Patent classifications
G01N2001/386
SYSTEM AND METHOD FOR SAMPLE PREPARATION IN GMR-BASED DETECTION OF BIOMARKERS
A cartridge assembly, and method of using the same, is provided. The assembly includes a sample processing card and a substrate attached thereto. The card has an injection port for receiving a test sample; at least one metering chamber; a mixing material source for introducing mixing material(s) to the metering chamber; fluid communication channels fluidly connecting the injection port and the mixing material source to the metering chamber; and at least one output port for delivering the test sample to a sensor (e.g., GMR sensor). The substrate has associated therewith: the sensor for sensing analytes in the test sample; electrical contact portions for an electrical connection with a reader unit; and a memory chip. The assembly further includes a pneumatic interface with port(s) and corresponding communication channel(s) fluidly connected to card. The interface connects with an off-board pneumatic system and enables application of positive and negative pressurized fluid to the card to move the test sample and one or more mixing materials therein and to the sensor.
ELECTROSTATIC LOADING OF POWDER SAMPLES FOR IONIZATION
Methods and devices for pretreatment of a conducting sampling substrate which enable an electrostatic charge to be used to transfer analyte molecules onto a sampling substrate, where the analyte molecules are in powder or particulate form. In an embodiment of the present invention, the electrostatic charge can be used to transfer powder samples containing nitrogenous bases, nucleosides, food additives, and prescription drugs such as acetaminophen, oxycodone, and dextromethorphan. In an embodiment of the present invention, a powder sample is transferred to a pre-treated sampling substrate using an electrostatic charge. The spatial distribution of the powder on the original surface is retained on the pre-treated sampling substrate using the electrostatic charge transfer. The electrostatic charge transfer can be used to transfer powder samples present on a surface or in the chambers of 96, 384 and 1536 well plate formats to either pins or mesh and analyzed with ambient desorption ionization.
High temperature high pressure (HTHP) cell in sum frequency generation (SFG) spectroscopy for oil/brine interface analysis with reservoir conditions and dynamic compositions
A pressure cell for sum frequency generation spectroscopy includes: a metal pressure chamber; a heating stage that heats a liquid sample; an ultrasonic stage that emulsifies the liquid sample; a chamber pump that pressurizes an interior of the metal pressure chamber; and a controller that controls the chamber pump, the ultrasonic stage, and the heating stage to control a pressure of the interior of the metal pressure chamber, an emulsification of the liquid sample, and a temperature of the liquid sample, respectively. The metal pressure chamber includes: a liquid sample holder that retains the liquid sample; a removable lid that seals against a base; a window in the removable lid; a sample inlet that flows the liquid sample from an exterior of the metal pressure chamber to the liquid sample holder at a predetermined flow rate; and a sample outlet.
MICROFLUIDIC DISPENSERS FOR LIMITING DILUTION
A microfluidic dispenser can include a processor to receive a user input via a user interface related to limiting dilution (or a limiting dilution assay) to be performed, and calculate a dispense volume of a fluid for the limiting dilution based on the user input. The microfluidic dispenser can also include a dispense cassette including a fluid reservoir, and a microfluidic dispense head to dispense the fluid via a nozzle in accordance with the calculated dispense volume.
Quantitative analysis method for high molecular weight antioxidant
A method for analyzing an antioxidant content contained in a semiconductive material for a cable, which includes an amine-based antioxidant. The method can provide an accurate quantitative analysis value obtained by a comparison with the actual amount used, through gas chromatography (GC)/a flame ionization detector (FID).
IMMUNOASSAY METHOD AND DETECTION KIT FOR RESPIRATORY TRACT VIRUS
The invention aims to carry out an immunoassay method for a respiratory tract virus, wherein non-specific reaction is suppressed. The object can be achieved by an immunoassay method for a respiratory tract virus, the method comprising: (A) bringing a biological sample that may contain a respiratory tract virus into contact with an anionic surfactant; (B) bringing the respiratory tract virus into contact with a conjugate, to forma first complex; (C) bringing the first complex into contact with an antibody immunologically reactive with the respiratory tract virus, to forma second complex; and (D) measuring a signal derived from the conjugate.
Solvent compound for a particle counter/imager and associated method
A solvent compound for a particle counter/imager system, the solvent compound includes a liquid solvent miscible with oil to remove oil from the particle counter/imager system and a liquid dispersive surfactant configured to break large water droplets into smaller droplets less than a predetermined size. The liquid dispersive surfactant is miscible with the solvent and is nontoxic and nonflammable.
Stirring apparatus and stirring system
The present invention relates to an apparatus (100) for producing a driving force for stirring samples, in particular samples for laboratory operations such as, for example, liquids, liquids with solid samples contained therein or solid samples, said apparatus comprising a sample holder (200) for receiving at least one sample vessel (220) for samples and a bar element (300), which extends along a longitudinal axis (LA) and which is connected to the sample holder (200), wherein the bar element (300) comprises a coupling portion (310) for detachably coupling the bar element (300) to an operating unit (800), a fastening portion (320) for fastening the sample holder (200) to the bar element (300) and for positioning the sample holder (200) along the longitudinal axis (LA) in defined fashion, and a magnetic stirring portion (330), wherein the bar element (300) is embodied in such a way that a magnetic field that rotates relative to the sample holder (200) about the longitudinal axis (LA) can be produced by means of the magnetic stirring portion (330). The invention further relates to system (700) comprising an operating unit (800) and the apparatus (100) according to the invention, which are detachably coupled by way of the coupling portion (310). The invention further relates to a process for stirring samples in sample vessels by means of the system (700).
Biological fluid collection device and collection module
A biological fluid collection device that receives a sample and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed. A biological fluid collection device of the present disclosure is able to effectuate distributed mixing of a sample stabilizer within a blood sample and dispense the stabilized sample in a controlled manner. In this manner, a biological fluid collection device of the present disclosure enables blood micro-sample management, e.g., passive mixing with a sample stabilizer and controlled dispensing, for point-of-care and near patient testing applications.
APPARATUSES AND METHODS FOR MIXING FLUID OR MEDIA BY VIBRATING A PIPETTE USING TRANSIENT AND STEADY-STATE INTERVALS
In an embodiment, an immunochemistry analysing system includes a source of paramagnetic particles, a source of fluid, a cuvette configured to receive the paramagnetic particles and the fluid, a pipette configured to (i) translate so that at least a portion of the pipette is located within the cuvette and (ii) dispense at least one of the paramagnetic particles and the fluid into the cuvette so that the paramagnetic particles and the fluid can be mixed within the cuvette, a motor configured to move the pipette while located in the cuvette, and a control unit configured to vary a motor drive of the motor to cause the pipette to mix the fluid with the paramagnetic particles within the cuvette.