Patent classifications
G
PHYSICS
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G01
MEASURING; TESTING
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G01N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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9/00
Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity
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G01N9/10
by observing bodies wholly or partially immersed in fluid materials
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G01N9/12
by observing the depth of immersion of the bodies, e.g. hydrometers
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G01N9/14
the body being built into a container
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G01N9/14

Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same
09632089 · 2017-04-25 · ·

The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of the compounds to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal degradation of a transmembrane or intracellular protein. The present invention further includes a method of identifying or validating a protein of interest as a therapeutic target for treatment of a disease state or condition.