A device and method for separation of components of a sample, in particular for pressure separation of immiscible or liquid systems with limited miscibility having at least one first chamber with a U- or V-shaped bottom wherein at least one aperture with a diameter within the range of 1 to 100 μm, preferably 1 to 40 μm, is provided in the first chamber and at least the surface of each aperture is hydrophilized or hydrophobized is disclosed. The device further has a second chamber surrounding the outside of the bottom of the first chamber. The invention also provides a method for separating components of a sample using this device and additionally enables parallel arrangement for plurality of separating conditions and serial arrangement for plurality of separated samples at the same time.

Disclosed is a method for concentrating extracellular vesicles, comprising preparing a mixture comprising a first fraction and a second fraction by mixing a liquid sample comprising extracellular vesicles, a polysaccharide, and a polyether having an average molecular weight of 20,000 or less, wherein the first fraction comprises a higher concentration of extracellular vesicles than the second fraction, and the first fraction comprises a higher concentration of extracellular vesicles than the liquid sample.

Disclosed is a leaching solution composition for extracting available phosphate in soil, the composition including 100 parts by weight of a leaching solution containing acetic acid, lactic acid, ammonium fluoride, ammonium sulfate, and sodium hydroxide, of which the weights are 110% of the weights of constituent ingredients of a leaching solution for extracting available phosphate in soil, used in the Lancaster method and 0.001 parts by weight of a bromocresol green indicator.

A system for generating a concentrated product from a feedstock includes a feedstock chamber to which the feedstock is provided, a heat exchanger assembly in thermal communication with the feedstock chamber, the heat exchanger assembly being configured to freeze the feedstock in the feedstock chamber, an output flow arrangement configured to carry liquid from the feedstock chamber as the feedstock thaws, the output flow arrangement comprising a flow controller, a sensor disposed along the output flow arrangement or the heat exchanger assembly, the sensor being configured to measure a characteristic of the liquid, the characteristic being indicative of a solute concentration level of the liquid or the heat exchanger assembly, and a processor responsive to the characteristic and configured to control the flow controller to, based on the solute concentration level, direct the liquid passing through the output flow arrangement to define a plurality of products at different concentration levels, the plurality of products comprising the concentrated product.

Methods and devices for liquid-liquid extraction using digital microfluidic arrays are provided. A polar droplet is transported to a separation region containing a substantially non-polar solvent, where non-polar impurities may be extracted from the polar droplet while maintaining a distinct phase separation. In a preferred embodiment, biological samples containing hormones are dried on a digital microfluidic array, lysed by a lysing solvent, dried, subsequently dissolved in a polar solvent, and further purified in a separation step in which droplets are transported through a volume of non-polar solvent. The method disclosed herein provides the distinct advantage of an automated sample preparation method that is capable of extracting hormones from low sample volumes with high precision and recovery.

The present invention utilizes a high throughput testing (HTT) method of high performance liquid chromatography (HPLC) to validate samples of pharmaceutical compositions. In one embodiment, improved sample preparation techniques comprise adding the entire vial of a sample to a wide mouth disposable bottle, adding diluent, shaking overnight, and centrifuging.

An improved device for collecting particulate matter suspended in the ambient air is disclosed comprising a container extending between an open first end and a closed second end defining a container interior. A container output communicates with a container interior located proximate the closed second end of the container. A filter cassette comprising a collection filter is permanently affixed to a filter holder. A retainer having a retainer input retains the filter cassette between the retainer input and the container output. An output connector connects the container output to a low pressure source for drawing ambient air into the retainer input for enabling the collection filter to collect particulate matter suspended in the ambient air entering the retainer input. Preferably, the filter holder and the filter are disposable.

A method for quantifying acetylamantadine in a urine sample comprises eluting acetylamantadine from the urine sample using solid phase extraction and quantifying the acetylamantadine eluted from the urine sample using Raman spectroscopy.

The present invention relates to a method for determining the migration potential of an at least partially cured energy curing ink and/or varnish printed on a substrate comprising: —providing a substrate, which is printed with the ink and/or varnish, which comprises at least one extractable compound, which absorbs or emits radiation at at least one wavelength between 190 and 3,000 nm, —cutting at least one sample from the printed substrate, placing and incubating the sample in a solvent, in which the extractable compound is soluble, and removing the sample from the solvent to obtain a solvent extract, —quantitatively measuring a spectroscopic characteristic of the solvent extract at at least one wavelength between 190 and 3,000 nm, at which the extractable compound absorbs or emits radiation, so as to obtain a measured numeric value of the spectroscopic characteristic, and —comparing the measured numeric value of the spectroscopic characteristic with a calibration curve.

A system is provided for detecting the mass of oil in an inorganic mineral of shale. The system operates by performing an extraction test on a first shale sample by using chloroform to obtain a total content of shale oil in the shale; enriching kerogen from the second shale sample to obtain dry kerogen; and performing an extraction test on oven-dried kerogen by using chloroform to determine the mass of extracted kerogen. The system also operates by determining the mass of the oil in the organic matter of the shale sample and the mass of the oil in an inorganic mineral of the shale; establishing a model for predicting a ratio of the mass of the oil in the inorganic mineral of the shale to the mass of the oil in the organic matter; and using the prediction model to determine the mass of oil in an inorganic mineral.