A water purification system is disclosed which, includes a reverse osmosis (RO) system or component that is connectable to a city or other outside water feed that is capable of responding to and compensating for low or no feed water pressure coming into the RO system to ensure the outgoing supply of purified water is provided consistently and at a minimum water pressure. This can be accomplished without the need for communication with another device or system-wide facility, such as a hospital, or a pharmaceutical or semiconductor manufacturing system, requiring a constant water supply.

Apparatus comprising an inlet region for receiving a gas mixture; an ionizer for supplying hydronium ions to the received gas mixture to generate ions, wherein the ionizer comprises a membrane for receiving the gas mixture, and wherein the membrane, preferably made of graphene oxide, is capable of generating hydronium ions from water; and an ion detector for detecting ions generated from the gas mixture.

There is provided a system for performing a chromatographic separation of an analyte, methods of using the system to separate at least one component of an analyte and an eluent generator of use in the system. An exemplary system comprises: (a) an eluent generator comprising: (i) a housing configured to be pressurizable by gas, comprising an annular void defined by the housing, and a gas inlet for the gas and a gas outlet for the gas in fluid communication with the annular void; (ii) a membrane permeable to the gas defining an eluent flow channel disposed within the annular void, the eluent flow channel having an eluent precursor fluid inlet and an eluent outlet; (iii) a source of gas in fluidic communication with the gas inlet; (iv) a source of the eluent precursor fluid; and (b) a chromatography column disposed downstream of and in fluidic communication with the eluent outlet.

An optical spectroscopy probe including an optical fiber having a distal tip and a microfluidic filtering chamber attached to the distal tip of the optical fiber, the chamber comprising a microfluidic membrane configured to enable liquid to enter the chamber but prevent particles from entering the chamber. Method for fabrication of same.

A method for pre-analytical treatment of a serum or plasma sample from a patient suspected of suffering from oxidative stress, which includes contacting the sample with one or more microcapsules having a gelled alginate core and a semipermeable coating, where the alginate core includes dispersed receptors against an oxidised human parathyroid hormone (PTH) peptide. The semipermeable membrane can be obtained by layer-by-layer deposition of polycationic and polyanionic macromolecules onto the gelled core, following by hardening, crosslinking and co-acervation of the macroionic phases.

A device including an ion-selective membrane arranged within an optical path of the device and coupled to a sample cell to interact with a fluid sample and thereby modify an optical response of the ion-selective membrane according to an ion con-centration in the fluid sample, is provided. The device also includes an integrated computational element (ICE) arranged within the optical path, so that the illumination light optically interacts with the ICE and with the ion-selective membrane to provide a modified light that has a property indicative of the ion concentration in the fluid sample. A detector that receives the modified light provides an electrical signal proportional to the property of the modified light. A method and a system for using the above device are also provided.

There is provided a biological specimen separation instrument with which a biological specimen can be stably separated into a predetermined component. The biological specimen separation instrument includes an accommodation instrument (1) that accommodates a collected biological specimen, a filter (128) for filtering a predetermined component in the biological specimen, and a holding instrument (100) that accommodates the filtered predetermined component, where the holding instrument is configured to be inserted into the accommodation instrument (1), a sealing member (130) is provided in an outer circumference of the holding instrument (100) on the tip side in the direction of insertion to to be movable in the accommodation instrument (1), in a state of being in liquid-tight contact with an interior wall of the accommodation instrument (1), the filter (128) is held to the holding instrument (100) by a holder (140) forming a biological specimen inflow port (142) to the filter (128), and in a case where the filter (128) and the holding instrument (100) are cross-sectionally viewed, the sealing member (128) is positioned on a side opposite to the direction of insertion from an imaginary line (148) from an end part of the filter (128), where the imaginary line (148) is in contact with a tip side end part (146A) on an opposite side across a center of the filter (128).

The invention relates to a method for preparation of a sample (10) of a formulation (11) for subsequent endotoxin determination, the formulation (11) suspected of comprising an endotoxin, the formulation (11) preferentially being a pharmaceutical formulation. The method comprises the following steps: application of the sample (10) to an endotoxin-free centrifugation column (2) containing a size exclusion chromatography matrix (5) that has been equilibrated with a suitable equilibration buffer (6) and elution of a flow through (15) of the sample by centrifugation, which flow through (15) can then be used for endotoxin determination. The equilibration buffer (6) is selected according to a subsequently used method of endotoxin determination, the equilibration buffer (6) only containing components not interfering with subsequently used method of endotoxin determination. Furthermore, the invention relates to a kit (20) for preparation of a sample (10).

Provided are methods, devices, and kits for the isolation of extracellular vesicles using silicon nanomembranes. A method for EV isolation includes the steps of collecting a biofluid sample, contacting the biofluid sample with a pre-filtration membrane, thereby forming a first filtrate and a first retentate, optionally, washing the first retentate of the pre-filtration membrane, contacting the first filtrate from the pre-filtration membrane with a capture membrane, thereby forming a second filtrate and a second retentate, optionally, washing the second retentate, and eluting the second retentate from the capture membrane or lysing the second retentate to recover the contents.

A medical apparatus is provided including an elongated body and defining a loading chamber between a proximal end and a distal end thereof for storing a liquid therein, the elongated body defining an outlet at the distal end thereof; a cell block filter assembly including a cell block body and defining a well portion matingly engageable with the distal end of the elongated body for receiving fluid from the outlet of the elongated body and defining a well opening on a bottom thereof; a filter membrane disposed across the well opening on the bottom of the well portion; and a cover member positionable over the well portion wherein the entire cell block filter assembly is sliceable into slices having a thickness suitable for mounting on a laboratory slide.