G01N2001/366

ENHANCED HYDRATION METHODS AND SYSTEMS FOR HISTOLOGY

There is provided a histology system that comprises a microtome configured to expose a face of a tissue block comprising a tissue sample embedded in an embedding material and remove one or more tissue sections from the sample, a hydration system configured to hydrate the tissue block by depositing a hydrating liquid on the face of the tissue block, and a transfer system configured to transfer the one or more tissue sections from the microtome to one or more slides. In some embodiments, the hydration system is configured to produce droplet condensation of the hydrating liquid and deposit the condensation on the face of the tissue block.

Sectionable cassette and embedding frame with tissue immobilizing separable lid, and methods for preparing biopsy tissue samples
11774330 · 2023-10-03 · ·

A histologic tissue sample support device includes a tissue cassette a frame, and a lid. The tissue cassette has a recess including a body with at least one side wall and a bottom wall and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The tissue cassette is movably coupled to the frame. The lid is separably coupled to a peripheral portion of the frame. When the lid is separated from the peripheral portion, the lid and the tissue cassette are capable of moving from a first position to a second position with respect to the frame, and in the second position the bottom wall and at least a portion of the side wall extend beyond a bottom edge of the frame for sectioning in the microtome.

Mold coating agent test device having frame positioning portion that positions frame portion of metal mold
11796435 · 2023-10-24 · ·

A mold coating agent test device includes a frame positioning portion and a connection positioning portion. The frame positioning portion positions a frame portion of a metal mold such that the frame portion of the metal mold is positioned at a predetermined position when the metal mold is placed on a metal block. The connection positioning portion positions a connecting portion such that the connecting portion that is a portion provided in the frame portion and to which a drive unit that applies a force is connected is positioned at a predetermined position when the metal mold is placed on the metal block.

Module for freezing and storage of frozen tissue

An article comprising: a planar base having a first surface and an opposing second surface and an outer peripheral edge, wherein the second surface includes an area comprising a plurality of protuberances and configured to attach and maintain orientation of a frozen tissue specimen block; and a removable lid having a first side and a second side, wherein the first side defines a continuous planar surface and the second side defines a recessed portion configured to cover a frozen tissue specimen block and an outer rim configured to engage with the outer peripheral edge of the base, wherein the outer rim does not form part of the recessed portion, wherein the area of the base and the recessed portion of the lid are aligned.

SECTIONABLE CASSETTE AND EMBEDDING FRAME WITH TISSUE IMMOBILIZING SEPARABLE LID, AND METHODS FOR PREPARING BIOPSY TISSUE SAMPLES
20230375444 · 2023-11-23 ·

A histologic tissue sample support device includes a tissue cassette a frame, and a lid. The tissue cassette has a recess including a body with at least one side wall and a bottom wall and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The tissue cassette is movably coupled to the frame. The lid and the tissue cassette are capable of moving from a first position to a second position with respect to the frame, and in the second position the bottom wall and at least a portion of the side wall extend beyond a bottom edge of the frame for sectioning in the microtome.

METHOD FOR NON-DESTRUCTIVE INSPECTION OF A STRUCTURE AND CORRESPONDING SYSTEM
20220214161 · 2022-07-07 · ·

The present disclosure relates to a method for non-destructive inspection of a structure, preferably a through-glass via, TGV, of a substrate, preferably a glass substrate, comprising the steps of: applying a moldable mass onto a surface of the structure of the substrate; hardening of the moldable mass so that the mass is elastic; non-destructive removing of the elastic mass from the structure; and analyzing the removed elastic mass according to at least one parameter, preferably a quality parameter.

MOLD COATING AGENT TEST DEVICE
20220291104 · 2022-09-15 · ·

A mold coating agent test device includes a frame positioning portion and a connection positioning portion. The frame positioning portion positions a frame portion of a metal mold such that the frame portion of the metal mold is positioned at a predetermined position when the metal mold is placed on a metal block. The connection positioning portion positions a connecting portion such that the connecting portion that is a portion provided in the frame portion and to which a drive unit that applies a force is connected is positioned at a predetermined position when the metal mold is placed on the metal block.

SECTIONABLE CASSETTE AND EMBEDDING FRAME WITH TISSUE IMMOBILIZING SEPARABLE LID, AND METHODS FOR PREPARING BIOPSY TISSUE SAMPLES
20220090996 · 2022-03-24 ·

A histologic tissue sample support device includes a tissue cassette a frame, and a lid. The tissue cassette has a recess including a body with at least one side wall and a bottom wall and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The tissue cassette is movably coupled to the frame. The lid is separably coupled to a peripheral portion of the frame. When the lid is separated from the peripheral portion, the lid and the tissue cassette are capable of moving from a first position to a second position with respect to the frame, and in the second position the bottom wall and at least a portion of the side wall extend beyond a bottom edge of the frame for sectioning in the microtome.

DEVICE, SYSTEM, AND METHOD FOR RAPID FIXATION AND EMBEDDING OF BIOLOGICAL SPECIMENS
20220074828 · 2022-03-10 · ·

Provided herein is a device for rapid fixation and embedding of a biological specimen, the device including a barrel having a first end and a second end, the first end receiving a plunger and the second end opening to a compartment defining a block mold; and a plunger for inserting in the barrel, the plunger having a first end, a second end, and an interior conduit connecting the first and second ends, wherein the first end of the plunger connects to a vacuum source and the second end of the plunger includes a filter barrier between the interior conduit of the plunger and a receptacle for receiving, fixing, and embedding the specimen, the receptacle defined inside the barrel when the plunger is disposed in the barrel. Also provided are a system and method for rapid fixation and embedding of a biological specimen.

Tissue cassette/block file position flag and method related thereto
11266382 · 2022-03-08 ·

A flag, or marker for identifying the locations of a plurality of tissue cassettes containing mounted Formalin Fixed Paraffin Embedded (FFPE) tissue specimens once removed from a tissue cassette/block storage system. The invention comprises a rectangular cuboid body member having front, rear, left, right, top, and bottom surfaces which substantially approximates the shape of a predefined number of tissue cassette/blocks, with a recessed area with grooves to accept one tissue index marker card for recording the patient's case information, or other relevant information. When multiples of the present invention are used within a tissue cassette/block storage system, they point to locations where pluralities of tissue cassette/blocks should be returned, and provides a support structure for neighboring tissue cassette/blocks within the storage location from becoming askew or damaged within the tissue cassette/block storage system.