The present invention relates to a device for measuring rheological properties of a high-viscosity material and a measurement method thereof in which, while a discharger of the present invention is completely blocked, a change in pressure of the high-viscosity material due to a change in the number of rotations of a first screw is measured, thus having an advantage of being able to precisely and reproducibly measure the viscosity.

A viscometer includes a viscosity sensor with a liquid flow channel and at least two pressure sensors positioned along the liquid flow channel and configured to measure a pressure drop of a liquid flowing through the liquid flow channel, and a dispensing mechanism configured to cause dispensing of a liquid from the syringe to the viscosity sensor at a known flow rate. The dispensing mechanism and the viscosity sensor are configured to couple with a syringe configured to contain a liquid. The viscometer further includes an electronic controller configured to control operations of the dispensing mechanism and receive and process data from the viscosity sensor. The viscometer includes a sample loading interface, included in the syringe, through which the viscometer is configured to receive the liquid. The sample loading interface includes a selection valve coupled with, and located between, the viscosity sensor and the syringe.

A viscometer includes a viscosity sensor with a liquid flow channel and at least two pressure sensors positioned along the liquid flow channel and configured to measure a pressure drop of a liquid flowing through the liquid flow channel, and a dispensing mechanism configured to cause dispensing of a liquid from the syringe to the viscosity sensor at a known flow rate. The dispensing mechanism and the viscosity sensor are configured to couple with a syringe configured to contain a liquid. The viscometer further includes an electronic controller configured to control operations of the dispensing mechanism and receive and process data from the viscosity sensor. The viscometer includes a sample loading interface, included in the syringe, through which the viscometer is configured to receive the liquid. The sample loading interface includes a selection valve coupled with, and located between, the viscosity sensor and the syringe.

The present disclosure describes a computer implemented method, a system, and a computer program product of determining intrinsic viscosity and Huggins constant of an unknown sample. In an embodiment, the method, system, and computer program product include, receiving specific viscosity values over time from a viscometer corresponding to a series of aliquots of an unknown sample injected into an instrument chain where the instrument chain includes the viscometer, calculating a total mass of each of the aliquots, calculating a first intermediate viscosity value of each of the aliquots, calculating a second intermediate viscosity value of each of the aliquots, and fitting the total mass, the first intermediate viscosity value, and the second intermediate viscosity value to a fitting, resulting in a calculated intrinsic viscosity of the unknown sample and a calculated Huggins constant of the unknown sample.

The present disclosure describes a computer implemented method, a system, and a computer program product of determining intrinsic viscosity and Huggins constant of an unknown sample. In an embodiment, the method, system, and computer program product include, receiving specific viscosity values over time from a viscometer corresponding to a series of aliquots of an unknown sample injected into an instrument chain where the instrument chain includes the viscometer, calculating a total mass of each of the aliquots, calculating a first intermediate viscosity value of each of the aliquots, calculating a second intermediate viscosity value of each of the aliquots, and fitting the total mass, the first intermediate viscosity value, and the second intermediate viscosity value to a fitting, resulting in a calculated intrinsic viscosity of the unknown sample and a calculated Huggins constant of the unknown sample.

This invention relates in general to the field of cell-therapy treatments and more particularly, but not by way of limitation, to systems and methods for validating personalized cell-therapy treatments. In various embodiments, the system may calculate an aspiration volume needed for centrifugation to achieve a concentrated target threshold dose for a particular cell therapy using various factors such as, for example, information about a patient and the efficiency of the concentration process. In various embodiments, the system may also provide an indication to a physician of relevant published cell therapies to assist the physician in administering a treatment protocol.

This invention relates in general to the field of cell-therapy treatments and more particularly, but not by way of limitation, to systems and methods for validating personalized cell-therapy treatments. In various embodiments, the system may calculate an aspiration volume needed for centrifugation to achieve a concentrated target threshold dose for a particular cell therapy using various factors such as, for example, information about a patient and the efficiency of the concentration process. In various embodiments, the system may also provide an indication to a physician of relevant published cell therapies to assist the physician in administering a treatment protocol.

A system includes a pump to circulate a flow of a fluid from a fluid source through a flow conduit assembly at unique flow rates; a flow meter fluidly coupled within the flow conduit assembly; a coiled tubing assembly fluidly coupled within the flow conduit assembly and including one or more tubing coils; a pressure sensor coupled to the flow conduit assembly and configured to measure a fluid pressure drop across the coiled tubing assembly; and a control system communicably coupled to the flow meter and the pressure sensor. The control system is configured to identify each of the unique flow rates of the flow of fluid through the coiled tubing assembly; identify, for each unique flow rate, the fluid pressure drop across the coiled tubing assembly; for each unique flow rate and corresponding measured fluid pressure drop, determine flow rate-dependent properties of the fluid; and generate a rheogram from the determined flow rate-dependent properties.

A measuring arrangement (1) for measuring the density of flowable media comprises: a fluid path (16) for conveying a medium; a pump (14), which is arranged in the fluid path (16), for driving a defined volume flow of the medium in the fluid path (16); a pressure difference measuring arrangement (30a, 30b) for registering a pressure drop due to the volume flow of the medium between a first pressure tap (32a) and a second pressure tap (32b) in the fluid path (16); a densimeter (20) comprising at least one oscillator, which has at least one oscillatable measuring tube (22) for conveying the medium, at least one exciter mechanism for exciting oscillations of the measuring tube, and at least one sensor arrangement for registering at least one oscillatory characteristic of the oscillator, wherein the measuring tube or the measuring tubes of the at least one oscillator are/is arranged in the fluid path; an evaluation apparatus (40), which is adapted to ascertain the density of the medium based on the volume flow, the volume flow dependent pressure drop and the at least one oscillatory characteristic of the oscillator.

A measuring arrangement (1) for measuring the density of flowable media comprises: a fluid path (16) for conveying a medium; a pump (14), which is arranged in the fluid path (16), for driving a defined volume flow of the medium in the fluid path (16); a pressure difference measuring arrangement (30a, 30b) for registering a pressure drop due to the volume flow of the medium between a first pressure tap (32a) and a second pressure tap (32b) in the fluid path (16); a densimeter (20) comprising at least one oscillator, which has at least one oscillatable measuring tube (22) for conveying the medium, at least one exciter mechanism for exciting oscillations of the measuring tube, and at least one sensor arrangement for registering at least one oscillatory characteristic of the oscillator, wherein the measuring tube or the measuring tubes of the at least one oscillator are/is arranged in the fluid path; an evaluation apparatus (40), which is adapted to ascertain the density of the medium based on the volume flow, the volume flow dependent pressure drop and the at least one oscillatory characteristic of the oscillator.