reacted target specimens on the substrate or recovering the reacted target specimens from the substrate and analyzing the recovered target specimens.

Areas having different isotopic ratios are artificially introduced into a metal material before sintering, a heat treatment, or grain boundary diffusion, and atom probe analysis results before and after sintering, a heat treatment, or grain boundary diffusion are compared to evaluate a change in isotopic distribution over time.

An autonomous soil sampling device. The device including a vehicle for generally autonomously navigating a given area for sampling and adapted with systems to generally avoid obstacles during maneuvering. The device including a soil sampling system designed for placement on a platform of the vehicle and including an extraction arm having a probe and auger to probe into the soil for extracting a quantity of soil. The extraction arm rotationally received on a housing and movable to an inverted position for depositing the quantity of extracted soil into a packaging assembly for collection, labeling, and storage of the individual samples.

The present disclosure provides methods for automated slide assessments made in conjunction with digital image-based microscopy. Automated methods of acquiring patient information and specimen information from prepared slides, and digitally linking such information into patient-tagged specimen data, are provided. Also provided are methods that include automatically identifying an optimal area for morphological assessment of a blood smear on a hematological slide, including methods for triggering the analysis of such an area, e.g., using an automated digital image-based hematology system. The present disclosure also provides devices, systems and computer readable media for use in performing processes of the herein described methods.

A method for examining and processing a microscopic sample arranged on a slide includes producing reference markings on the slide by a laser beam of a laser microdissection system. A digital image of the sample and the reference markings on the slide is produced by a digital optical imaging device. An image region is defined and first position information data which indicate a position of the image region is generated. The reference markings are identified in the image and second position information data which indicate a position of the reference markings in the image is generated. The reference markings are identified, and third position information data which indicate the position of the reference markings in the laser microdissection system is generated. The first, second and third position information data are correlated and a sample region which corresponds to the image region is processed.

A method for counting blood cells in a sample of whole blood. The method comprises the steps of: (a) providing a sample of whole blood; (b) depositing the sample of whole blood onto a slide, e.g., a microscope slide; (c) employing a spreader to create a blood smear; (d) allowing the blood smear to dry on the slide; (e) measuring absorption or reflectance of light attributable to the hemoglobin in the red blood cells in the blood smear on the slide; (f) recording a magnified two-dimensional digital image of the area of analysis identified by the measurement in step (e) as being of suitable thickness for analysis; and (g) collecting, analyzing, and storing data from the magnified two-dimensional digital image. Optionally, steps of fixing and staining of blood cells on the slide can be employed in the method.